1983
DOI: 10.1111/j.1476-5381.1983.tb08817.x
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Presynaptic α2‐adrenoceptor antagonism by verapamil but not by diltiazem in rabbit hypothalamic slices

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Cited by 46 publications
(18 citation statements)
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“…For instance, verapamil appears to block serotoninergic and alpha 2 -adrenoceptor receptors, while diltiazem do not compete for these receptors. 34,35) Therefore, our data suggest that GABA A receptor and voltage-dependent L-type calcium channel activation are not involved in the psychostimulation induced by pulegone, in contrast to previous results observed following ethanol treatment. 22,23) These experiments evidence that pulegone-induced behavioral alterations are also pharmacologically distinguishable from those induced by classical depressants, despite the similarities among the observed behavioral alterations.…”
Section: Discussioncontrasting
confidence: 56%
“…For instance, verapamil appears to block serotoninergic and alpha 2 -adrenoceptor receptors, while diltiazem do not compete for these receptors. 34,35) Therefore, our data suggest that GABA A receptor and voltage-dependent L-type calcium channel activation are not involved in the psychostimulation induced by pulegone, in contrast to previous results observed following ethanol treatment. 22,23) These experiments evidence that pulegone-induced behavioral alterations are also pharmacologically distinguishable from those induced by classical depressants, despite the similarities among the observed behavioral alterations.…”
Section: Discussioncontrasting
confidence: 56%
“…Neither verapamil nor nimodipine displaced [3HJ-naloxone from its binding sites and therefore they are probably not active at the level of the opioid receptor. Furthermore, while verapamil seems to be able to increase NA release both in brain and peripheral tissues (Galzin & Langer, 1983;Zsoter et al, 1984) and to interact with NA receptors (Nayler et al, 1982;Galzin & Langer, 1983), nimodipine (1Omg kg' i.v.) does not alter the brain NA content or metabolism and at a concentration of IO-' M does not interact in vitro with the actions ofNA (Towart et al, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…Verapamil (10-4 M), in contrast to diltiazem, increased the 3H-overflow from transmurally stimulated arteries less than from non-stimulated vessels. If verapamil induces the release of NA by blocking presynaptic a2-adrenoceptors, as suggested by Galzin & Langer (1983), the opposite effect would be expected, that is a greater rather than a reduced release of 3H on stimulation of sympathetic nerves.…”
Section: Discussionmentioning
confidence: 99%