Preservation of the anterior fat pad paradoxically decreases the incidence of postoperative atrial fibrillation in humans

Abstract

This is the first study demonstrating that direct stimulation of the human anterior epicardial FP slows sinus CL. This parasympathetic effect is eliminated with FP dissection. Preservation of the human anterior epicardial FP during CABG decreases incidence of postoperative AF.

Efeito da denervação cardíaca ventral na incidência de fibrilação atrial após revascularização cirúrgica do miocárdio

“…In contrast to this study, Cummings et al [17] evaluated the influence of the nerves of the parasympathic nervous system present in the tissue removed during ventral cardiac denervation. A total of 55 patients were submitted to CABG after being randomized for denervation or not.…”

The influence of preoperative pharmacotherapy on the appearance of postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting

“…18,19,20 Indeed, removal of parasympathetically innervated aortic fat has been demonstrated to increase the risk of developing AF. 21 Similarly, smoking interferes with the hyperadrenergic state registered after surgical trauma. Smokers have a higher adrenergic tolerance and are protected against POAF.…”

Current Trend of Off-Pump Coronary Artery Bypass Grafting

“…The incidence of atrial fibrillation after OPCAB is known to be less than that for on-pump CABG , Raga et al, 2004. Avoiding atrial cannulation and preserving the anterior epiaortic fat pad may contribute to lowering the incidence of postoperative atrial fibrillation (Cummings et al, 2004).…”