Preserved individual differences in functional connectivity patterns under dexmedetomidine-induced sedation

Liu, Haiyang; Jian, Minyu; Liu, Shu; Li, Ang; Li, Shaowu; Fang, Jinghan; Liang, Fa; Liu, Bing; Han, Ruquan

doi:10.1016/j.neulet.2019.134289

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Consistent with previous findings 15,28 , this study demonstrates a high level of inter-individual variability in association cortices and a lower level in primary cortices, both in the awake and anesthetized states. The inter-individual variability is reduced, but functional connectomes remain preserved during anesthesia, which is in line with previous research 40 . The inter-individual variability in functional connectomes can be attributed to two types of factors 41,42 .…”

Section: The Effects Of Anesthesia On Individual Variability and Conn...supporting

confidence: 92%

Subject-specific brain functional fingerprints are preserved during general anesthesia

Liu,

Fu,

Ren

et al. 2023

Preprint

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Functional MRI often requires general anesthesia for noncompliant individuals. However, it remains unclear how anesthesia affects brain network organization and whether individuals’ idiosyncratic functional fingerprints remain identifiable. Here, we performed individualized analyses on prolonged fMRI data (96 minutes) collected from 14 participants in both awake and anesthetized states. We found that functional connectivity in the primary sensorimotor, visual and auditory cortices was particularly susceptible to anesthesia. Within- and between-network connectivity was generally reduced under anesthesia, indicating weakened integration. Individual differences in connectivity profile were diminished, however, subject-specific functional fingerprints were well-preserved and highly identifiable, especially in the association cortices. A model was developed to reconstruct individuals’ awake connectomes using anesthesia data. The model's ability to identify autism-related dysfunctions in social network was demonstrated using data from 29 anesthetized, autistic children. This work revealed anesthetic effects on functional connectivity, and established a reconstructive model that may bridge conscious and unconscious states.

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Section: The Effects Of Anesthesia On Individual Variability and Conn...supporting

confidence: 92%

Subject-specific brain functional fingerprints are preserved during general anesthesia

Liu,

Fu,

Ren

et al. 2023

Preprint

View full text Add to dashboard Cite

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Dynamic reconfiguration of human brain networks across altered states of consciousness

Liu

Peng

et al. 2022

Behavioural Brain Research

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Changes in Intrinsic Connectivity Networks Topology Across Levels of Dexmedetomidine-Induced Alteration of Consciousness

Staquet,

Vanhaudenhuyse,

Kandeepan

et al. 2024

Anesthesia &Amp; Analgesia

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BACKGROUND: Human consciousness is generally thought to emerge from the activity of intrinsic connectivity networks (resting-state networks [RSNs]) of the brain, which have topological characteristics including, among others, graph strength and efficiency. So far, most functional brain imaging studies in anesthetized subjects have compared wakefulness and unresponsiveness, a state considered as corresponding to unconsciousness. Sedation and general anesthesia not only produce unconsciousness but also phenomenological states of preserved mental content and perception of the environment (connected consciousness), and preserved mental content but no perception of the environment (disconnected consciousness). Unresponsiveness may be seen during unconsciousness, but also during disconnectedness. Deep dexmedetomidine sedation is frequently a state of disconnected consciousness. In this study, we were interested in characterizing the RSN topology changes across 4 different and steady-state levels of dexmedetomidine-induced alteration of consciousness, namely baseline (Awake, drug-free state), Mild sedation (drowsy, still responding), Deep sedation (unresponsive), and Recovery, with a focus on changes occurring between a connected consciousness state and an unresponsiveness state. METHODS: A functional magnetic resonance imaging database acquired in 14 healthy volunteers receiving dexmedetomidine sedation was analyzed using a method combining independent component analysis and graph theory, specifically looking at changes in connectivity strength and efficiency occurring during the 4 above-mentioned dexmedetomidine-induced altered consciousness states. RESULTS: Dexmedetomidine sedation preserves RSN architecture. Unresponsiveness during dexmedetomidine sedation is mainly characterized by a between-networks graph strength alteration and within-network efficiency alteration of lower-order sensory RSNs, while graph strength and efficiency in higher-order RSNs are relatively preserved. CONCLUSIONS: The differential dexmedetomidine-induced RSN topological changes evidenced in this study may be the signature of inadequate processing of sensory information by lower-order RSNs, and of altered communication between lower-order and higher-order networks, while the latter remain functional. If replicated in an experimental paradigm distinguishing, in unresponsive subjects, disconnected consciousness from unconsciousness, such changes would sustain the hypothesis that disconnected consciousness arises from altered information handling by lower-order sensory networks and altered communication between lower-order and higher-order networks, while the preservation of higher-order networks functioning allows for an internally generated mental content (or dream).

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Preserved individual differences in functional connectivity patterns under dexmedetomidine-induced sedation

Cited by 3 publications

References 25 publications

Subject-specific brain functional fingerprints are preserved during general anesthesia

Subject-specific brain functional fingerprints are preserved during general anesthesia

Dynamic reconfiguration of human brain networks across altered states of consciousness

Changes in Intrinsic Connectivity Networks Topology Across Levels of Dexmedetomidine-Induced Alteration of Consciousness

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