Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection

Higuchi, Naomi; Nakamura, Kazuhiko; Ihara, Eikichi; Akahoshi, Kazuya; Akiho, Hirotada; Sumida, Yorinobu; Motomura, Yasuaki; Kubokawa, Masaru; Ito, Tetsuhide; Takayanagi, Ryoichi

doi:10.1111/jgh.12086

Cited by 10 publications

(10 citation statements)

References 14 publications

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“…The types of solid tumors included were breast, lung, genitourinary, gynecologic, gastrointestinal, and head and neck cancer, but patients with nonmetastatic papillary thyroid cancer or endoscopically resected early gastric or colon cancer were excluded because patients with these tumors have a relatively high QOL compared to patients with other solid tumors due to minimal major organ dysfunction and a survival rate of nearly 100% with treatments. 34 Patients were recruited from outpatient clinics during their clinic visits for postoperative follow-up, cancer treatment (chemotherapy and/or radiotherapy), or postcancer treatment checkup. Of 233 patients approached, 216 (92.7%) consented to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Complementary and Alternative Medicine Use and Its Association with Emotional Status and Quality of Life in Patients with a Solid Tumor: A Cross-Sectional Study

Jang

Kang

Kim

2017

The Journal of Alternative and Complementary Medicine

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Objectives: Complementary and alternative medicine (CAM) has been used widely in various populations for various purposes, including emotional support and improvement of quality of life (QOL). However, CAM use and purposes for using CAM are less clear among Korean patients with a solid tumor. The purpose of this study was to determine the prevalence and type of CAM use, and the association between CAM use and anxiety, depression, and QOL in patients with a solid tumor.Design: A cross-sectional survey.Setting: A cancer center in Korea.Subjects: Two hundred and sixteen patients diagnosed with a solid tumor.Outcome measures: Standard questionnaires on CAM use, Hospital Anxiety and Depression Scale, and European Organization for Research and Treatment of Cancer QLQ-C30.Results: One hundred thirty one patients (60.6%) reported using CAM. CAM users, compared with non-CAM users, were significantly younger (57.8 vs. 60.9 years, p = 0.05), had higher level of education (p = 0.008), had higher income (p = 0.008), were less likely to seek physician consultation on CAM use (p = 0.002), and had a more advanced stage of tumor (p = 0.003) with more distant metastasis (p = 0.001). The most commonly used CAM was herbal medicine (n = 89, 67.9%). CAM users had significantly lower anxiety (t = 5.21, p < 0.001) and depression (t = 4.90, p < 0.001) than non-CAM users. When the effects of CAM use were tested on anxiety, depression, and QOL, controlling for covariates, CAM use was significantly associated with 8.7% and 8.8% of variance in decreasing anxiety and depression, but there was no unique association of CAM use with variance in QOL.Conclusions: CAM use is prevalent and younger age, higher education levels, higher income, less physician consultation, and higher cancer stage are significant correlates to CAM use. Controlling for covariates (e.g., gender, BMI), CAM use is significantly associated with lower anxiety and depression compared with those of non-CAM users.

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Section: Methodsmentioning

confidence: 99%

Complementary and Alternative Medicine Use and Its Association with Emotional Status and Quality of Life in Patients with a Solid Tumor: A Cross-Sectional Study

Jang

Kang

Kim

2017

The Journal of Alternative and Complementary Medicine

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“…This finding supports our present data. On the contrary, there was no change in the rate of gastric emptying reported after endoscopic submucosal dissection in early gastric cancer patients (6). This observation may be explained by differing effects on the muscle layers, which plays an important role in moving the digested food to the duodenum.…”

Section: Discussionmentioning

confidence: 94%

“…However, Higuchi et al (6) found that endoscopic submucosal dissection preserved gastric emptying in patients with early gastric cancer. Ulcers have been defined histologically as a lesion that penetrates the muscularis mucosae and the muscle layer at the base of the mucosa.…”

Section: Introductionmentioning

confidence: 99%

Gastric emptying after artificial ulceration in rats: differences due to the site of the ulcer and the effects of prokinetic drugs

Uchida

Kobayashi

Shimizu

2017

J. Smooth Muscle Res.

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Background This study aimed to evaluate the effects of the position of an acetic acid-induced gastric ulcer and the effects of prokinetic drugs on gastric emptying. Materials and Methods Male Sprague-Dawley rats were used in this study. Acetic acid ulcers were induced either in the region between the fundus and pylorus on the anterior wall of the stomach or in the glandular region on the greater curvature of the stomach to determine whether there were regional differences in the effect of the ulcers. Gastric emptying was evaluated with a breath test using [1-13C] acetic acid. In addition, the effects of the prokinetic drugs, metoclopramide and mosapride, on gastric emptying were also evaluated. Results Acetic acid induced ulcers in the region between the fundus and pylorus on the anterior wall of the stomach significantly delayed gastric emptying as compared with control rats, but not the acetic acid induced ulcers in the glandular region on the greater curvature of the stomach. Metoclopramide and mosapride did not improve the delayed gastric emptying even at doses that enhanced gastric emptying in normal rats. Conclusion These findings show that gastric emptying is influenced by the position of the ulcer and the region between the fundus and pylorus on the anterior wall plays an important role in gastric emptying. Moreover, it was found that metoclopramide and mosapride do not improve the delayed gastric emptying caused by acetic acid ulcers induced on the anterior wall in the region between the fundus and pylorus.

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“…They concluded that local steroid injection might promote the formation of flat and sufficient granulation tissue without fibrotic contraction, which caused less deformity in the stomach. Higuchi et al [30] investigated whether gastric motility was affected by ESD. Their study revealed that ESD did not significantly affect any of the gastric emptying parameters measured by the [ 13 C]octanoic acid breath test.…”

Section: Complications and Their Preventionmentioning

confidence: 99%

“…Regarding other complications, three studies were identified [28][29][30]. Watari et al [28] investigated the incidence of ''silent'' free air and aspiration pneumonia detected by CT after ESD.…”

Section: Complications and Their Preventionmentioning

confidence: 99%

Updated evidence on endoscopic resection of early gastric cancer from Japan

et al. 2016

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Preserved gastric motility in patients with early gastric cancer after endoscopic submucosal dissection

Abstract: ESD is an effective treatment for EGC both in preserving organs and gastric motility.

Cited by 10 publications

References 14 publications

Complementary and Alternative Medicine Use and Its Association with Emotional Status and Quality of Life in Patients with a Solid Tumor: A Cross-Sectional Study

Complementary and Alternative Medicine Use and Its Association with Emotional Status and Quality of Life in Patients with a Solid Tumor: A Cross-Sectional Study

Gastric emptying after artificial ulceration in rats: differences due to the site of the ulcer and the effects of prokinetic drugs

Updated evidence on endoscopic resection of early gastric cancer from Japan

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