Presumed bilateral diffuse uveal melanocytic proliferation – A case report and review of literature

Parakh, Shweta; Maheshwari, Shrey; Das, Shrutanjoy; Kumar, Vinod; Agrawal, Rupesh; Gupta, Vishali; Mruthyunjaya, Prithvi; Luthra, Saurabh

doi:10.1016/j.ajoc.2022.101582

Cited by 6 publications

(2 citation statements)

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“…Since that time, approximately 100 cases have been reported in the literature and several comprehensive reviews of the subject have been published, including in depth descriptions of clinical findings. [5][6][7] Most patients were diagnosed with BDUMP between the sixth and seventh decade of life and had a variety of non-ocular cancers. A majority of malignancies in women have arisen in the urogenital tract (over 73%), while in men, lung tumors are most common (58%).…”

Section: Bilateral Diffuse Uveal Melanocytic Proliferationmentioning

confidence: 99%

“…The visual prognosis of BDUMP is poor with most patients suffering progressive bilateral visual loss usually attributed to a combination of exudative retinal detachments and cataract formation. [5][6][7] Protracted detachment of the macula will also result in secondary photoreceptor degeneration, another cause of subnormal vision whose individual contribution is difficult to estimate.…”

Section: Bilateral Diffuse Uveal Melanocytic Proliferationmentioning

confidence: 99%

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Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy

et al. 2022

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Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies. Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years. Study Design: Literature review with structured data abstraction. Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult. Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials.

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Section: Bilateral Diffuse Uveal Melanocytic Proliferationmentioning

confidence: 99%

Section: Bilateral Diffuse Uveal Melanocytic Proliferationmentioning

confidence: 99%