Presumed Rhegmatogenous Retinal Detachment in Patients With Retinoblastoma

Th, Lim; Dm, Robertson

doi:10.1097/00006982-200001000-00004

Cited by 20 publications

(9 citation statements)

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“…Other studies using similar techniques had a mixed final retina reattachment rate such as Tawansy et al 4 . (5 out of 14 cases), Bovey, 5 (2 out of 5 cases), Lim et al 6 . (3 out of 5 cases), Saumya et al 7 .…”

Section: Discussionmentioning

confidence: 95%

“…Complications like RD can occur during these treatments and cause practical difficulties in the management of Rb. Most of the published data about RD complicating Rb management occur following the use of EBRT along with systemic chemotherapy or other local cryoretinopexy or laser photocoagulation treatment 3, 4, 5, 6. There are a few case series of RD occurring during systemic chemotherapy with no EBRT 3, 4, 9, 10.…”

Section: Discussionmentioning

confidence: 99%

“…It has largely replaced external beam radiotherapy (EBRT) as the treatment of choice for conservative management of Rb 1, 2. Although the success rate of globe salvage techniques is improving, local ocular complications such as retinal detachment (RD) may complicate the Rb management at the time of diagnosis, during and after treatment 3, 4, 5, 6, 7, 8. Most RD cases in Rb are associated with the use of EBRT combined with other globe-conserving treatments such as systemic chemotherapy or local cryoretinopexy 3, 4, 5, 6.…”

Section: Introductionmentioning

confidence: 99%

“…Although the success rate of globe salvage techniques is improving, local ocular complications such as retinal detachment (RD) may complicate the Rb management at the time of diagnosis, during and after treatment 3, 4, 5, 6, 7, 8. Most RD cases in Rb are associated with the use of EBRT combined with other globe-conserving treatments such as systemic chemotherapy or local cryoretinopexy 3, 4, 5, 6. However, there are only a few reported studies of RD occurring during primary chemoreduction of Rb with no EBRT 3, 4, 7, 8, 9, 10.…”

Section: Introductionmentioning

confidence: 99%

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Management of retinal detachment in retinoblastoma with globe conserving treatment

Elaraoud

Ch'ng

Karl

et al. 2019

Journal of Current Ophthalmology

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Purpose To investigate the features and outcomes of retinoblastoma (Rb) patients complicated by development of retinal detachment (RD) following systemic chemotherapy with or without local focal consolidation treatment and without external beam radiotherapy (EBRT). Methods A retrospective study of all Rb patients between April 2002 and April 2012 at a tertiary hospital center (Birmingham Children’s Hospital and Birmingham Midlands Eye Centre, United Kingdom). All eyes that had developed RD during or after systemic treatment with or without local focal consolidation treatment were included in the study. The time interval between the type of treatment of Rb, development of RD and relevant surgical intervention were analyzed. Patients with exudative RD were treated conservatively through observation and patients with rhegmatogenous RD were treated with scleral buckling. Final anatomical retinal reattachment rate and visual acuity outcomes were analyzed. Results A total of 258 patients were treated for Rb over the 10-year period. One hundred sixty-nine patients were managed with globe conserving treatment. Ten (5.92%) eyes of 10 patients were complicated with RD. Five eyes were exudative or presumed exudative type of RD while the other five eyes were rhegmatogenous or presumed rhegmatogenous RD. In the exudative group, two patients achieved visual acuity (VA) of 0.2 Single Kays (20/32 Snellen), and the other two patients achieved 0.85 and 0.86 Crowded Kays (20/142 and 20/145 Snellen), respectively, after the RD had resolved. The last patient in the group had to be enucleated due to tumor recurrences. The median time for the exudative RD to resolve is 15 weeks (range, 4–36 weeks). In the rhegmatogenous group, 3 of the 4 operated patients achieved retinal reattachment. The final postoperative VA ranged between 0.05 Crowded Kays to 1.84 Crowded Kays (20/22 to 20/1384 Snellen). The other patient was treated conservatively as no retinal breaks were found with previous cryotherapy and thermotherapy. The final VA in this patient was hand movement, and the RD did not reattach. The median time for the rhegmatogenous RD to reattach is 6 weeks (range, 4–8 weeks). There were no intra- and postoperative complications. Conclusions With long-term conservative management through observation, exudative Rb after systemic treatment of Rb will tend to resolve by itself. However, supplementary local treatment with cryoretinopexy or laser photocoagulation during the systemic treatment of Rb can lead to an increased risk of rhegmatogenous RD. In these cases, most rhegmatogenous RD are successfully repaired with non-drainage scleral buckling and cryoretinopexy.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Management of retinal detachment in retinoblastoma with globe conserving treatment

