Pretargeted Radiopharmaceutical Therapy

Molecular Imaging of Monoamine Oxidase A Expression in Highly Aggressive Prostate Cancer: Synthesis and Preclinical Evaluation of Positron Emission Tomography Tracers

“…11 C and 18 amino acids, peptides, and small biomolecules, have gained much attention for PET imaging in various disease conditions. 8 Carbon-11 allows isotopic labeling, and its radiochemistry has been well studied in recent decades, but its short half-life (20.4 min) limits its use. In this context, fluorine-18 is more commonly used in radiolabeling due to its longer half-life (110 min), which provides advantages in radiosynthesis steps and for transporting it to other institutes.…”

“…In this context, fluorine-18 is more commonly used in radiolabeling due to its longer half-life (110 min), which provides advantages in radiosynthesis steps and for transporting it to other institutes. 8 Numerous studies have demonstrated that malignant tumors can be detected with high sensitivity and specificity using PET imaging. F]fluciclovine PET have been shown to detect nodal and osseous disease at higher rates compared to FDG-PET but offer no additional benefit in detecting prostate disease, especially in primary staging.…”