2022
DOI: 10.1177/13524585221094478
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Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis

Abstract: Background: Optimal management of anti-CD20-treated patients with multiple sclerosis (pwMS) is an important clinical task during the current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Objectives: To characterize humoral and cellular immune responses to SARS-CoV-2 vaccinations/infections in a longitudinal cohort of anti-CD20 treated ( n = 175) and anti-CD20 therapy-naïve ( n = 41) pwMS. Methods: Anti-SARS-CoV-2 spike protein immunoglobulin G (IgG) and IgA, virus neutralizing capacity… Show more

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Cited by 18 publications
(36 citation statements)
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“…Maintained SARS-CoV-2 specific T cell responses after three and four vaccinations are consistent with findings after two vaccinations 4 , and appear relevant as vaccine-induced T memory cells cross-recognize Omicron variants. 14,15 Limitations of this study are the rather small number of anti-CD20 treated pwMS vaccinated four times and the lack of absolute B cell counts.…”
Section: Discussionsupporting
confidence: 81%
See 4 more Smart Citations
“…Maintained SARS-CoV-2 specific T cell responses after three and four vaccinations are consistent with findings after two vaccinations 4 , and appear relevant as vaccine-induced T memory cells cross-recognize Omicron variants. 14,15 Limitations of this study are the rather small number of anti-CD20 treated pwMS vaccinated four times and the lack of absolute B cell counts.…”
Section: Discussionsupporting
confidence: 81%
“…Maintained SARS-CoV-2 specific T cell responses after three and four vaccinations are consistent with findings after two vaccinations 4 , and appear relevant as vaccine-induced T memory cells cross-recognize Omicron variants. 14,15…”
Section: Discussionsupporting
confidence: 81%
See 3 more Smart Citations