2023
DOI: 10.1038/s41372-023-01692-7
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Preterm lung and brain responses to mechanical ventilation and corticosteroids

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Cited by 13 publications
(4 citation statements)
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“…Though the median (IQR) cumulative dose used in this study for BPD alone or combined BPD and non-BPD indications is within the published acceptable limits, an increment in cumulative dose exposure without concurrent decrease in the BPD rate raises concerns for possible unwarranted use. 25,26 We believe that (i) centerspecific guidelines for using PNS for BPD and non-BPD indications 27 ; (ii) order sets to influence providers prescribing practices that standardize initiation, duration, and dose consistent with established regimens; (iii) standardizing PNS weaning when used for suspected adrenal insufficiency 22 might address unwarranted variation in PNS use.…”
Section: Discussionmentioning
confidence: 99%
“…Though the median (IQR) cumulative dose used in this study for BPD alone or combined BPD and non-BPD indications is within the published acceptable limits, an increment in cumulative dose exposure without concurrent decrease in the BPD rate raises concerns for possible unwarranted use. 25,26 We believe that (i) centerspecific guidelines for using PNS for BPD and non-BPD indications 27 ; (ii) order sets to influence providers prescribing practices that standardize initiation, duration, and dose consistent with established regimens; (iii) standardizing PNS weaning when used for suspected adrenal insufficiency 22 might address unwarranted variation in PNS use.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, after dexamethasone administration, hBD-2 mRNA expression can be downregulated by dexamethasone whereas hBD-1 synthesis is induced [ 70 ]. This is of particular interest, as use of postnatal corticosteroids could play a role in preventing and treating BPD [ 182 ].…”
Section: Antimicrobial Peptides and Interactions With The Hostmentioning
confidence: 99%
“…The current therapy is limited to a few drugs, such as caffeine and vitamin A, or corticosteroids like dexamethasone. However, this pharmacological approach has been controversially discussed, since on the one hand it has been shown to be associated with neurodevelopmental complications [ 9 , 10 ], whereas on the other hand, a low-dose treatment of high-risk infants turned out to have a positive benefit vs danger relation [ 11 , 12 ]. Nevertheless, these drugs failed to address all aspects of the disease, including the impaired alveolarization and the inflammation.…”
Section: Introductionmentioning
confidence: 99%