Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes

Machado, Noelia D.; Gutiérrez, Gemma; Matos, María; Fernández, María Aurora

doi:10.3390/foods10050988

Cited by 22 publications

(12 citation statements)

References 51 publications

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“…Applications of niosomes can be found in both cosmetic and pharmaceutical industries, taking advantage of their property of enhancing the bioavailability of bioactive compounds [ 134 ]. They are usually applied for the protection of sensitive compounds such as vitamin A and Ε or resveratrol [ 134 , 135 , 136 ]. Interestingly, niosomes provide a protective delivery system for antibiotics, making them remarkably effective in orthopedic, orthodontic, ophthalmological, and other treatments [ 137 ].…”

Section: Applications Of Nanotechnology In the Cosmetics And Food Ind...mentioning

confidence: 99%

Applications and Prospects of Nanotechnology in Food and Cosmetics Preservation

2022

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Cosmetic and food products containing water are prone to contamination during the production, storage, and transit process, leading to product spoilage and degraded organoleptic characteristics. The efficient preservation of food and cosmetics is one of the most important issues the industry is facing today. The use of nanotechnology in food and cosmetics for preservation purposes offers the possibility to boost the activity of antimicrobial agents and/or promote their safer distribution into the end product upon incorporation into packaging or film constructions. In this review, current preservation strategies are discussed and the most recent studies in nanostructures used for preservation purposes are categorized and analyzed in a way that hopefully provides the most promising strategies for both the improvement of product safety and shelf-life extension. Packaging materials are also included since the container plays a major role in the preservation of such products. It is conclusively revealed that most of the applications refer to the nanocomposites as part of the packaging, mainly due to the various possibilities that nanoscience offers to this field. Apart from that, the route of exposure being either skin or the gastrointestinal system involves safety concerns, and since migration of nanoparticles (NPs) from their container can be measured, concerns can be minimized. Conclusion: Nanomaterial science has already made a significant contribution to food and cosmetics preservation, and rapid developments in the last years reinforce the belief that in the future much of the preservation strategies to be pursued by the two industries will be based on NPs and their nanocomposites.

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Section: Applications Of Nanotechnology In the Cosmetics And Food Ind...mentioning

confidence: 99%

Applications and Prospects of Nanotechnology in Food and Cosmetics Preservation

2022

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“…However, there is controversy regarding resveratrol’s effects on disease and its side effects [ 50 ]. These studies lay the foundation for applying resveratrol in preventing ischemic stroke and OGD cell models [ 44 , 51 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture

Chiang

Nicol

et al. 2022

IJMS

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Oxygen glucose deprivation (OGD) can produce hypoxia-induced neurotoxicity and is a mature in vitro model of hypoxic cell damage. Activated AMP-activated protein kinase (AMPK) regulates a downstream pathway that substantially increases bioenergy production, which may be a key player in physiological energy and has also been shown to play a role in regulating neuroprotective processes. Resveratrol is an effective activator of AMPK, indicating that it may have therapeutic potential as a neuroprotective agent. However, the mechanism by which resveratrol achieves these beneficial effects in SH-SY5Y cells exposed to OGD-induced inflammation and oxidative stress in a 3D gelatin scaffold remains unclear. Therefore, in the present study, we investigated the effect of resveratrol in 3D gelatin scaffold cells to understand its neuroprotective effects on NF-κB signaling, NLRP3 inflammasome, and oxidative stress under OGD conditions. Here, we show that resveratrol improves the expression levels of cell viability, inflammatory cytokines (TNF-α, IL-1β, and IL-18), NF-κB signaling, and NLRP3 inflammasome, that OGD increases. In addition, resveratrol rescued oxidative stress, nuclear factor-erythroid 2 related factor 2 (Nrf2), and Nrf2 downstream antioxidant target genes (e.g., SOD, Gpx GSH, catalase, and HO-1). Treatment with resveratrol can significantly normalize OGD-induced changes in SH-SY5Y cell inflammation, oxidative stress, and oxidative defense gene expression; however, these resveratrol protective effects are affected by AMPK antagonists (Compounds C) blocking. These findings improve our understanding of the mechanism of the AMPK-dependent protective effect of resveratrol under 3D OGD-induced inflammation and oxidative stress-mediated cerebral ischemic stroke conditions.

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“…It can reduce insulin sensitivity, combat atherosclerosis, and prevent or treat cancer. [20][21][22][23][24][25] Bielas et al 6 synthesized hybrid sugar/poly(2-dimethylamino ethyl methacrylate) star copolymers with a resveratrol-like core. They showed their cytotoxicity against various cancer cells.…”

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confidence: 99%

Hydroxypropyl methacrylate stars as versatile carriers of therapeutic agents

Sentoukas,

Forys,

Otulakowski

et al. 2024

J of Applied Polymer Sci

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Three star‐like carriers with poly(hydroxy propyl methacrylate) (PHPMA) cores and poly(oligoethylene glycol methacrylate) (POEGMA) arms as nanocarriers were utilized for the encapsulation of rhodamine B, resveratrol, and curcumin. These drugs differ in hydrophobicity and therapeutic effects. The carriers had high encapsulation and loading efficiency (>95% and 10 wt%, respectively) and formed hydrogen bonds with the drugs. They were spherical in phosphate buffer saline and formed aggregates of various sizes (11–116 nm) depending on the star composition and the drug type. The carriers were stable for 2 months, but released different amounts of drugs afterwards, except for curcumin, which stayed entrapped. The curcumin‐loaded carriers also generated reactive oxygen species. These findings demonstrate the versatility of PHPMA/POEGMA stars as nanocarriers for diverse applications in nanomedicine.

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Preservation of the Antioxidant Capacity of Resveratrol via Encapsulation in Niosomes

Cited by 22 publications

References 51 publications

Applications and Prospects of Nanotechnology in Food and Cosmetics Preservation

Applications and Prospects of Nanotechnology in Food and Cosmetics Preservation

Resveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture

Hydroxypropyl methacrylate stars as versatile carriers of therapeutic agents

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