Presynaptic inhibition: the mechanism of protection from habituation of the crayfish lateral giant fibre escape response.

Bryan, Joan S.; Krasne, Franklin B.

doi:10.1113/jphysiol.1977.sp012005

Cited by 53 publications

(11 citation statements)

References 44 publications

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“…However, presynaptic inhibition of mechanosensory afferents ( Fig. 29; Kirk, 1985) greatly reduces the extent to which activity-dependent synaptic depression develops, and thereby protects the reflex from habituating to the stimulation produced by rapid movement through the water (Bryan and Krasne, 1977a;Bryan and Krasne, 1977b). These results demonstrated for the first time that central neural networks can not only regulate their own input, but moreover they can helpfully modulate their own plastic mechanisms.…”

Section: Protection Of the Synapse (During Tail Flip)mentioning

confidence: 81%

Adaptive motor control in crayfish

Cattaert

Ray

2001

Progress in Neurobiology

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This article reviews the principles that rule the organization of motor commands that have been described over the past five decades in crayfish. The adaptation of motor behaviors requires the integration of sensory cues into the motor command. The respective roles of central neural networks and sensory feedback are presented in the order of increasing complexity. The simplest circuits described are those involved in the control of a single joint during posture (negative feedback-resistance reflex) and movement (modulation of sensory feedback and reversal of the reflex into an assistance reflex). More complex integration is required to solve problems of coordination of joint movements in a pluri-segmental appendage, and coordination of different limbs and different motor systems. In addition, beyond the question of mechanical fitting, the motor command must be appropriate to the behavioral context. Therefore, sensory information is used also to select adequate motor programs. A last aspect of adaptability concerns the possibility of neural networks to change their properties either temporarily (such on-line modulation exerted, for example, by presynaptic mechanisms) or more permanently (such as plastic changes that modify the synaptic efficacy). Finally, the question of how "automatic" local component networks are controlled by descending pathways, in order to achieve behaviors, is discussed.

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Section: Protection Of the Synapse (During Tail Flip)mentioning

confidence: 81%

Adaptive motor control in crayfish

Cattaert

Ray

2001

Progress in Neurobiology

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“…fibres. The conductance increase and associated excitability decrease would then be restricted to the terminal regions but the consequent depolarization would spread electrotonically further back along the preterminal axon where excitability would be increased (see Bryan & Krasne, 1977;Nicoll & Alger, 1979). Thus, an increase in excitability would be the observed effect of conditioning if the excitability test stimulus activated fibres in the preterminal region, a situation made more likely by the simultaneous decrease in excitability of the terminals themselves.…”

Section: Discussionmentioning

confidence: 99%

GABA‐mediated changes in excitability of the rat lateral olfactory tract in vitro.

Cain¹,

Simmonds²

1982

The Journal of Physiology

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SUMMARY1. Conditioning stimulation of the lateral olfactory tract (l.o.t,) in the rat olfactory cortex slice evoked a slow depolarization of the terminal regions of the l.o.t. The depolarization lasted about 150 ms and was abolished by the y-aminobutyric acid (GABA) antagonist bicuculline.2. Excitability testing of the terminal regions of the l.o.t. showed an increase in excitability which lasted for about 150 ms following a conditioning stimulus. This increase in excitability was abolished by the calcium antagonist cadmium and by the GABA antagonists bicuculline and penicillin.3. Superfused GABA caused a consistent decrease in the excitability of the terminal regions of the l.o.t. within the cortex but an increase in excitability of the axons within the tract itself. These effects were antagonized by bicuculline. K+ caused similar changes in excitability which were not antagonized by bicuculline.4. The difference between the effects of superfused GABA and the effects of orthodromic conditioning can be explained if a more restricted location of action is assumed for the GABA released by conditioning stimulation. It is suggested that GABA causes a decrease in excitability at its locus of action and that the observed increases in exictability occur in adjacent areas of neuronal membrane.

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“…Lateral excitatory network physiology was performed by placing one suction electrode on the nerve cord rostral to the terminal ganglion to stimulate the LG and for identifying sensory afferents by the primary afferent depolarization that results from an LG spike (Bryan and Krasne, 1977). One or two suction electrodes were placed on peripheral nerves of A6 to evoke afferent volleys (Fig.…”

Section: Methodsmentioning

confidence: 99%

The Retrograde Spread of Synaptic Potentials and Recruitment of Presynaptic Inputs

Antonsen¹,

Herberholz²,

Edwards³

2005

J. Neurosci.

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Lateral excitation is a mechanism for amplifying coordinated input to postsynaptic neurons that has been described recently in several species. Here, we describe how a postsynaptic neuron, the lateral giant (LG) escape command neuron, enhances lateral excitation among its presynaptic mechanosensory afferents in the crayfish tailfan. A lateral excitatory network exists among electrically coupled tailfan primary afferents, mediated through central electrical synapses. EPSPs elicited in LG dendrites as a result of mechanosensory stimulation spread antidromically back through electrical junctions to unstimulated afferents, summate with EPSPs elicited through direct afferentto-afferent connections, and contribute to recruitment of these afferents. Antidromic potentials are larger if the afferent is closer to the initial input on LG dendrites, which could create a spatial filtering mechanism within the network. This pathway also broadens the temporal window over which lateral excitation can occur, because of the delay required for EPSPs to spread through the large LG dendrites. The delay allows subthreshold inputs to the LG to have a priming effect on the lateral excitatory network and lowers the threshold of the network in response to a second, short-latency stimulus. Retrograde communication within neuronal pathways has been described in a number of vertebrate and invertebrate species. A mechanism of antidromic passage of depolarizing current from a neuron to its presynaptic afferents, similar to that described here in an invertebrate, is also present in a vertebrate (fish). This raises the possibility that short-term retrograde modulation of presynaptic elements through electrical junctions may be common.

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Presynaptic inhibition: the mechanism of protection from habituation of the crayfish lateral giant fibre escape response.

Cited by 53 publications

References 44 publications

Adaptive motor control in crayfish

Adaptive motor control in crayfish

GABA‐mediated changes in excitability of the rat lateral olfactory tract in vitro.

The Retrograde Spread of Synaptic Potentials and Recruitment of Presynaptic Inputs

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