Presumptive paraneoplastic exfoliative dermatitis in four domestic rabbits

Prélaud, A. Rostaher; Lee, A. Jassies-van der; Mueller, Ralf S.; Zeeland, Yvonne R.A. van; Bettenay, S. V.; Majzoub, M.; Zenker, I.; Hein, J.

doi:10.1136/vr.101226

Cited by 10 publications

(4 citation statements)

References 23 publications

(18 reference statements)

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Section: Inflammationmentioning

confidence: 99%

“…Comments: Generalized "exfoliative dermatitis" or "sebaceous adenitis" characterized by sebaceous gland atrophy, perifollicular, dermal, and/or epidermal lymphocytic infiltrates, and hyperkeratosis has been reported in rabbits 65,83,110,[118][119][120] . An association with concurrent thymoma or thymic lymphoma was noted in several cases 110,118,120 . Rabbits have been noted to be more sensitive to petroleum jelly-induced dermal irritation than rodents and minipigs, while rabbits and rats are more sensitive than minipigs to a topical antibiotic applied to abraded skin 121 .…”

Section: Inflammationmentioning

confidence: 99%

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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand. asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Inflammationmentioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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“…It is often secondary to inflammation caused by ectoparasites such as mites and lice, and dermatophytosis. An exfoliative dermatitis has been associated with sebaceous adenitis and thymoma, with rabbits presenting with generalised scaling, alopecia and erythema of the skin (Prélaud and others 2013).…”

Section: Common Clinical Presentationsmentioning

confidence: 99%

Guide to skin diseases in rabbits

Benato¹

2019

In Practice

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Background: Dermatological conditions are a very common presentation of pet rabbits to the veterinarian. The aetiology varies; problems such as pododermatitis and parasitic and bacterial infections constitute a higher percentage of these cases, while viral infections are considered less common. Stress and pain also play an important role and should be considered during the initial consultation and treatment planning.Aim of the article: This article provides an overview of skin diseases that may be presented to general veterinary practitioners, helping the practitioner to approach these cases with more confidence.

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“…These tumours rarely metastasize, 3 but they may result in life‐threatening respiratory and circulatory compromise due to their action as space‐occupying thoracic masses. Clinical signs include dyspnoea, exophthalmos, third eyelid prolapse and exfoliative dermatitis 2,4–9 . Suggested treatment options include corticosteroids, aspiration of cystic components of the mass, radiation therapy (RT) and surgical excision 1,2,4,5,7,10–13 .…”

Section: Introductionmentioning

confidence: 99%

Adaptive radiation therapy using weekly hypofractionation for thymoma treatment: A retrospective study of 10 rabbits

McCready

Poirier

Fleck

et al. 2022

Vet Comparative Oncology

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Radiation therapy (RT) is being utilized more commonly for rabbit thymomas due to high perioperative mortality rates with surgery. Median overall survival times reported for rabbit thymomas treated with a variety of RT protocols and techniques range from 6 months to greater than 2 years. As thymomas are radiation‐responsive tumours and may shrink rapidly after RT, adaptive radiotherapy (ART) is often warranted. The purpose of this single‐institution retrospective case series was to investigate the tumour volume reduction during RT, the frequency of replanning during RT, and survival time in rabbit thymomas treated using intensity‐modulated/image‐guided radiation therapy (IMRT/IGRT) and a weekly hypofractionated protocol delivering a total dose of 30 Gy. Ten rabbits met the inclusion criteria from October 2014 to October 2019. The median progression‐free survival was 561 days and the median overall survival was 634 days (range: 322–1118 days). The tumour volume gradually decreased with each RT fraction. On post‐hoc analysis, only the first RT fraction was associated with a significant GTV reduction (of more than 50% on average, p < .001). All subsequent RT fractions did not further reduce the GTV significantly (p > .06). Hypofractionated RT using a weekly protocol of 5 fractions of 6 Gy is a reasonable option to treat rabbit thymomas and replanning should be anticipated. The results of this study support the use of RT to rapidly relieve thymoma‐induced dyspnoea in rabbits.

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Presumptive paraneoplastic exfoliative dermatitis in four domestic rabbits

Cited by 10 publications

References 23 publications

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

Guide to skin diseases in rabbits

Adaptive radiation therapy using weekly hypofractionation for thymoma treatment: A retrospective study of 10 rabbits

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