“…Two recent reports, described such effect on avian and mammalian neuromuscular preparations: in the avian chick biventer cervicis preparation, the methanolic extract of R. schneideri poison was shown to act presynaptically by irreversibly blocking acetylcholine release; no co-participation of post-synaptic nicotinic receptors on the neuromuscular blockade was observed (Rostelato- Ferreira, Dal Belo, Cruz-Höfling, Hyslop, & Rodrigues-Simioni, 2011). Interestingly, in in vitro mice hemidiaphragm preparations R. schneideri poison extract elicited increases in the acetylcholine release, facilitating neurotransmission by a mechanism that suggests the involvement of the Na + K + ATPase pump system (Rostelato-Ferreira, Dal Belo, Leite, Hyslop, & Rodrigues-Simioni, 2014).…”