Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers

Cañete, Toni

doi:10.3389/fnagi.2021.683412

Cited by 5 publications

(6 citation statements)

References 43 publications

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“…Literature, both in humans and rodents, shows that females have a lower pain threshold. Therefore, the pain sensitivity in females is higher than in males [49][50][51][52][53] . One researcher has the opposite opinion: From the point of view of the dentist, women have a higher tolerance to pain than men 54 .…”

Section: Discussionmentioning

confidence: 99%

Ganoderma tsuage promotes pain sensitivity in aging mice

Yang,

Lin,

et al. 2024

Sci Rep

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Advances in modern medicine have extended human life expectancy, leading to a world with a gradually aging society. Aging refers to a natural decline in the physiological functions of a species over time, such as reduced pain sensitivity and reaction speed. Healthy-level physiological pain serves as a warning signal to the body, helping to avoid noxious stimuli. Physiological pain sensitivity gradually decreases in the elderly, increasing the risk of injury. Therefore, geriatric health care receives growing attention, potentially improving the health status and life quality of the elderly, further reducing medical burden. Health food is a geriatric healthcare choice for the elderly with Ganoderma tsuage (GT), a Reishi type, as the main product in the market. GT contains polysaccharides, triterpenoids, adenosine, immunoregulatory proteins, and other components, including anticancer, blood sugar regulating, antioxidation, antibacterial, antivirus, and liver and stomach damage protective agents. However, its pain perception-related effects remain elusive. This study thus aimed at addressing whether GT could prevent pain sensitivity reduction in the elderly. We used a galactose-induced animal model for aging to evaluate whether GT could maintain pain sensitivity in aging mice undergoing formalin pain test, hot water test, and tail flexes. Our results demonstrated that GT significantly improved the sensitivity and reaction speed to pain in the hot water, hot plate, and formalin tests compared with the control. Therefore, our animal study positions GT as a promising compound for pain sensitivity maintenance during aging.

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Section: Discussionmentioning

confidence: 99%

Ganoderma tsuage promotes pain sensitivity in aging mice

Yang,

Lin,

et al. 2024

Sci Rep

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“…TASTPM (double-mutant A␤PPswe × 3 PS1.M146 V) mice, both male and female, show a reduced sensitivity to acute noxious heat stimuli but respond normally to peripheral inflammatory pain [8]. Finally, 3xTg-AD (PS1M146 V, A␤PPswe, tauP301 L transgenes) mice, both male and female, show a preserved response to thermal pain from asymptomatic to advanced stages of the disease, with females exhibiting an increased sensorydiscriminative pain sensitivity than their non-Tg counterpart [10].…”

Section: Discussionmentioning

confidence: 99%

“…Curiously, TASTPM mice respond normally to peripheral inflammatory pain [8], whereas CRND8 mice show a reduced sensitivity to it [9]. Unlike CRND8 and TASTPM mice, 3xTg-AD mice, bearing A␤PP, presenilin-1, and tau mutant trans-genes, show a preserved response to thermal pain from asymptomatic to advanced stages of the disease [10].…”

Section: Introductionmentioning

confidence: 99%

Increased Heat Pain Tolerance but Hyperalgesia to Tonic Inflammatory Pain in the CRND8 Mouse Model of Alzheimer’s Disease

Merlo,

Costa,

Chiechio

et al. 2023

JAD

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Background: The effects of Alzheimer’s disease (AD) pathology on the experience of pain are poorly understood. Objective: To understand the pathophysiological mechanisms underlying pain sensory transmission in the transgenic mouse model of AD, CRND8. Methods: We explored AD-related pathology in the spinal cord and dorsal root ganglia of 18-week-old female CRND8 mice. We assessed nociceptive responses to both acute heat stimuli and persistent inflammatory pain in CRND8 mice and non-transgenic (non-Tg) littermates. In addition, we searched for differences in biochemical correlates of inflammatory pain between CRND8 and non-Tg mice. Finally, we investigated the excitability of dorsal horn noc iceptive neurons in spinal cord slices from CRND8 and non-Tg mice. Results: We demonstrated the presence of intracellular AD-like pathology in the spinal cord and in the dorsal root ganglia nociceptive sensory neurons of CRND8 mice. We found that CRND8 mice had a reduced susceptibility to acute noxious heat stimuli and an increased sensitivity to tonic inflammatory pain. Tonic inflammatory pain correlated with a lack of induction of pro-opiomelanocortin in the spinal cord of CRND8 mice as compared to non-Tg mice. Electrophysiological recording in acute spinal cord slice preparations indicated an increased probability of glutamate release at the membrane of dorsal horn nociceptive neurons in CRND8 mice. Conclusion: This study suggests that an increased thermal tolerance and a facilitation of nociception by peripheral inflammation can coexist in AD.

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“…A heat source at 60 °C was located 0.5 cm under the hind paws of healthy or surgical rats for a maximum of 20 s. Paw withdrawal latencies were recorded, and three measurements were averaged for each animal. A cutoff latency of 20 s was imposed to avoid tissue damage [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

A grooved conduit combined with decellularized tissues for peripheral nerve regeneration

Chen

Huang

et al. 2023

J Mater Sci: Mater Med

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Peripheral nerve injury (PNI) is a common and severe clinical disease worldwide, which leads to a poor prognosis because of the complicated treatments and high morbidity. Autologous nerve grafting as the gold standard still cannot meet the needs of clinical nerve transplantation because of its low availability and limited size. The development of artificial nerve conduits was led to a novel direction for PNI treatment, while most of the currently developed artificial nerve conduits was lack biochemical cues to promote nerve regeneration. In this study, we designed a novel composite neural conduit by inserting decellularized the rat sciatic nerve or kidney in a poly (lactic-co-glycolic acid) (PLGA) grooved conduit. The nerve regeneration effect of all samples was analyzed using rat sciatic nerve defect model, where decellularized tissues and grooved PLGA conduit alone were used as controls. The degree of nerve regeneration was evaluated using the motor function, gastrocnemius recovery, and morphological and histological assessments suggested that the combination of a grooved conduit with decellularized tissues significantly promoted nerve regeneration compared with decellularized tissues and PLGA conduit alone. It is worth to note that the grooved conduits containing decellularized nerves have a promotive effect similar to that of autologous nerve grafting, suggesting that it could be an artificial nerve conduit used for clinical practice in the future. Graphical Abstract

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Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers

Cited by 5 publications

References 43 publications

Ganoderma tsuage promotes pain sensitivity in aging mice

Ganoderma tsuage promotes pain sensitivity in aging mice

Increased Heat Pain Tolerance but Hyperalgesia to Tonic Inflammatory Pain in the CRND8 Mouse Model of Alzheimer’s Disease

A grooved conduit combined with decellularized tissues for peripheral nerve regeneration

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