Preservation of Typhoid Vaccine

Henderson, DK; Peacock, Sharon J.; Richley, J.

doi:10.1016/s0140-6736(51)91121-x

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…The results so far described were obtained with strain Ty2 as the test culture. This strain had been selected for this study, since on the basis of laboratory criteria, acetone-killed suspensions of these cells have been demonstrated to be superior vaccines (Henderson et al, 1951, Landy, 1953. Nevertheless, heat-killed, phenol-preserved vaccines prepared from S. typhosa strain V58 are widely used for immunization.…”

Section: Descriptiono Enitrogenmentioning

confidence: 99%

THE VIRULENCE AND IMMUNOGENICITY OF SALMONELLA TYPHOSA GROWN IN CONTINUOUS CULTURE

1956

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Section: Descriptiono Enitrogenmentioning

confidence: 99%

THE VIRULENCE AND IMMUNOGENICITY OF SALMONELLA TYPHOSA GROWN IN CONTINUOUS CULTURE

1956

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“…cine may be expected to retain potency well beyond this limit. One vaccine was found potent after 15 years (3,4). No mention of pH control has been observed in reports of potency loss related to age and/or storage conditions (3,4,6,9,10).…”

Section: Resultsmentioning

confidence: 99%

Effect of Glass on pH-Dependent Stability of Typhoid Vaccine

Driesens

1975

J Clin Microbiol

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Vaccines made from the Ty-2 strain of Salmonella typhosa were tested periodically for stability of pH and of potency. The acetone-treated cultures prepared in buffered saline solutions retained potency beyond 30 months of storage at 0 to 5 C. Similar vaccines in unbuffered saline solutions lost potency coincident with increase of alkalinity. Vaccines packaged in United States Pharmacopeia borosilicate glass vials retained potency and pH stability, whereas those in Type III United States Pharmacopeia soda-lime glass vials were less stable.

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“…This vaccine, in a concentration of 2000 million organisms per ml. in 0-01 % merthiolate, was divided in two portions: while one portion was stored in a refrigerator at a temperature of 4-60 C., the other half was kept at a temperature of 410 C. for 12 months to study the effects of improper and unfavourable storage conditions on this vaccine (accelerated ageing, Landy, 1953;Henderson, Peacock & Rickley, 1951).…”

Section: In Vivo Experimentsmentioning

confidence: 99%

Chrome typhoid vaccine

Vella

1963

J. Hyg.

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1. Experimental typhoid vaccines, treated by 1% formalin and 0·02% chrome alum (KCr(SO4)2.12H2O), as suggested by Japanese workers were prepared and tested by the usual in vitro and in vivo tests.2. Agglutination tests, antibody production in rabbits, active and passive mouse protection tests confirm the stability of the Vi antigen of the vaccine, if properly stored, and the good protection afforded to laboratory animals in both the active and passive mouse protection tests.3. It is suggested that only a full-scale field trial in a typhoid endemic area can give the answer as to the real efficacy and/or superiority of the chrome vaccine over other typhoid vaccines.

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Preservation of Typhoid Vaccine

Cited by 4 publications

References 4 publications

THE VIRULENCE AND IMMUNOGENICITY OF SALMONELLA TYPHOSA GROWN IN CONTINUOUS CULTURE

THE VIRULENCE AND IMMUNOGENICITY OF SALMONELLA TYPHOSA GROWN IN CONTINUOUS CULTURE

Effect of Glass on pH-Dependent Stability of Typhoid Vaccine

Chrome typhoid vaccine

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