Preterm Labor, a Syndrome Attributed to the Combination of External and Internal Factors

Liu, Yuanyuan

doi:10.1097/fm9.0000000000000136

Cited by 4 publications

(3 citation statements)

References 143 publications

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“…We also did not propose a specific mechanism for HIF-1a regulation of TREK1. Mammalian microRNAs (miRNA/miR) play especially powerful roles in smooth muscle cells (55). Hypoxia induces further downregulation of miR-124 (56), and Bucharest et al (57) revealed an inverse correlation between miR-124 and TREK1 expression in neurons.…”

Section: Discussionmentioning

confidence: 99%

High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy

Fei

et al. 2023

Front. Endocrinol.

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BackgroundThe incidence of gestational diabetes mellitus (GDM) is increasing worldwide. GDM patients have a significantly higher rate of cesarean section and postpartum hemorrhage, suggesting changes in uterine contractility. TWIK-1-related potassium channel (TREK1) expressed in the pregnant uterus and its role in uterine contraction. In this study, we examined the expression of HIF-1α and TREK1 proteins in GDM uterine and investigated whether high glucose levels are involved in the regulation of human uterine smooth muscle cells (HUSMCs) contraction through TREK1, and verified the role of HIF-1α in this process.MethodsCompared the uterine contractility between GDM and normal patients undergoing elective lower segment cesarean section. The HUSMCs were divided into normal glucose group, high glucose group, normal glucose with CoCl2 group, CoCl2 with echinomycin/L-Methionine group, and high glucose with echinomycin/L-Methionine group; Compare the cell contractility of each group. Compared the expression of hypoxia-inducible factor-1α (HIF-1α) and TREK1 protein in each group.ResultsThe contractility of human uterine strips induced by both KCl and oxytocin was significantly lower in patients with GDM compared with that in normal individuals, with increased TREK1 and HIF-1α protein expression. The contractility of cultured HUSMCs was significantly decreased under high glucose levels, which was consistent with increased expression of HIF-1α and TREK1 proteins. The contractility of HUSMCs was decreased when hypoxia was induced by CoCl2 and increased when hypoxia was inhibited by echinomycin. The TREK1 inhibitor L-methionine also recovered the decreased contractility of HUSMCs under high glucose levels or hypoxia.DiscussionThe high glucose levels decreased the contractility of the myometrium, and increased expression of HIF-1a and TREK1 proteins play a role in changes in uterus contractility.

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Section: Discussionmentioning

confidence: 99%

High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy

Fei

et al. 2023

Front. Endocrinol.

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“…Although some methods show promise, they have not been implemented on a large scale. 7 Recent advances in high-throughput technologies have led to the use of the transcriptome as an effective tool for predicting health outcomes. 8 Transcriptomic signatures change in response to altered pathological conditions in vivo; the identification and assessment of these signatures may therefore help determine the biological status of various tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, various novel methods for PTB prediction have been studied in recent years; these include the assessment of genetic loci, circulatory protein biomarkers, the vaginal microbiome, and placental elasticity, among others. Although some methods show promise, they have not been implemented on a large scale 7 …”

Section: Introductionmentioning

confidence: 99%

Predicting the Risk of Preterm Birth Throughout Pregnancy Based on a Novel Transcriptomic Signature

Ran,

Huang,

Yin

et al. 2023

Maternal Fetal Med

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Objective This study focused on the prediction of preterm birth (PTB). It aimed to identify the transcriptomic signature essential for the occurrence of PTB and evaluate its predictive value in early, mid, and late pregnancy and in women with threatened preterm labor (TPTL). Methods Blood transcriptome data of pregnant women were obtained from the Gene Expression Omnibus database. The activity of biological signatures was assessed using gene set enrichment analysis and single-sample gene set enrichment analysis. The correlation among molecules in the interleukin 6 (IL6) signature and between IL6 signaling activity and the gestational week of delivery and latent period were evaluated by Pearson correlation analysis. The effects of molecules associated with the IL6 signature were fitted using logistic regression analysis; the predictive value of both the IL6 signature and IL6 alone were evaluated using receiver operating characteristic curves and pregnancy maintenance probability was assessed using Kaplan-Meier analysis. Differential analysis was performed using the DEseq2 and limma algorithms. Results Circulatory IL6 signaling activity increased significantly in cases with preterm labor than in those with term pregnancies (normalized enrichment score (NES) = 1.857, P = 0.001). The IL6 signature (on which IL6 signaling is based) was subsequently considered as the candidate biomarker for PTB. The area under the curve (AUC) values for PTB prediction (using the IL6 signature) in early, mid, and late pregnancy were 0.810, 0.695, and 0.779, respectively; these values were considerably higher than those for IL6 alone. In addition, the pregnancy curves of women with abnormal IL6 signature differed significantly from those with normal signature. In pregnant women who eventually had preterm deliveries, circulatory IL6 signaling activity was lower in early pregnancy (NES = −1.420, P = 0.031) and higher than normal in mid (NES = 1.671, P = 0.002) and late pregnancy (NES = 2.350, P < 0.001). In women with TPTL, the AUC values for PTB prediction (or PTB within 7 days and 48 hours) using the IL6 signature were 0.761, 0.829, and 0.836, respectively; the up-regulation of IL6 signaling activity and its correlation with the gestational week of delivery (r = −0.260, P = 0.001) and latency period (r = −0.203, P = 0.012) were more significant than in other women. Conclusion Our findings suggest that the IL6 signature may predict PTB, even in early pregnancy (although the predictive power is relatively weak in mid pregnancy) and is particularly effective in symptomatic women. These findings may contribute to the development of an effective predictive and monitoring system for PTB, thereby reducing maternal and fetal risk.

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Effects of Pregnancy-Onset Asthma on Perinatal Outcomes: A Retrospective Cohort Study

Gu,

Li,

Ding

et al. 2024

The Journal of Allergy and Clinical Immunology: In Practice

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Preterm Labor, a Syndrome Attributed to the Combination of External and Internal Factors

Cited by 4 publications

References 143 publications

High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy

High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy

Predicting the Risk of Preterm Birth Throughout Pregnancy Based on a Novel Transcriptomic Signature

Effects of Pregnancy-Onset Asthma on Perinatal Outcomes: A Retrospective Cohort Study

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