Pretreatment attrition and treatment initiation delay among rifampicin-resistant tuberculosis patients in Lagos, Nigeria: a retrospective cohort study

Adejumo, Olusola Adedeji; Daniel, Olusoji; Adepoju, Victor Abiola; Onoh, Moses O; Sokoya, Olusola D; Abdur-Razzaq, Hussein; Moronfolu, Olanike; Oyadotun, Omolara M; Olusola-Faleye, Bolanle

doi:10.1093/trstmh/trac054

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…[9] Pasien TBC RO yang baru didiagnosis juga berhubungan signifikan dengan penundaan pengobatan yang lebih lama (delay treatment) daripada pasien yang pernah mendapatkan pengobatan TBC sebelumnya. [22] Hal itu bisa disebabkan karena meningkatnya kesadaran dan pengetahuan pasien TBC yang pernah mendapatkan pengobatan sebelumnya untuk mendapatkan pengobatan yang optimal demi kesembuhan mereka.…”

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Faktor Yang Mempengaruhi Pasien Tuberkulosis Resistan Obat Yang Tidak Memulai Pengobatan: Literature Review

Rizkiyani,

Syarif

2024

jkesmas

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Drug-resistant tuberculosis (DR TB) patients who have been diagnosed but not enrolled to treatment could be a source of primary transmission and the risk of increasing DR TB cases in the community. The aim of this literature review is to determine the factors that influence pre-treatment lost to follow up of DR TB patients by searching the literature through Google Scholar, ScienceDirect, ProQuest and PubMed which was published in the period 2016 to 2023 with the keywords "drug resistant tuberculosis", "treatment initiation", “enrollment rate”, and “pre-treatment lost to follow up”. Seven articles were obtained of which three research articles came from China, two from South Africa, one from India, and one from Ethiopia. Factors that influence DR TB patients not starting treatment include age, economic status, drug sensitive TB treatment status, inadequate health service infrastructure, lack of experienced clinicians, health seeking behavior, and health system delays. The low rate of DR TB treatment initiation requires special attention, both in terms of health services provided by the government and support from the community, in order to break the chain of transmission in the community.

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Section: Pembahasanunclassified

Faktor Yang Mempengaruhi Pasien Tuberkulosis Resistan Obat Yang Tidak Memulai Pengobatan: Literature Review

Rizkiyani,

Syarif

2024

jkesmas

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Association between experienced stigma, anxiety, depression and loneliness among people with drug‐resistant tuberculosis in Lagos Nigeria: The moderating role of social support

Adejumo,

Haffejee,

Jinabhai

et al. 2024

Tropical Med Int Health

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BackgroundThis study assessed the moderating effect of social support on the association between experienced stigma versus anxiety, depression and loneliness among people with drug‐resistant tuberculosis.MethodsA descriptive cross‐sectional study was conducted among 203 adults on treatment for drug‐resistant tuberculosis for at least 8 weeks. Validated scales were used to assess experienced stigma, anxiety, depression, loneliness and social support. Partial correlations and hierarchical multiple regression were used to determine the moderating effect of social support on the association between experienced stigma versus anxiety, depression and loneliness. The interaction was visualised using slope analysis.ResultsAnxiety, loneliness and depression were reported by 148 (72.9%), 114 (56.2%) and 128 (63.1%) of the 203 participants, respectively. Experienced stigma was positively associated with depression (B = 0.428, p < 0.001), anxiety (B = 0.374, p < 0.001) and loneliness (B = 0.285, p = 0.001). Social support was negatively associated with depression (B = −0.255, p < 0.001), anxiety (B = −0.406, p < 0.001) and loneliness (B = −0.270, p = 0.001). The impact of experienced stigma on depression was different at low (B = 0.567, SE = 0.115, p < 0.001) and high (B = 0.275, SE = 0.253, p = 0.024) groups of social support. Similarly, at low social support, the effect of experienced stigma on loneliness (B = 0.491, SE = 0.250, p < 0.001) and anxiety (B = 0.254, SE = 0.060, p = 0.044) was different compared to the effect of experienced stigma on loneliness (B = 0.275, SE = 0.253, p = 0.024) and anxiety (B = 0.127, SE = 0.094, p = 0.307) at high group of social support.ConclusionIn this study, social support reduced the effects of experienced stigma on anxiety, depression and loneliness suggesting that improving social support among people with drug‐resistant tuberculosis is crucial in reducing the negative effects of stigma on anxiety, depression and loneliness.

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Pretreatment attrition and treatment initiation delay among rifampicin-resistant tuberculosis patients in Lagos, Nigeria: a retrospective cohort study

Cited by 2 publications

References 22 publications

Faktor Yang Mempengaruhi Pasien Tuberkulosis Resistan Obat Yang Tidak Memulai Pengobatan: Literature Review

Faktor Yang Mempengaruhi Pasien Tuberkulosis Resistan Obat Yang Tidak Memulai Pengobatan: Literature Review

Association between experienced stigma, anxiety, depression and loneliness among people with drug‐resistant tuberculosis in Lagos Nigeria: The moderating role of social support

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