Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms

Kaiser, Sergio; Soliakov, L.; Wonnacott, Susan

doi:10.1007/978-3-642-57079-7_8

Cited by 7 publications

(2 citation statements)

References 81 publications

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“…Auch im Striatum wurden Hinweise auf die Existenz zweier Arten von Nikotinrezeptoren auf dopaminergen Neuronen gefunden. Neben a4b2-Rezeptoren scheinen zusätzlich a3b2-Rezeptoren bei der Freisetzung von Dopamin involviert zu sein (Kaiser & Wonnacott, 2000). Möglicherweise sind hier auch noch andere Neurone beteiligt, die nicht dem dopaminergen System, sondern z.B.…”

Section: Acetylcholinrezeptorenunclassified

Nikotin: Molekulare und physiologische Effekte im Zentralnervensystem : ein stereospezifisches Modell zur Analyse der Nikotinperzeption, liking und sensorisch induziertem Craving

Goßler

2009

Schriften Aus Der Fakultät Humanwissenschaften Der Otto-Friedrich-Universität Bamberg

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Section: Acetylcholinrezeptorenunclassified

Nikotin: Molekulare und physiologische Effekte im Zentralnervensystem : ein stereospezifisches Modell zur Analyse der Nikotinperzeption, liking und sensorisch induziertem Craving

Goßler

2009

Schriften Aus Der Fakultät Humanwissenschaften Der Otto-Friedrich-Universität Bamberg

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“…Despite this potential for heterogeneity of nicotinic ACh receptors, their physiological role in the brain is far from clear, with few examples of nicotinic transmission at central synapses ( Role & Berg, 1996 ; Jones et al ., 1999 ). However, the presence of presynaptic nicotinic ACh receptors able to facilitate the release of various transmitters is well documented ( Wonnacott, 1997 ; Kaiser et al ., 2000 ), and a primary role of nicotinic ACh receptors in the brain may be to ‘modify rather than mediate’ synaptic transmission ( Role & Berg, 1996 ).…”

Section: Introductionmentioning

confidence: 99%

Involvement of protein kinase C in the presynaptic nicotinic modulation of [³H]‐dopamine release from rat striatal synaptosomes

Soliakov

Wonnacott

2001

British J Pharmacology

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1 Presynaptic nicotinic ACh receptors modulate transmitter release in the brain. Here we report their interactions with protein kinase C (PKC) with respect to [ 3 H]-dopamine release from rat striatal synaptosomes, monitored by superfusion. 2 Two speci®c PKC inhibitors, Ro 31-8220 (1 mM) and D-erythro-sphingosine (10 mM) signi®cantly reduced (by 51 and 26% respectively) [ 3 H]-dopamine release stimulated by anatoxin-a (AnTx), a potent and selective agonist of nicotinic ACh receptors. The inactive structural analogue of Ro 31-8220, bisindolylmaleimide V (1 mM) had no e ect. 3 Two phorbol esters, PDBu (1 mM) and PMA (1 mM) potentiated AnTx-evoked [ 3 H]-dopamine release by 50 ± 80%. This was Ca 2+ -dependent and prevented by PKC inhibitors. In the absence of nicotinic agonist, phorbol esters enhanced basal release through a PKC-independent mechanism. 4 A 86 Rb + e ux assay of nicotinic ACh receptor function con®rmed that Ro 31-8220 has no nonspeci®c e ect on presynaptic nicotinic ACh receptors. 5 These results suggest that PKC is activated by nicotinic ACh receptor stimulation and mediates a component of AnTx-evoked [ 3 H]-dopamine release. In addition, independent activation of PKC can further amplify the response, o ering a potential mechanism for receptor crosstalk.

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Neuronal Nicotinic Receptors: History, Structure, and Functional Roles

Lindstrom¹

Exploring the Vertebrate Central Cholinergic Nervous System

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Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms

Cited by 7 publications

References 81 publications

Nikotin: Molekulare und physiologische Effekte im Zentralnervensystem : ein stereospezifisches Modell zur Analyse der Nikotinperzeption, liking und sensorisch induziertem Craving

Nikotin: Molekulare und physiologische Effekte im Zentralnervensystem : ein stereospezifisches Modell zur Analyse der Nikotinperzeption, liking und sensorisch induziertem Craving

Involvement of protein kinase C in the presynaptic nicotinic modulation of [³H]‐dopamine release from rat striatal synaptosomes

Neuronal Nicotinic Receptors: History, Structure, and Functional Roles

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Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms

Cited by 7 publications

References 81 publications

Nikotin: Molekulare und physiologische Effekte im Zentralnervensystem : ein stereospezifisches Modell zur Analyse der Nikotinperzeption, liking und sensorisch induziertem Craving

Nikotin: Molekulare und physiologische Effekte im Zentralnervensystem : ein stereospezifisches Modell zur Analyse der Nikotinperzeption, liking und sensorisch induziertem Craving

Involvement of protein kinase C in the presynaptic nicotinic modulation of [3H]‐dopamine release from rat striatal synaptosomes

Neuronal Nicotinic Receptors: History, Structure, and Functional Roles

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Involvement of protein kinase C in the presynaptic nicotinic modulation of [³H]‐dopamine release from rat striatal synaptosomes