Preterm birth and genitourinary tract infections: assessing gene–environment interaction

Elías, Darío; Giménez, Lucas Gabriel; Poletta, Fernando A.; Campaña, Hebe; Gili, Juan Antonio; Ratowiecki, Julia; Pawluk, Mariela Soledad; Rittler, Mónica; Santos, Maria Rita de Morais Chaves; Uranga, Rocio; Heisecke, Silvina; Cosentino, Viviana; Saleme, César; Gadow, Enrique C.; Krupitzki, Hugo; Camelo, Jorge Santiago López

doi:10.1038/s41390-020-01200-z

Cited by 12 publications

(7 citation statements)

References 39 publications

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“…Nevertheless, since minorities are more likely to reside in areas contaminated with environmental pollutants [149][150][151][152], gene-environment interactions could be a plausible contributor to the racial and geographic disparity of PTB. This line of inquiry is supported by a recent study that examined the presence of specific single-nucleotide polymorphisms in the mother or fetus and the risk of PTB in association with maternal infections [171]. They found a significant association with six different SNPs, PTB, and a recent maternal history of a vaginal infection or urinary tract infection.…”

Section: Premature Birthmentioning

confidence: 81%

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health

Rumph

Stephens

Martin

et al. 2022

IJERPH

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Over the years, industrial accidents and military actions have led to unintentional, large-scale, high-dose human exposure to environmental contaminants with endocrine-disrupting action. These historical events, in addition to laboratory studies, suggest that exposure to toxicants such as dioxins and polychlorinated biphenyls negatively impact the reproductive system and likely influence the development of gynecologic diseases. Although high-level exposure to a single toxicant is rare, humans living in industrialized countries are continuously exposed to a complex mixture of manmade and naturally produced endocrine disruptors, including persistent organic pollutants and heavy metals. Since minorities are more likely to live in areas with known environmental contamination; herein, we conducted a literature review to identify potential associations between toxicant exposure and racial disparities in women’s health. Evidence within the literature suggests that the body burden of environmental contaminants, especially in combination with inherent genetic variations, likely contributes to previously observed racial disparities in women’s health conditions such as breast cancer, endometriosis, polycystic ovarian syndrome, uterine fibroids, and premature birth.

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Section: Premature Birthmentioning

confidence: 81%

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health

Rumph

Stephens

Martin

et al. 2022

IJERPH

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“…On the contrary, as it was mentioned above, the deactivation of the device resulted in a recurrence of urinary symptoms, such as urgency and urinary retention, complicated by UTIs. In turn, UTIs put pregnancy at risk for preterm labour [ 25 , 26 ]. The correlation between neuromodulation and uterine contractile activity seems to be questionable.…”

Section: Discussionmentioning

confidence: 99%

Sacral Neuromodulation in Pregnant Women—A Case Report and Literature Review

Szymański

Słabuszewska-Jóźwiak

Jakiel

2022

IJERPH

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Millions of women around the world suffer from an overactive bladder and urinary retention. A significant number of them are of reproductive age. For 25 years, SNM has been an effective therapy for treatment-resistant hyperactive bladder and idiopathic urinary retention. The paper presents a case of a 35-year-old pregnant woman with an overactive bladder resistant to pharmacological treatment, who responded positively to sacral neuromodulation. The patient decided against deactivating the neuromodulator and, after an uneventful course of pregnancy, she gave birth by a caesarean section to a healthy female infant. The use of SNM in pregnant patients remains a constant clinical challenge. The current literature was reviewed, but published studies do not provide a clear answer. Further studies with a long follow-up period are necessary to determine more accurately the effects of SNM therapy on the fetus and the course of pregnancy. Currently, it is recommended to deactivate SNM during pregnancy. However, it seems that an individual approach to the patient with information on the risks and benefits of continuing or discontinuing therapy should be the current procedure.

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“…McClure and Goldenberg 49 considered the presence of abnormal vaginal flora as a simple marker of other risk factors. Results from other studies suggest interactions between genitourinary tract infections and genes linked to infectious/inflammatory/hormonal regulation processes that increase the PTB risk 50,51 .…”

Section: Vaginal and Urinary Tract Infectionsmentioning

confidence: 96%

Diseases during pregnancy in a large unselected South American sample

Santos

Campaña

Heisecke

et al. 2022

Rev. bras. epidemiol.

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Objective: Our aim was to describe the prevalence of diseases during pregnancy and the association between fetal exposure to the most frequent maternal diseases and the risk of preterm (PTB) and/or small for gestational age (SGA) newborns in an unselected sample of women who gave birth in South American countries. Methods: We conducted a descriptive, cross-sectional study including 56,232 mothers of non-malformed infants born between 2002 and 2016, using data from the Latin American Collaborative Study of Congenital Malformations (ECLAMC). Diseases with higher- than-expected PTB/SGA frequencies were identified. Odds ratios of confounding variables for diseases and birth outcomes were calculated with a multivariable logistic regression. Results: Of the 14 most reported diseases, hypertension, genitourinary infection, epilepsy, hypothyroidism, diabetes, and HIV/AIDS showed higher PTB and/or SGA frequencies. Advanced and low maternal age, previous fetal loss, low socioeconomic level, and African-American ancestry were associated with PTB, while advanced maternal age, primigravidity, previous fetal loss, low socioeconomic level, and African-American ancestry were associated with SGA. After adjusting for the associated variables, the identified illnesses maintained their association with PTB and all, except epilepsy, with SGA. Conclusion: The description of an unselected population of mothers allowed identifying the most frequent diseases occurring during gestation and their impact on pregnancy outcomes. Six diseases were associated with PTB and two with SGA newborns. To the best of our knowledge, there are no similar reports about women not intentionally selected by specific diseases during pregnancy in South American populations.

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Preterm birth and genitourinary tract infections: assessing gene–environment interaction

Cited by 12 publications

References 39 publications

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health

Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health

Sacral Neuromodulation in Pregnant Women—A Case Report and Literature Review

Diseases during pregnancy in a large unselected South American sample

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