Pressure-actuated monolithic acrylic microfluidic valves and pumps

Guevara-Pantoja, Pablo E.; Valdés, Rocio Jimena Jiménez; García-Cordero, José L.; Caballero‐Robledo, Gabriel A.

doi:10.1039/c7lc01337j

Cited by 25 publications

(25 citation statements)

References 45 publications

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“…Polymers such as poly(methyl methacrylate) (PMMA), poly(carbonate) (PC), poly (amide) (PA), polyimide (PI), poly(vinylidene fluoride) (PVDF), polypyrole, and PDMS have been used for the fabrication of flexible micropumps [103,[149][150][151]. These polymers allow making relatively large devices, yet with micrometre resolution.…”

Section: Effect Of Flexibility On Pumpingmentioning

confidence: 99%

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Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Various materials with flexibility and stretchability have been used in flexible microfluidics. Flexible microchannels allow for strong fluid-structure interactions. Thus, they behave in a different way from rigid microchannels with fluid passing through them. This unique behaviour introduces new characteristics that can be deployed in microfluidic applications and functions such as valving, pumping, mixing, and separation. To date, a specialised review of flexible microfluidics that considers both the fundamentals and applications is missing in the literature. This review aims to provide a comprehensive summary including: (i) Materials used for fabrication of flexible microfluidics, (ii) basics and roles of flexibility on microfluidic functions, (iii) applications of flexible microfluidics in wearable electronics and biology, and (iv) future perspectives of flexible microfluidics. The review provides researchers and engineers with an extensive and updated understanding of the principles and applications of flexible microfluidics.

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Section: Effect Of Flexibility On Pumpingmentioning

confidence: 99%

“…Flexibility allows the micropump to fit well inside the tissue. Guevara-Pantoja et al fabricated all-PMMA microfluidic pumps that are thin enough to be flexible [150]. These micropumps can withstand high flow rates and pressures and do not leak as they are made entirely of a single material and well bonded.…”

Section: Effect Of Flexibility On Pumpingmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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“…Generally, poly(dimethylsiloxane) (PDMS) is the most commonly used membrane material due to its good optical transparency and high elasticity for large deformations [10]. Other materials, such as thermal plastic polymer [11,12], shape memory alloy [13,14], glass [15], and more are also used in certain situations. As for the deflection of the membrane, various mechanical [16,17], electrostatic [18,19], pneumatic [20,21], magnetic [22,23], piezoelectric [24], or thermal [25] mechanisms have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

Zhang

Oseyemi

2019

Micromachines

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The microvalve for accurate flow control under low fluidic pressure is vital in cost-effective and miniaturized microfluidic devices. This paper proposes a novel microfluidic passive valve comprising of a liquid chamber, an elastic membrane, and an ellipsoidal control chamber, which actualizes a high flow rate control under an ultra-low threshold pressure. A prototype of the microvalve was fabricated by 3D printing and UV laser-cutting technologies and was tested under static and time-dependent pressure conditions. The prototype microvalve showed a nearly constant flow rate of 4.03 mL/min, with a variation of ~4.22% under the inlet liquid pressures varied from 6 kPa to 12 kPa. In addition, the microvalve could stabilize the flow rate of liquid under the time-varying sinusoidal pressures or the square wave pressures. To validate the functionality of the microvalve, the prototype microvalve was applied in a gas-driven flow system which employed an air blower or human mouth blowing as the low-cost gas source. The microvalve was demonstrated to successfully regulate the steady flow delivery in the system under the low driving pressures produced by the above gas sources. We believe that this new microfluidic passive valve will be suitable for controlling fluid flow in portable microfluidic devices or systems of wider applications.

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“…One major application in microfluidic systems is control over fluid pressure within microfluidic channels. Applications of pressure driven flow include fluid based digital logic 10 , actuation of on-chip valves 17,29 , and control of laminar flow interfaces between fluids in a channel 1 . In order to test the ability of this pump to generate pressure for microfluidic applications, we used a Y-channel microfluidic device to track the position of a laminar flow interface over time.…”

Section: Resultsmentioning

confidence: 99%

Open-source, 3D-printed Peristaltic Pumps for Small Volume Point-of-Care Liquid Handling

Behrens

Fuller

Swist

et al. 2020

Sci Rep

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Microfluidic technologies are frequently employed as point-of-care diagnostic tools for improving time-to-diagnosis and improving patient outcomes in clinical settings. These microfluidic devices often are designed to operate with peripheral equipment for liquid handling that increases the cost and complexity of these systems and reduces their potential for widespread adoption in low resource healthcare applications. Here, we present a low-cost (~$120), open-source peristaltic pump constructed with a combination of three dimensional (3D)-printed parts and common hardware, which is amenable to deployment with microfluidic devices for point-of-care diagnostics. This pump accepts commonly available silicone rubber tubing in a range of sizes from 1.5 to 3 mm, and is capable of producing flow rates up to 1.6 mL min −1 . This device is programmed with an Arduino microcontroller, allowing for custom flow profiles to fit a wide range of low volume liquid handling applications including precision liquid aliquoting, flow control within microfluidics, and generation of physiologically relevant forces for studying cellular mechanobiology within microfluidic systems.Microfluidic systems are ubiquitous tools within science and engineering laboratories around the world that enable low-cost and high throughput analysis via the miniaturization and parallelization of experimental systems. To enable broader applications and lower the barrier to entry for using microfluidic technology, developing open-source and low-cost tools for handling fluids is a promising avenue of research 1-3 . Open-source microfluidic tools could be particularly impactful when used for point-of-care diagnostics in resource limited settings. The growing use of microfluidics in point-of-care diagnostic roles is driven by the desire for more personalized medical treatments that are tailored to the specific pathologies identified in the patient 4-7 . This is because assays that can be performed at the point of care dramatically improve time-to-diagnosis, leading to improvements in medical practitioner decision making and patient outcomes 8 . In order for point-of-care diagnostic devices to be widely adopted into more clinical settings so that they can effectively improve healthcare outcomes, advances must be made in key enabling technologies, including improved microfluidic device designs, and improved peripheral systems for fluid actuation and sensing 9 . Increasing the use of open-source tools for future point-of-care diagnostic tools would enable reductions in system cost, and increase ease of use.Microfluidic point-of-care diagnostic systems must include three basic components: the physical microfluidic device, systems to read the assay output, and systems to control the flow of liquid reagents (Fig. 1A). The physical microfluidic device can be manufactured from a wide range of low-cost materials, including PDMS 10

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Pressure-actuated monolithic acrylic microfluidic valves and pumps

Cited by 25 publications

References 45 publications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Microfluidic Passive Valve with Ultra-Low Threshold Pressure for High-Throughput Liquid Delivery

Open-source, 3D-printed Peristaltic Pumps for Small Volume Point-of-Care Liquid Handling

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