2014
DOI: 10.1007/s10439-014-1202-6
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Pressure Induced Deep Tissue Injury Explained

Abstract: The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This has led to a clear understanding on two damage mechanisms associated with the development of DTI. Direct deformation results from high, but physiologically relevant, strains and is a process that leads to the first si… Show more

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Cited by 169 publications
(143 citation statements)
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References 26 publications
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“…Waiting at the ED on a trolley may lead to increased risk for developing pressure ulcer. Research has informed us that cellular damage and thus the potential development of pressure ulcers can occur within a few minutes [16]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Waiting at the ED on a trolley may lead to increased risk for developing pressure ulcer. Research has informed us that cellular damage and thus the potential development of pressure ulcers can occur within a few minutes [16]. …”
Section: Discussionmentioning
confidence: 99%
“…A high number of these patients are in a fragile situation, with high age and suffering from multi-diseases leading to a complex situation. Also, recent biomedical research reveals that a direct deformation of tissue results from high strain, and is a process that leads to the first signs of cell damage within minutes [16]. Subsequently, patients in the ambulance or at the ED are exposed to high pressure ulcer risk [1719].…”
Section: Introductionmentioning
confidence: 99%
“…31 Pressure and shear forces applied to the wound can also lead to direct deformational damage to the wound as well as capillary closure leading to cellular disruption and microvascular damage arising from ischemia-reperfusion injury. 32 Scarring and the eventual mechanical properties of the healed wound are influenced by the extrinsic mechanical forces that are applied to the wound during proliferation and remodeling. 33,34 When appropriately applied extrinsic mechanical forces can lead to enhanced healing and potentially less scarring.…”
Section: Factors Affecting Wound Healingmentioning
confidence: 99%
“…Also it occurs due to a subject's physiological parameters such as body weight, height. Pressure ulcers mostly develop at bony areas (43% at sacrum, 11% at heel) compared to soft muscular area ) [9], [10]. Figure 1 shows the frequency of pressure ulcer occurrence in the human body.…”
Section: Introductionmentioning
confidence: 99%