2013
DOI: 10.1016/j.biopsych.2012.11.017
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Presynaptic Striatal Dopamine Dysfunction in People at Ultra-high Risk for Psychosis: Findings in a Second Cohort

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Cited by 217 publications
(169 citation statements)
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“…, elevated dopaminergic activity in the striatum 19 and midbrain 15 , and abnormalities in levels of glutamate 20 and GABA 21 . In general, these abnormalities are qualitatively similar but less severe than those seen in patients with psychotic disorders 5 .…”
mentioning
confidence: 99%
“…, elevated dopaminergic activity in the striatum 19 and midbrain 15 , and abnormalities in levels of glutamate 20 and GABA 21 . In general, these abnormalities are qualitatively similar but less severe than those seen in patients with psychotic disorders 5 .…”
mentioning
confidence: 99%
“…De forma comparativa, hay evidencia sólida de alteraciones en población UHR a varios niveles, entre los que resaltan estudios con tomografía por emisión de positrones, que demostraron un aumento en la síntesis estriatal de dopamina en pacientes con APS comparados a controles (65,66). Otros hallazgos dan fe de cambios estructurales, como volúmenes de materia gris disminuidos a distintos niveles e hiperperfusión en reposo en hipocampo, mesencéfalo y ganglios basales (67-69).…”
Section: Rev Neuropsiquiatr 80 (1) 2017unclassified
“…The HV group was recruited from the same geographic area and had no personal of psychiatric symptoms, or psychotropic medication. Both the CHR and HV groups included subjects who had participated in previous dopamine imaging studies 19,21 where information on immigration status was available. Exclusion criteria for all participants included pregnancy or other contra-indications to PET imaging.…”
Section: Uk Study: Striatal Dopamine Synthesis Capacitymentioning
confidence: 99%
“…The absence of illicit substance use other than cannabis was confirmed by urine drugs screen at the time of PET imaging. 19 or a CTI/Siemens ECAT HR++ 966 tomograph (10 HV; 24 CHR) 21 (Siemens Molecular Imaging). All participants were asked to fast for 12 h before imaging and received carbidopa (150 mg) and entacapone (400 mg) orally 1 h before imaging to ]-DOPA injection with four 60-s frames, three 120-s frames, three 180-s frames, and fifteen 300-s frames).…”
Section: Uk Study: Striatal Dopamine Synthesis Capacitymentioning
confidence: 99%
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