Presurgical evaluation and surgical outcome of temporal lobe epilepsy

Salanova, Vicenta; Markand, Omkar N.; Worth, Robert M.; Garg, Bhuwan P.; Patel, Hema; Asconapé, Jorge J.; Park, Hee Myung; Hutchins, Gary D.; Smith, R. D.; Azzarelli, Biagio

doi:10.1016/s0887-8994(98)00128-3

Cited by 41 publications

(27 citation statements)

References 18 publications

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“…The intense neuronal activity during seizures can induce high amounts of Zn 2+ in the synaptic cleft, [13], [14] promoting reactive oxygen species (ROS) production, [15] which can ultimately lead to hippocampal neuronal death [16], [17], [14], [15], [13]. In fact, studies in hippocampi from TLE patients who underwent epilepsy surgery have shown neuronal loss [18], [19], [20], increased glial reaction [21], [22], [23], [24] and reorganization of mossy fibers axon collaterals into the inner molecular layer of the granule cell dendrites [25], [19]. This synaptic reorganization of Zn 2+ -enriched terminals has been hypothesized to contribute to synchronous firing and epileptiform activity [19].…”

Section: Introductionmentioning

confidence: 99%

Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy

et al. 2012

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In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) and patients with TLE associated with tumor or dysplasia (TLE-TD) were evaluated for expression of MT-I/II, for the vesicular zinc levels, and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis, microgliosis and reduced neuronal population. In TLE-TD, the same changes were observed, except that were mainly confined to fascia dentata. Increased vesicular zinc was observed only in the inner molecular layer of MTLE patients, when compared to control cases. Correlation and linear regression analyses indicated an association between increased MT-I/II and increased astrogliosis in TLE. MT-I/II levels did not correlate with any clinical variables, but MTLE patients with secondary generalized seizures (SGS) had less MT-I/II than MTLE patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from TLE patients and our data suggest that it is associated with astrogliosis and may be associated with different seizure spread patterns.

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Section: Introductionmentioning

confidence: 99%

Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy

et al. 2012

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“…Fluorodeoxyglucose-positron emission tomography (FDG-PET) scans and volumetric head magnetic resonance imaging scans (MRIs) were available in our program since 1993 and 1994, respectively (10). Patients also underwent the intracarotid amobarbital procedure (11).…”

Section: Methodsmentioning

confidence: 99%

Temporal Lobe Epilepsy Surgery: Outcome, Complications, and Late Mortality Rate in 215 Patients

2002

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Summary: Purpose:We studied the surgical outcome, complications, and the late mortality rate in a large group of patients with medically refractory temporal lobe epilepsy (TLE).Methods: Two-hundred fifteen patients with TLE were treated surgically between 1984 and 1999 after a comprehensive presurgical evaluation. Patients were followed up at 6 weeks, 3-6 months, and yearly thereafter. In addition, questionnaires were sent on the anniversary of their surgery. Surgical outcome (Engel's classification), complication rate, and factors contributing to late mortality were analyzed. Standardized mortality ratios (SMRs) were calculated.

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“…There is a history of birth difficulty or childhood febrile seizures in as many as three quarters of cases of temporal lobe epilepsy [28]. In recent years it has been shown that HS can be demonstrated on MRI [9, 10, 11, 12, 13, 15, 19, 20]. Studies examining the degree of MRI hippocampal volume loss, an indicator of HS, have shown no relationship with duration of epilepsy but a significant relationship to age at onset of epilepsy [7, 29].…”

Section: Discussionmentioning

confidence: 99%

“…There are reports of the MRI demonstration of HS in children [6, 8, 12, 13, 14, 15, 16, 17, 18, 19], the youngest being 9 months old [20], and pathological confirmation in resection specimens [15, 16, 19, 21, 22, 23, 24]in children as young as 2 years [25]. We describe the case of a girl aged 2 years and 3 months with seizures for 20 months who underwent a temporal resection and had HS demonstrated histopathologically.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Sclerosis in a Two-Year-Old with Temporal Lobe Epilepsy: Case Report with Pathological Confirmation

et al. 2000

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Presurgical evaluation and surgical outcome of temporal lobe epilepsy

Cited by 41 publications

References 18 publications

Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy

Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy

Temporal Lobe Epilepsy Surgery: Outcome, Complications, and Late Mortality Rate in 215 Patients

Hippocampal Sclerosis in a Two-Year-Old with Temporal Lobe Epilepsy: Case Report with Pathological Confirmation

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