Presynaptic regulation of extracellular dopamine levels in the medial prefrontal cortex and striatum during tyrosine depletion

Brodnik, Zachary D.; Double, Manda; Jaskiw, George E.

doi:10.1007/s00213-013-2977-0

Cited by 12 publications

(10 citation statements)

References 81 publications

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“…This is likely associated with a number of other changes observed in the NAc. For example, increases in DAT may translate into lower basal dopamine release in caffeine-exposed rats (Bello et al, 2011;Brodnik et al, 2013;Donovan et al, 1999). Genetic overexpression of DAT on dopamine neurons in the striatum produces decreased basal dopamine levels, as well as behavioral observations similar to our findings, such as increased cocaine-induced locomotion and increased development of cocaine CPP (Donovan et al, 1999;Salahpour et al, 2008).…”

Section: Discussionsupporting

confidence: 85%

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

O’Neill

Levis

Schreiner

et al. 2014

Neuropsychopharmacol

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Caffeine is the most commonly used psychoactive substance, and consumption by adolescents has risen markedly in recent years. We identified the effects of adolescent caffeine consumption on cocaine sensitivity and determined neurobiological changes within the nucleus accumbens (NAc) that may underlie caffeine-induced hypersensitivity to cocaine. Male Sprague-Dawley rats consumed caffeine (0.3 g/l) or water for 28 days during adolescence (postnatal day 28-55; P28-P55) or adulthood (P67-P94). Testing occurred in the absence of caffeine during adulthood (P62-82 or P101-121). Cocaine-induced and quinpirole (D 2 receptor agonist)-induced locomotion was enhanced in rats that consumed caffeine during adolescence. Adolescent consumption of caffeine also enhanced the development of a conditioned place preference at a sub-threshold dose of cocaine (7.5 mg/kg, i.p.). These behavioral changes were not observed in adults consuming caffeine for an equivalent period of time. Sucrose preferences were not altered in rats that consumed caffeine during adolescence, suggesting there are no differences in natural reward. Caffeine consumption during adolescence reduced basal dopamine levels and augmented dopamine release in the NAc in response to cocaine (5 mg/kg, i.p.). Caffeine consumption during adolescence also increased the expression of the dopamine D 2 receptor, dopamine transporter, and adenosine A 1 receptor and decreased adenosine A 2A receptor expression in the NAc. Consumption of caffeine during adulthood increased adenosine A 1 receptor expression in the NAc, but no other protein expression changes were observed. Together these findings suggest that caffeine consumption during adolescence produced changes in the NAc that are evident in adulthood and may contribute to increases in cocaine-mediated behaviors.

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Section: Discussionsupporting

confidence: 85%

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

O’Neill

Levis

Schreiner

et al. 2014

Neuropsychopharmacol

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“…Studies in animals (Palmour et al, 1998;McTavish et al, 1999;Brodnik et al, 2013) and humans (Montgomery et al, 2003;Leyton et al, 2004) have established that this method reduces CSF amine metabolite levels and brain dopamine levels by approximately 30% (Montgomery et al, 2003) for a period of several hours. The AA mixtures were administered double blind, in counterbalanced order.…”

Section: Studymentioning

confidence: 98%

Striatal D1 and D2 signaling differentially predict learning from positive and negative outcomes

et al. 2015

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“…The same depleting AA mixtures have also been shown to inhibit amphetamine-induced manic behavior and DA neurotransmission in humans ( McTavish et al, 1999b , 2001b ; Leyton et al, 2004 ) and rats ( McTavish et al, 1999a , 2001a ; Le Masurier et al, 2004 , 2006 ; Jaskiw et al, 2006 ; Bongiovanni et al, 2008 , 2012 ; Brodnik et al, 2013 ). Together, these preliminary observations suggest that the depletion of Tyr and Phe in the brain by dietary means could have potential as a nutritional supplementary treatment for acute mania.…”

Section: Introductionmentioning

confidence: 98%

A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania

Liebenberg

Jensen

Larsen

et al. 2018

International Journal of Neuropsychopharmacology

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BackgroundCasein glycomacropeptide is a peptide that lacks phenylalanine, tyrosine, and tryptophan. This profile may enable it to deplete phenylalanine, tyrosine, and tryptophan, and subsequently the synthesis of dopamine and serotonin in the brain. Dopamine- and serotonin-depleting amino acid mixtures have shown promise as acute antimanic treatments. In this study, we explore the depleting effects on amino acids, dopamine and serotonin as well as its actions on manic-like and other behavior in rats.MethodsCasein glycomacropeptide and a selection of amino acid mixtures were administered orally at 2, 4, or 8 h or for 1 week chronically. Amino acid and monoamine levels were measured in plasma and brain and behavior was assessed in the amphetamine-hyperlocomotion, forced swim, prepulse inhibition, and elevated plus maze tests.ResultsCasein glycomacropeptide induced a time-dependent reduction in tyrosine, tryptophan, and phenylalanine in brain and plasma which was augmented by supplementing with leucine. Casein glycomacropeptide +leucine reduced dopamine in the frontal cortex and serotonin in the hippocampus, frontal cortex, and striatum after 2 and 4 h. Casein glycomacropeptide+leucine also had antimanic activity in the amphetamine-induced hyperlocomotion test at 2 h after a single acute treatment and after 1 week of chronic treatment.ConclusionsCasein glycomacropeptide-based treatments and a branched-chain amino acid mixture affected total tissue levels of dopamine in the frontal cortex and striatum and serotonin in the frontal cortex, striatum, and hippocampus of rats in a time-dependent fashion and displayed antimanic efficacy in a behavioral assay of mania.

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Presynaptic regulation of extracellular dopamine levels in the medial prefrontal cortex and striatum during tyrosine depletion

Cited by 12 publications

References 81 publications

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Striatal D1 and D2 signaling differentially predict learning from positive and negative outcomes

A Preclinical Study of Casein Glycomacropeptide as a Dietary Intervention for Acute Mania

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