Presynaptic glutamate receptors in nociception

Xie, Rou-Gang; Xu, Guang-Yin; Wu, Sheng-Xi; Luo, Ceng

doi:10.1016/j.pharmthera.2023.108539

Cited by 6 publications

(3 citation statements)

References 348 publications

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“…More studies are warranted to unveil the therapeutic potential of mGluR modulators which, compared to ionotropic glutamate receptor drugs, have the advantage to offer the possibility to fine tune glutamatergic transmission. Indeed, it must be recognized that glutamatergic transmission is distributed throughout the central nervous system and plays crucial roles in several brain functions, ranging from mood to memory and cognition [ 3 , 4 , 5 ]. Thus, if on one hand glutamatergic drugs have a high therapeutic potential in diseases associated with alterations of neuroplasticity, on the other hand, they might induce dangerous effects.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Glutamate (or glutamic acid) is a positively charged non-essential amino acid which, besides its metabolic roles [ 1 ], also represents the most important excitatory neurotransmitter in the central nervous system (CNS), where it drives approximately 70% of synapses [ 2 ]. The neurotransmitter glutamate regulates various brain processes ranging from cognitive functions, such as learning and memory, to mood, control of the sleep–wake cycle, pain perception, and motor function [ 3 , 4 , 5 ]. Glutamatergic transmission is mediated by specific ionotropic and metabotropic receptors located both at postsynaptic and presynaptic terminals.…”

Section: Introductionmentioning

confidence: 99%

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Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders

Nicosia,

Giovenzana,

Misztak

et al. 2024

IJMS

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Glutamate is the main excitatory neurotransmitter in the brain wherein it controls cognitive functional domains and mood. Indeed, brain areas involved in memory formation and consolidation as well as in fear and emotional processing, such as the hippocampus, prefrontal cortex, and amygdala, are predominantly glutamatergic. To ensure the physiological activity of the brain, glutamatergic transmission is finely tuned at synaptic sites. Disruption of the mechanisms responsible for glutamate homeostasis may result in the accumulation of excessive glutamate levels, which in turn leads to increased calcium levels, mitochondrial abnormalities, oxidative stress, and eventually cell atrophy and death. This condition is known as glutamate-induced excitotoxicity and is considered as a pathogenic mechanism in several diseases of the central nervous system, including neurodevelopmental, substance abuse, and psychiatric disorders. On the other hand, these disorders share neuroplasticity impairments in glutamatergic brain areas, which are accompanied by structural remodeling of glutamatergic neurons. In the current narrative review, we will summarize the role of glutamate-induced excitotoxicity in both the pathophysiology and therapeutic interventions of neurodevelopmental and adult mental diseases with a focus on autism spectrum disorders, substance abuse, and psychiatric disorders. Indeed, glutamatergic drugs are under preclinical and clinical development for the treatment of different mental diseases that share glutamatergic neuroplasticity dysfunctions. Although clinical evidence is still limited and more studies are required, the regulation of glutamate homeostasis is attracting attention as a potential crucial target for the control of brain diseases.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders

Nicosia,

Giovenzana,

Misztak

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Glutamate is an essential neurotransmitter involved in pain conditions, and its signaling pathways are associated with central sensitization and the development of neuropathic pain (Pereira and Goudet, 2018). Moreover, stimulation of peripheral glutamate receptors leads to peripheral sensitization and nociceptive behavior (Xie et al, 2023). Several pain conditions, such as migraine and fibromyalgia, have been associated with increased levels of glutamate (Park & Chu, 2022;Pyke et al, 2017).…”

Section: Botulinum Neurotoxin Suppressed the Release Of Pain Mediatorsmentioning

confidence: 99%

Cellular and molecular mechanisms involved in the analgesic effects of botulinum neurotoxin: A literature review

Hosseindoost,

Inanloo,

Pestehei

et al. 2024

Drug Development Research

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Botulinum neurotoxins (BoNTs), derived from Clostridium botulinum, have been employed to treat a range of central and peripheral neurological disease. Some studies indicate that BoNT may be beneficial for pain conditions as well. It has been hypothesized that BoNTs may exert their analgesic effects by preventing the release of pain‐related neurotransmitters and neuroinflammatory agents from sensory nerve endings, suppressing glial activation, and inhibiting the transmission of pain‐related receptors to the neuronal cell membrane. In addition, there is evidence to suggest that the central analgesic effects of BoNTs are mediated through their retrograde axonal transport. The purpose of this review is to summarize the experimental evidence of the analgesic functions of BoNTs and discuss the cellular and molecular mechanisms by which they can act on pain conditions. Most of the studies reviewed in this article were conducted using BoNT/A. The PubMed database was searched from 1995 to December 2022 to identify relevant literature.

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Evolutionary and functional analysis of metabotropic glutamate receptors in lampreys

Zhuang,

Yan,

Gao

et al. 2024

Fish Physiol Biochem

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Presynaptic glutamate receptors in nociception

Cited by 6 publications

References 348 publications

Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders

Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders

Cellular and molecular mechanisms involved in the analgesic effects of botulinum neurotoxin: A literature review

Evolutionary and functional analysis of metabotropic glutamate receptors in lampreys

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