Preterm Labor and Birth Management: Recommendations from the European Association of Perinatal Medicine

Prediction of preterm delivery in symptomatic women using PAMG‐1, fetal fibronectin and phIGFBP‐1 tests: systematic review and meta‐analysis

“…In conclusion, even though all three biomarker tests had similar NPV and LR–, the PAMG‐1 test had the highest PPV and LR+ across all risk stratification groups ( P < 0.05). As such, our review supports the conclusions of the European Association of Perinatal Medicine guidelines, that the PAMG‐1 test is the most accurate one to be used in women with a CL between 15 and 30 mm.…”

“…As the pretest probability of sPTB ≤ 7 days varied significantly between the publications (0.9% to 52%), the predictive values for one population with a certain pretest probability may not apply to another. The pretest probabilities for sPTB ≤ 7 days can vary among populations owing to country‐ or center‐specific algorithms for PTL diagnosis that call for the use of a biomarker test only with an equivocal diagnosis, such as CL between 15 and 30 mm or those who present with any symptom of PTL and minimal cervical dilatation. While our conclusions on the performance of fFN and phIGFBP‐1 are consistent with those of previous systematic reviews, our work includes several studies published since these reviews were carried out.…”

Good clinical practice advice: Antenatal corticosteroids for fetal lung maturation

“…They should not be administered if there is no a substantiated clinical suspicion of preterm delivery in the next 2–7 days. In women with symptoms of preterm labor, cervical length and fibronectin/PAMG1 measurements should be considered to prevent unnecessary hospitalization and use of tocolytic drugs and/or antenatal steroids …”

“…In women with symptoms of preterm labor, cervical length and fibronectin/PAMG1 measurements should be considered to prevent unnecessary hospitalization and use of tocolytic drugs and/ or antenatal steroids. 14…”

Good clinical practice advice: Prediction of preterm labor and preterm premature rupture of membranes

“…Many maternal behaviors influence the risk of PTB, such as tobacco use, alcohol, and illicit drug abuse. Other factors are those related to nutritional habits, such as high intake of sugar‐sweetened drinks and modern Western diet, which increases the risk of PTB, whereas other nutritional factors are associated with a decreased risk, such as intake of fish liver oil, probiotic milk, garlic, and other leek products. Other factors related to an increased risk of PTB are inadequate maternal body mass index (obesity and underweight), unemployment, chronic stress, catastrophic event, life events, and physical inactivity.…”