Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes

Celeiro, María; Lamas, J. Pablo; Garcı́a-Jares, Carmen; Llompart, Marı́a

doi:10.1016/j.chroma.2015.01.049

Cited by 53 publications

(35 citation statements)

References 22 publications

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“…Vaginal douches have been implicated as a source of DEP among reproductive-aged women [31]. Other products used intravaginally or in the genital area, such as lubricant [26], ultrasound gel [32], and wipes [33], may also be sources of phthalate exposure. These exposures are widespread: in nationally representative surveys of U.S. women, 25% reported using vaginal lubricants in the past month [34], 62% reported ever using lubricant [34], and 18% reported douching in the past year [35].…”

Section: Introductionmentioning

confidence: 99%

Phthalate exposure and odds of bacterial vaginosis among U.S. reproductive-aged women, NHANES 2001–2004

Geller

Brotman

O’Brien

et al. 2018

Reproductive Toxicology

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Endocrine-disrupting chemicals, such as phthalates, are an unexamined potential risk factor for bacterial vaginosis (BV) and warrant investigation because hormones affect BV. We examined the association between phthalate exposure and BV in the National Health and Nutrition Examination Survey, 2001-2004. BV outcomes were defined as intermediate (Nugent score of 4-6) and positive (7-10). Phthalate metabolites, including monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), and di(2-ethylhexyl) phthalate (DEHP) metabolites, were measured in urine. Among 854 women with complete data, multinomial logistic regression revealed that concentrations of MnBP (Q4 vs. Q1 OR = 3.01, 95% CI 1.76-5.15, p-trend <0.001) and ΣDEHP metabolites (Q4 OR = 2.55, 95% CI 1.45-4.47, p-trend = 0.03) were associated with Nugent-score BV, although only MnBP was significant after adjustment for confounders. Associations were null after adjustment for urinary creatinine (MnBP Q4 OR = 1.11, 95% CI 0.63-1.96; ΣDEHP Q4 OR = 0.72, 95% CI 0.37-1.39). Future work should further examine these relationships using direct measurements of intravaginal phthalates exposures.

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Section: Introductionmentioning

confidence: 99%

Phthalate exposure and odds of bacterial vaginosis among U.S. reproductive-aged women, NHANES 2001–2004

Geller

Brotman

O’Brien

et al. 2018

Reproductive Toxicology

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“…As described in the literature, benzyl alcohol, eugenol, and isoeugenol were also found in water , scented candles , toys , baby wipes , toothpaste , and personal care products . Thus, researchers should increase their attention on these fragrances.…”

Section: Resultsmentioning

confidence: 87%

Optimization of headspace for GC‐MS analysis of fragrance allergens in wooden children's products using response surface methodology

Wang

et al. 2019

Separation Science Plus

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Residual chemicals in wooden children's products may threaten children's health, but few studies have paid attention to it so far. In this study, a simple and green method was developed for the determination of volatile chemicals, especially the 48 fragrance allergens in wooden children's products using static headspace coupled with gas chromatography and mass spectrometry. Minimal amounts of sample (20 mg) and acetone solvent (40 μL) were used, and no additional sample pretreatment was performed except for freezing and grinding. Three factors (incubating temperature, equilibration time, pressing pressure) affecting headspace extraction were optimized by response surface methodology to obtain scientific results considering of the interactions among variables. Under the optimum detection conditions, this method was successfully validated for the analysis of fragrances. The proposed method showed limits of quantification within the range of 0.2–20 mg/kg. Recoveries ranged from 79.8 to 115.2%, and the relative standard deviation (n = 5) varied from 0.6 to 9.9%. Moreover, interferences caused by different sample matrices were investigated. The method was further applied to the analysis of 30 commercial wooden samples. Results demonstrated the existence of fragrances in wooden children's products. Benzyl alcohol, trans‐2‐heptenal, eugenol, and isoeugenol were the compounds with high detection rate.

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“…Studies have shown that these pigments are able to prevent premature aging and avoid diseases due to their antioxidant properties 1 . Pressurized Liquid Extraction (PLE) is efficient in phenolics recovery from plant matrices and uses controlled temperature and pressure, with the use of GRAS (Generally Recognized as Safe) 2 solvents. High ultrasound intensity is used to modify the physico-chemical matrix structure in order to accelerate the extraction.…”

Section: Introductionmentioning

confidence: 99%

Extraction of anthocyanins from Syrah grape (Vitis Vinifera L.) pomace using pressurized liquids assisted by ultrasound

2019

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Pressurized liquid extraction (PLE) is a clean technology able to extract valuable compounds from plant matrices that, when combined with ultrasound, appears as an appropriate technique to reduce the extraction time. In this context, the objective of this work was to obtain extracts with high concentrations of anthocyanins from grape residue using PLE assisted by ultrasound. In the PLE assisted by ultrasound, ultrasonic powers of 240, 400 and 520 W were evaluated. The power of 240 W produced extracts with higher content of monomeric anthocyanins, phenolic compounds and antioxidant capacity.

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Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes

Cited by 53 publications

References 22 publications

Phthalate exposure and odds of bacterial vaginosis among U.S. reproductive-aged women, NHANES 2001–2004

Phthalate exposure and odds of bacterial vaginosis among U.S. reproductive-aged women, NHANES 2001–2004

Optimization of headspace for GC‐MS analysis of fragrance allergens in wooden children's products using response surface methodology

Extraction of anthocyanins from Syrah grape (Vitis Vinifera L.) pomace using pressurized liquids assisted by ultrasound

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