Preterm Labor

Germaín, A; Carvajal, Jorge; Sánchez, Marta; Valenzuela, Guillermo J.; Tsunekawa, Harumi; Chuaqui, B

doi:10.1097/00006250-199908000-00025

Cited by 3 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the context of the role of GPR18 as a receptor for the SPM RvD2, the expression of GPR18 on the vascular-associated cell types is of physiological significance, because appropriate vascular functioning is critical to maintain maternal-fetal health and prevent negative perinatal outcomes. Dysfunctions in placental vasculature increase risk for intrauterine growth restriction, preterm delivery, and pre-eclampsia [21,22,23,24]. While some studies aimed at finding molecular biomarkers for these complications, others focus on lipids.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities

Ulu

Sahoo

Yuil‐Valdes

et al. 2019

IJMS

View full text Add to dashboard Cite

Omega-3 fatty acids are important to pregnancy and neonatal development and health. One mechanism by which omega-3 fatty acids exert their protective effects is through serving as substrates for the generation of specialized pro-resolving lipid mediators (SPM) that potently limit and resolve inflammatory processes. We recently identified that SPM levels are increased in maternal blood at delivery as compared to umbilical cord blood, suggesting the placenta as a potential site of action for maternal SPM. To explore this hypothesis, we obtained human placental samples and stained for the SPM resolvin D2 (RvD2) receptor GPR18 via immunohistochemistry. In so doing, we identified GPR18 expression in placental vascular smooth muscle and extravillous trophoblasts of the placental tissues. Using in vitro culturing, we confirmed expression of GPR18 in these cell types and further identified that stimulation with RvD2 led to significantly altered responsiveness (cytoskeletal changes and pro-inflammatory cytokine production) to lipopolysaccharide inflammatory stimulation in human umbilical artery smooth muscle cells and placental trophoblasts. Taken together, these findings establish a role for SPM actions in human placental tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities

Ulu

Sahoo

Yuil‐Valdes

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…This suggests that in PET cases, HPV oncoproteins affecting cell function likely occur in the placenta if high-risk HPV DNA is present [25,32]. In trophoblast cultures, the introduction of HPV influenced the resulting trophoblast phenotypes, which would impair implantation and placental maintenance that underpin PET [8,20,[33][34][35]; this was also observed in a study that only introduced E6 and E7 without the whole HPV genome [20].…”

Section: Discussionmentioning

confidence: 80%

“…In the FGR, diabetic, and HPV-positive control cohorts (Figure 4), HPV 18 was present in 67% (n = 6/9), 50% (n = 3/6), and 63% (n = 5/8) of cases with an HPV type identified, respectively. In all cohorts, the next most frequent HPV type was 16, followed by other high-risk types 33,35,39,45,52, and 66. Low-risk HPV types (42,55) and types of unclassified risk (26, 40, 53, 61, and 89) were also found amongst the cohorts.…”

Section: Hpv Types In the Pet Placentamentioning

confidence: 98%

Human Papillomavirus E6/E7 Expression in Preeclampsia-Affected Placentae

et al. 2020

View full text Add to dashboard Cite

Whether HPV is causative of pregnancy complications is uncertain. E6 and E7 affect functions underling preeclampsia (PET) in cultured trophoblasts, but whether E6 and E7 is produced in the placenta is uncertain. Here, we investigated whether E6/E7 was expressed in the placentae from pregnancies with PET, other pregnancy complications (fetal growth restriction (FGR) and diabetes mellitus), and uncomplicated pregnancies. Placental tissues collected from two geographical locations were subjected to RNAscope analyses of high- and low- risk E6/E7, and individual HPV types identified using an HPV array. High-risk E6/E7 expression was increased in both PET cohorts, (81% and 86% of patients positive for high-risk HPV DNA compared to 13% of control patients). Various HPV types were identified. Although HPV 18 was the most frequent in all cohorts, the majority of individuals had multiple HPV types (55% of the PET compared to 25% of the control cohort). Further evidence that E6 and E7 is present early when placental pathology underlying preeclampsia is established, is provided with the finding of high-risk E6/E7 in the first-trimester placenta anchoring trophoblast. In conclusion, E6/E7 expression and multiple HPV types were frequent in placentae from preeclampsia-complicated pregnancies.

show abstract

The Association between Dyslipidemia and Preterm Birth: A Prospective Cohort Study in The North of Iran

Sharami

Gholipour

Milani

et al. 2020

EMIDDT

View full text Add to dashboard Cite

Background: Dyslipidemia is recognized as an important factor in the incidence of Preterm Birth (PTB). The early diagnosis of factors affecting PTB is important in the reduction of maternalneonatal complications; therefore, we aimed to evaluate the association between dyslipidemia and PTB in women from the Guilan province of Iran. Method: The current investigation was a prospective cohort study on 378 pregnant women in Rasht city (Guilan province), during 2018-2019. Samples were randomly selected among pregnant women who referred to Al-Zahra hospital. Association of the lipid profiles: Total Cholesterol (TC), High- Density Lipoprotein (HDLC), Low-Density Lipoprotein (LDLC), and Triglycerides (TG) with PTB was assessed using the Chi-square, Fisher tests and logistic regression analysis. Results: Our findings showed that of the evaluated lipid profiles, TG and TC had the highest predictive power with AUC =0.833 (95٪, CI: 0.736-0.930) and 0.772 (95%, CI: 0.676-0.867), respectively; also, their sensitivity and specificity were 83.3%, 70.2% and 83.3%, 66.1%, respectively. Moreover, abnormal LDL concentrations increase the risk of PTB by two folds (P < 0.05). Conclusion: It seems that by controlling the lipid profiles of pregnant women, the risk of PTB could be reduced.

show abstract

Preterm Labor

Cited by 3 publications

References 14 publications

Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities

Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities

Human Papillomavirus E6/E7 Expression in Preeclampsia-Affected Placentae

The Association between Dyslipidemia and Preterm Birth: A Prospective Cohort Study in The North of Iran

Contact Info

Product

Resources

About