Preserved Human Amniotic Membrane Transplantation in the Treatment of Primary Pterygium

Abstract

* BACKGROUND AND OBJECTIVE: To assess the outcome of simple excision with preserved human amniotic membrane transplantation in the treatment of primary pterygium. * PATIENTS AND METHODS: A total of 59 eyes with primary pterygium underwent surgical excision. In Group 1 , 28 eyes were treated with simple excision and preserved human amniotic membrane transplantation. In Group 2, 3 1 eyes were treated with bare sclera excision. These two groups were compared in recurrence, final appearance of the operation site, and complications. Patients were followed for at least 10 months. * RESULTS: During a mean follow up of 14.9 months, we observed 3 (10.7%) recurrences in Group 1 and 20 (38.7%) recurrences in Group 2 (P:0.03). In Group 1, 20 (71.4%) eyes and 14 (45.2%) eyes in Group 2 had a satisfactory final operation site appearance (P:0.04l). No serious complication was observed in both groups. * CONCLUSION: Simple excision and preserved human amniotic membrane transplantation appears to be a safe and effective way of treating primary pterygium because of the lack of serious complications and a relatively low rate of recurrence. [Ophthalmic Surg Lasers 2001;32:464-469]

Collagen-Based Artificial Cornea for Lamellar Keratoplasty: An Early Case Report

“…7 The reported risk of recurrence with amniotic membrane is 3% to 15% for primary pterygia and 9.5% to 38% for recurrent pterygia. [8][9][10][11] However, the amniotic membrane has limitations, such as the inability to maintain stromal transparency in layer-by-layer keratoplasty.…”

Intraoperative Ethanol Treatment as an Adjuvant Therapy of Pterygium Excision

“…The procedure of ethanol application was modified from the LASEK method originally described by Massino Camellin, MD (M. Cimberele, "LASEK Has More Than 1 Year of Successful Experience" , Ocular Surgery News, July 15, 2000, pp. [14][15][16][17]. The methods of MMC treatment were the same as those described by Wong VA et al (43) Preparations for the surgery and the technique for pterygium excision were the same in all cases.…”

“…However, the recurrence rate after this procedure is unacceptably high, 30-89% (2)(3)(4). In search of a more effective and safe method for prevent-ORIGINAL ARTICLE ing pterygium recurrence after surgical excision, many adjuvant therapies have been investigated such as Sr-90 beta-radiation (6), soft X-ray irradiation (7) intraoperative and post-operative mitomycin C (MMC) (3,4,(8)(9)(10), subconjunctival injection of steroid (11) or 5-fluorouracil (12), conjunctival or limbal-conjunctival autograft transplantation, (13,14), amniotic membrane transplantation (15,16), split thickness buccal mucous membrane grafts (17), and excimer laser treatment (18). Many possible models of pterygium formation have been proposed, in which immunological reactions (20)(21)(22)(23), potential oncogenic virus infections (24)(25)(26), degeneration processes (26,27), ultraviolet irradiation, and neoplastic mechanisms (19,25,28,29) participate in a multi-step process of pterygium pathogenesis.…”