Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality

Reikvam, Håkon; Bruserud, Prof. Øystein; Hatfield, Kimberley Joanne

doi:10.1016/j.jtct.2023.03.020

Cited by 6 publications

(6 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stearidonate has been found to be altered in many metabolomics studies. For example, metabolomics profiling of patients with excessive fluid retention, inflammation and acute graft vs. host rejection revealed an alteration in stearidonate (18:4n-3) ( 31 ). Exposure to dioxin, which is known to increase the risk of cardiovascular diseases and hypertension, also lead to increased stearidonate in mice liver ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with our results, a positive association between hexadecadienoate and systolic and diastolic blood pressure has reported in Chinese adults ( 41 ). Moreover, a study investigating the metabolomic profile in patients with chronic thromboembolic pulmonary hypertension showed higher hexadecadienoate levels in those patients compared to controls ( 31 ). Hexadecadienoate (16:2n6) was also listed among the metabolites differentiating insulin-sensitive from insulin-resistant lean/overweight subjects ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolomic profiling reveals key metabolites associated with hypertension progression

Al Ashmar,

Anwardeen,

Anlar

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

IntroductionPre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. If left uncontrolled, pre-hypertension can progress to hypertension, thereby increasing the risk of serious complications such as heart disease, stroke, kidney damage, and others.ObjectiveThe precise mechanisms driving the progression of hypertension remain unknown. Thus, identifying the metabolic changes associated with this condition can provide valuable insights into potential markers or pathways implicated in the development of hypertension.MethodsIn this study, we utilized untargeted metabolomics profiling, which examines over 1,000 metabolites to identify novel metabolites contributing to the progression from pre-hypertension to hypertension. Data were collected from 323 participants through Qatar Biobank.ResultsBy comparing metabolic profiles between pre-hypertensive, hypertensive and normotensive individuals, six metabolites including stearidonate, hexadecadienoate, N6-carbamoylthreonyladenosine, 9 and 13-S-hydroxyoctadecadienoic acid (HODE), 2,3-dihydroxy-5-methylthio- 4-pentenoate (DMTPA), and linolenate were found to be associated with increased risk of hypertension, in both discovery and validation cohorts. Moreover, these metabolites showed a significant diagnostic performance with area under curve >0.7.ConclusionThese findings suggest possible biomarkers that can predict the risk of progression from pre-hypertension to hypertension. This will aid in early detection, diagnosis, and management of this disease as well as its associated complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling reveals key metabolites associated with hypertension progression

Al Ashmar,

Anwardeen,

Anlar

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…These scales, in addition to remaining reliable, validated tools for predicting patient outcomes, might also be helpful in individualized, risk-adapted initial treatment decisions and predicting outcomes for appropriate of treatment response. The final section describes the challenges underlying metabolomics-based experiments and discusses the potential pitfalls of the analytical process, including study design and sample collection (Table I [18,19,[21][22][23][24][25][26][27][28]).…”

Section: Metabolomics As a Biomarker Of Prognosismentioning

confidence: 99%

“…Findings indicate that metabolites are essential regulators of vascular, renal, endothelial, and gastrointestinal cell function, as well as the function of various immune system cells [53,54]. A recently published study by Reikvam et al [24] indicates the potential role of assessing the metabolite profile before a planned allo-SCT procedure. They compared the serum metabolite profile of patients before myeloablative conditioning according to three transplant-related mortality (TRM) complications: 1) acute graft-versus-host disease (aGvHD); 2) extensive fluid overload (FO); and 3) pretransplant inflammation (pTI).…”

Section: Metabolomics As a Diagnostic Biomarkermentioning

confidence: 99%

“…Moreover, T-cells express adenosine receptors, and adenosine plays a crucial role in regulating the initial phases of T-cell activation. Furthermore, Reikvam et al [24] identified a group of metabolites most related to the occurrence of these complications. Given the high risk of death during and after bone marrow transplantation, metabolite profile analysis appears to be a promising new tool to facilitate clinical decision-making before the allo-SCT procedure.…”

Section: Metabolomics As a Diagnostic Biomarkermentioning

confidence: 99%

See 1 more Smart Citation

Metabolic profile analysis in hematological malignancies

Halicki,

Ciesluk,

Piszcz

2024

Acta Haematol Pol.

View full text Add to dashboard Cite

Metabolomics, an emerging discipline, analyzes the totality of metabolites in cells, tissues, and fluids, providing real--time insights into the metabolic state of an organism. Recent advances in technology and databases have driven research focused primarily on the pathophysiology of solid tumors. However, metabolomics is also gaining importance in hematopoietic neoplasms, particularly acute myeloid leukemia and multiple myeloma. This review discusses potential novel biomarkers for diagnosis, risk assessment, and treatment response in hematological cancers that offer promising prospects for personalized therapies.

show abstract

Posttransplant complications: molecular mechanisms and therapeutic interventions

Liu,

Shen,

Yan

et al. 2024

MedComm

View full text Add to dashboard Cite

Posttransplantation complications pose a major challenge to the long‐term survival and quality of life of organ transplant recipients. These complications encompass immune‐mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular mechanisms underlying posttransplantation complications involve a complex interplay of immunological, metabolic, and oncogenic processes, including innate and adaptive immune activation, immunosuppressant side effects, and viral reactivation. Here, we provide a comprehensive overview of the clinical features, risk factors, and molecular mechanisms of major posttransplantation complications. We systematically summarize the current understanding of the immunological basis of allograft rejection and graft‐versus‐host disease, the metabolic dysregulation associated with immunosuppressive agents, and the role of oncogenic viruses in posttransplantation malignancies. Furthermore, we discuss potential prevention and intervention strategies based on these mechanistic insights, highlighting the importance of optimizing immunosuppressive regimens, enhancing infection prophylaxis, and implementing targeted therapies. We also emphasize the need for future research to develop individualized complication control strategies under the guidance of precision medicine, ultimately improving the prognosis and quality of life of transplant recipients.

show abstract

Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality

Cited by 6 publications

References 77 publications

Metabolomic profiling reveals key metabolites associated with hypertension progression

Metabolomic profiling reveals key metabolites associated with hypertension progression

Metabolic profile analysis in hematological malignancies

Posttransplant complications: molecular mechanisms and therapeutic interventions

Contact Info

Product

Resources

About