Background
Psychological and social factors have been linked to stroke mortality; however, their impact on stroke disability is unclear. The purpose of this study was to evaluate the impact of pre-stroke fatalism, depressive symptoms, and social support on 90-day neurological, functional, and cognitive outcomes.
Methods
Ischemic strokes (2008–2011) were identified from the Brain Attack Surveillance in Corpus Christi Project. Validated scales were used to assess fatalism, depressive symptoms, and social support during baseline interviews. The National Institutes of Health Stroke Scale (NIHSS), Activities of Daily Living/ Instrumental Activities of Daily Living (ADL/IADL) scale, and Modified Mini-Mental State Exam (3MSE) were used to assess 90-day outcomes. The associations between the pre-stroke variables and 90-day outcomes were estimated from regression models adjusting for demographics, risk factors, tPA treatment, and comorbidities.
Results
Among 364 stroke survivors, higher pre-stroke fatalism was associated with worse functional (0.17 point higher ADL/IADL per IQR higher fatalism; CI 0.05, 0.30) and cognitive (2.81 point lower 3MSE per IQR higher fatalism; CI 0.95, 4.67) outcomes. Higher pre-stroke depressive symptoms were associated with worse functional (0.16 point higher ADL/IADL per IQR higher PHQ-9; CI 0.04, 0.28) and cognitive (2.28 point lower 3MSE per IQR higher PHQ-9; CI 0.46, 4.10) outcomes. Participants in the middle tertile of social support had better cognitive outcomes (3.75 points higher 3MSE; CI 0.93, 6.56) compared to the highest tertile.
Conclusions
The associations between pre-stroke fatalism, depressive symptoms, and social support and 90-day outcomes suggest that psychosocial factors play an important role in stroke recovery.