A central problem in engineering of power-generating equipment, beside the quest for economy, is the problem of ensuring reliability of equipment and branched pipeline systems for circulation of process media. When analyzing causes of component failures in thermomechanical installations, flow control devices and pipelines, it should be noted that such failures most often result from dynamic loads on walls of these objects exposed to flowing media. Such loads are an immediate result of turbulent flow of the process medium. This turbulence is characterized by extremely non-uniform flow field and pressure pulsations of significant amplitude occurring in a broad band of frequencies. For that reason, this paper will be mainly concerned with the development and experimental studies of new approaches to dampening flow perturbations introduced by flow control devices, turbine stages, flow direction changes at pipeline bends, control valves of steam turbines etc. Findings are presented as specific examples showing the potential for a sharp reduction of dynamic loads on walls of various devices exposed to flowing medium. These involve both specially designed aerodynamic filters and direct action to modify flow behavior of the process medium in areas adjacent to walls. It is shown that the application of proposed pulsation dampener designs has the potential of twofold to threefold improvement in vibrational reliability of equipment and its interconnecting pipelines.