Elaraoud

Ch'ng

Karl

et al. 2019

Journal of Current Ophthalmology

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“…While there are various reports of rhegmatogenous retinal detachment (RRD) after radiotherapy for intraocular tumor [ 1 2 3 ], to our knowledge, only 1 case of bilateral RRD after external beam radiotherapy has previously been reported. Herein, we report a rare case of nontraumatic bilateral RRD associated with radiotherapy for malignant lymphoma in the left frontal lobe.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Rhegmatogenous Retinal Detachment during External Beam Radiotherapy

Hidaka

Chuman

Nao‐i

2016

Case Rep Ophthalmol

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Herein, we report a case of nontraumatic bilateral rhegmatogenous retinal detachment (RRD) during external beam radiotherapy for nonocular tumor, presented as an observational case study in conjunction with a review of the relevant literature. A 65-year-old male was referred to our hospital due to bilateral RRD. He underwent a biopsy for a tumor of the left frontal lobe 4 months prior to presentation, and the tumor had been diagnosed as primary central nerve system B-cell type lymphoma. He received chemotherapy and external beam radiotherapy for 1 month. There were no traumatic episodes. Bilateral retinal detachment occurred during a series of radiotherapies. Simultaneous nontraumatic bilateral retinal detachment is rare. The effects of radiotherapy on ocular functionality, particularly in cases involving retinal adhesion and vitreous contraction, may include RRD. Thus, it is necessary to closely monitor the eyes of patients undergoing radiotherapy, particularly those undergoing surgery for retinal detachment and those with a history of photocoagulation for retinal tears, a relevant family history, or risk factors known to be associated with RRD.

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Intraocular Surgery After Treatment of Retinoblastoma

Honavar¹

2001

Arch Ophthalmol

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To analyze the results of intraocular surgery in patients treated for retinoblastoma and to assess the ocular and systemic outcomes. Design: Retrospective noncomparative case series. Patients: Forty-five consecutive patients who underwent an introcular surgery after treatment for retinoblastoma. Main Outcome Measures: (1) Recurrence of retinoblastoma, (2) need for enucleation, and (3) systemic metastasis. Overall outcome was defined as favorable in the absence of any of these measures and unfavorable in the presence of 1 or more. Results: Thirty-four patients (76%) underwent a single procedure of cataract surgery, a scleral buckling procedure, or pars plana vitrectomy and 11 (24%) underwent a combination of 2 or more surgical procedures. In all, 16 patients (36%) achieved final visual acuity better than 20/200. Unfavorable outcomes included recurrence of retinoblastoma in 14 patients (31%), enucleation in 16 (36%), and systemic metastasis in 3 (7%). Five patients (20%) who underwent cataract surgery, 5 (63%) who underwent a scleral buckling procedure, and 9 (75%) who underwent pars plana vitrectomy manifested an unfavorable outcome. The median interval between completion of treatment for retinoblastoma and intraocular surgery was 26 months in patients with a favorable outcome vs 6 months in those with an unfavorable outcome. Conclusions: Intraocular surgery after treatment for retinoblastoma may be justified in certain exceptional clinical situations. Cataract surgery is safe and effective in most cases. However, the need for a scleral buckling procedure and pars plana vitrectomy may be associated with a higher risk for recurrence of retinoblastoma, enucleation, and systemic metastasis, and a cautious approach is warranted.

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Presumed Rhegmatogenous Retinal Detachment in Patients With Retinoblastoma

Abstract: Presumed rhegmatogenous RD may occur after external beam radiation or cryotherapy for retinoblastoma. It poses special challenges in management.

Cited by 20 publications

References 0 publications

Management of retinal detachment in retinoblastoma with globe conserving treatment

Management of retinal detachment in retinoblastoma with globe conserving treatment

Bilateral Rhegmatogenous Retinal Detachment during External Beam Radiotherapy

Intraocular Surgery After Treatment of Retinoblastoma

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