Preterm Birth with Childhood Asthma: The Role of Degree of Prematurity and Asthma Definitions

He, Huan; Butz, Arlene; Keet, Corinne A.; Minkovitz, Cynthia S.; Hong, Xiumei; Caruso, Deanna; Pearson, Colleen; Cohen, Robyn T.; Wills‐Karp, Marsha; Zuckerman, Barry; Hughes, Mary Elizabeth; Wang, Xiaobin

doi:10.1164/rccm.201503-0522le

Cited by 30 publications

(25 citation statements)

References 11 publications

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“…Numerous studies have shown that individuals born prematurely can have lifelong health problems in multiple organs or systems, including asthma and metabolic disorders, causing tremendous strain on families and the medical system and resulting in enormous annual medical costs worldwide. 32,33 In the present study, we found an increased PTB risk of 9% associated with an increase in PM 1 concentration of 10 μg/m 3 over the entire pregnancy. Compared with less polluted areas (PM 1 <38.4 μg/m 3 ), an increased PTB risk of 36% was found in areas with higher levels of air pollution (PM 1 >52.7 μg/m 3 ) in China.…”

Section: Hazard Ratiosupporting

confidence: 53%

Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China

Wang¹,

Lee

et al. 2018

JAMA Pediatr

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IMPORTANCE Airborne particulate matter pollution has been associated with preterm birth (PTB) in some studies. However, most of these studies assessed only populations living near monitoring stations, and the association of airborne particulate matter having a median diameter of 1 μm or less (PM 1) with PTB has not been studied. OBJECTIVE To evaluate whether PM 1 concentrations are associated with the risk of PTB. DESIGN, SETTING, AND PARTICIPANTS This national cohort study used National Free Preconception Health Examination Project data collected in 324 of 344 prefecture-level cities from 30 provinces of mainland China. In total, 1 300 342 healthy singleton pregnancies were included from women who were in labor from

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Section: Hazard Ratiosupporting

confidence: 53%

Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China

Wang¹,

Lee

et al. 2018

JAMA Pediatr

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“…Recent evidence demonstrates that the degree of prematurity has a dose effect in assessing the risk of developing asthma. 7 We have also found that there is relative dose response of prematurity in the secretion of airway Th2 cytokines during HRV infection. 13 Specifically, the group of children born <32 weeks gestation had the strongest Th2 response to HRV, with gradual decrease in individuals born at 32–37 weeks gestation and Th2 response was even lower in full term children with HRV.…”

Section: Resultsmentioning

confidence: 61%

“…Prematurity is associated with chronic lung disease (CLD) characterized by hypoxemia due to abnormal alveolarization leading to simplified gas-exchange units. 5 Interestingly, in addition to CLD, premature birth is increasingly recognized as a major risk factor for the development of the asthmatic condition, 6 , 7 although the underlying mechanisms of this association are presently unknown. It is also well-established that premature children are at high risk of developing severe lower respiratory tract infections caused by paramyxoviruses such as Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (HMPV), which exacerbate underlying hypoxemia and CLD.…”

Section: Introductionmentioning

confidence: 99%

Phenotypical characterization of human rhinovirus infections in severely premature children

Pérez

Kurdi

Megalaa

et al. 2018

Pediatrics & Neonatology

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BackgroundHuman Rhinovirus (HRV) has been identified as the most common cause of acute respiratory infections and hospitalizations in premature children. It is unclear if premature children are more susceptible to HRV due to their decreased pulmonary reserve or because they have enhanced lower airway reactivity to HRV.MethodsWe conducted a retrospective analysis of the clinical respiratory presentation of all PCR-confirmed HRV infections in full-term and premature children aged ≤3 years in our institution. Standardized respiratory distress scores were developed to examine lower airway obstruction (i.e., wheezing, hyperinflation, and sub-costal retractions) along with markers of decreased pulmonary reserve (hypoxemia and tachypnea) in young children with HRV infections. Demographic and clinical variables were obtained from reviewing electronic medical records (EMR).ResultsThis study included a total of 205 children; 71% of these children were born full-term (>37 weeks gestation), 10% preterm (32–37 weeks) and 19% severely premature (<32 weeks). Our results demonstrated that: 1) HRV infections in the first 3 years of life were associated with higher overall respiratory distress scores in severely premature children relative to children born preterm or full-term; 2) HRV-infected severely premature children ≤3 years old were more likely to have lower airway obstruction than HRV-infected children born preterm or full-term; and 3) other clinical signs of respiratory distress such as tachypnea and hypoxemia were not more common in severely premature than in preterm and full-term children during an HRV infection.ConclusionsOur results indicate that HRV infections in severely premature children are associated with lower airway obstruction rather than hypoxemia or tachypnea. The latter suggests that enhanced airway reactivity is the underlying mechanism for the increased susceptibility to HRV in severely premature children. Longitudinal studies are needed to understand why premature babies develop airway hyper-reactivity to HRV and the long-term effects of early HRV infection in this population.

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“…11 Both urban and poor areas tend to have higher densities of major roadways and to be closer to stationary sources of air pollution, such as power plants and manufacturing facilities, and thus have higher levels of pollutants associated with asthma morbidity, such as particulate matter, nitric oxides, and ozone. Additional environmental factors that may contribute to asthma morbidity in poor and urban areas include exposure to secondhand smoke 12 and other sources of indoor pollution, 13 prematurity, 14 and social stress. 15 Differences in health care quality, adherence to medications, and care access patterns could also explain some of the neighborhood disparities found here.…”

Section: Discussionmentioning

confidence: 99%

Urban residence, neighborhood poverty, race/ethnicity, and asthma morbidity among children on Medicaid

Keet

Matsui

McCormack

et al. 2017

Journal of Allergy and Clinical Immunology

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145

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Preterm Birth with Childhood Asthma: The Role of Degree of Prematurity and Asthma Definitions

Cited by 30 publications

References 11 publications

Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China

Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China

Phenotypical characterization of human rhinovirus infections in severely premature children

Urban residence, neighborhood poverty, race/ethnicity, and asthma morbidity among children on Medicaid

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