Pretreatment C-reactive protein was an independent prognostic factor for patients with diffuse large B-cell lymphoma treated with RCHOP

Wang, Jing; Zhou, Min; Wang, Xiaoyue; Xu, Jingyan; Chen, Bing; Ouyang, Jian

doi:10.1016/j.cca.2016.05.033

Cited by 18 publications

(13 citation statements)

References 27 publications

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“…For example, the C-reactive protein at diagnosis was reported to be associated with prognosis in R-CHOP-treated DLBCL patients. [ 13 ] Watanabe et al [ 14 ] suggested lymphocyte–monocyte ratio (LMR) should be a predictor too, consistent with the previous study by Belotti et al [ 15 ] The prognostic value of an interim fluorine-18-fluorodeoxyglucose positron emission tomography (PET-CT) [ 16 , 17 ] and Beta-2 microglobulin [ 18 ] was also evaluated. However, the ideal marker predicting the DLBCL remains elusive.…”

Section: Introductionsupporting

confidence: 53%

Prognostic role of pretreatment neutrophil-lymphocyte ratio in patients with diffuse large B-cell lymphoma treated with RCHOP

Wang

Zhou

et al. 2016

Medicine

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This study aims to investigate whether neutrophil to lymphocyte ratio (NLR) is an independent predictor in newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients in the rituximab era. Data from newly diagnosed DLBCL patients at Nanjing Drum Tower Hospital from 2006 to 2015 were retrospectively reviewed. We used the receiver operating characteristic (ROC) curve analysis to generate the optimal cutoff value for NLR. Among those 156 patients enrolled, the NLR was < 3.0 in 46.8% (73/156) of the patients, and the remaining 53.2% (83/156) had an NLR ≥ 3.0. Patients with higher pretreatment NLR were found to correlate with poorer OS and PFS than these with lower NLR (hazard ratio [HR] = 2.66, 95% confidence interval [CI] = 1.43–4.97, P = 0.002 and HR = 1.79, 95% CI = 1.05–3.07, P = 0.034, respectively). The multivariate Cox proportional hazard model analysis further showed that high NLR was found independently predictive of poor OS (HR = 0.40; CI = 0.19–0.84, P = 0.015) and PFS (HR = 0.57; CI = 0.33–0.98, P = 0.042). Consequently, pretreatment NLR was an independent prognostic predictor in patients with DLBCL in the rituximab era.

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Section: Introductionsupporting

confidence: 53%

Prognostic role of pretreatment neutrophil-lymphocyte ratio in patients with diffuse large B-cell lymphoma treated with RCHOP

Wang

Zhou

et al. 2016

Medicine

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“…(71%, 15/21) (6). In addition, serum b 2 -MG and CRP levels were the most important predictive factors for overall survival in DLBCL (29)(30)(31), which explains the lower median survival in our study compared to that noted by Laurent et al (6). The ESR and ferritin levels may indicate an inflammatory syndrome, but neither of them lead to a diagnosis of DLBCL or correlate with prognosis.…”

Section: Discussionsupporting

confidence: 37%

Primary Adrenal Lymphoma: Two Case Series From China

et al. 2022

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ObjectivePrimary adrenal lymphoma (PAL) is a rare form of adrenal mass. We summarize our experience in its clinical presentation, biochemical indexes, radiological features, pathological information, therapy regimens, and outcomes.MethodsThis was an institutional review board-approved retrospective review of medical records and surgical pathology specimens of patients with a diagnosis of PAL at the Chinese People’s Liberation Army General Hospital and the First Affiliate Hospital of Xiamen University between July 2007 and July 2017.ResultsTwenty-six patients were identified. The mean age at presentation was 60.84 ± 13.14 years with a male-to-female ratio of 2.25:1 (18:8). The most common presenting symptoms were loss of appetite (65%, 17/26), weight loss (62%, 16/26), abdominal pain (58%, 15/26), and fatigue (58%, 15/26). The levels of lactate dehydrogenase (75%, 15/20), β2-microglobulin (100%, 10/10), C-reactive protein (82%, 14/17), and ferritin (88%, 7/8) and the erythrocyte sedimentation rate (83%, 10/12) were elevated. Bilateral involvement was seen in 21 of 26 patients (81%); 12 of 19 evaluated patients with bilateral lesions (63%) were confirmed to have adrenal insufficiency. On computed tomography (CT), the mean tumor diameter was 7.31 ± 3.35 cm and the median Hounsfield density was 37.0 HU (range: 31.0–45.0 HU); 67% (10/15) and 27% (4/15) of lesions presented with mild and moderate enhancement after injection of contrast medium. 18F-fluorodeoxyglucose positron emission tomography (FDG PET)-CT revealed not only an adrenal tumor but also extra-adrenal lesions. Diffuse large B-cell lymphoma (DLBCL) was the most common phenotype (92%, 24/26). Ninety-two percent (24/26) of patients received chemotherapy while 8% (2/26) received unilateral adrenalectomy plus chemotherapy. The prognosis of PAL was poor, with a general survival time of 7.20 ± 5.18 months.ConclusionPAL is a rare disease. The clinical characteristics of PAL include loss of appetite and weight loss. Endocrine evaluation should be performed to determine whether patients have adrenal insufficiency, especially patients with bilateral lesions. FDG-PET appears to be more accurate than other imaging modalities in revealing extra-adrenal sites. Better therapy is required to improve the poor prognosis of PAL.

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“…The level of 20 mg/L for CRP was also selected as cutoff value in many previous reports. [ 6 , 30 ] It was shown that CRP >20 mg/L was a poor prognostic factor for 156 patients with diffuse large B-cell lymphoma treated with R-CHOP. [ 30 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor

et al. 2017

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Pretreatment C-reactive protein was an independent prognostic factor for patients with diffuse large B-cell lymphoma treated with RCHOP

Cited by 18 publications

References 27 publications

Prognostic role of pretreatment neutrophil-lymphocyte ratio in patients with diffuse large B-cell lymphoma treated with RCHOP

Prognostic role of pretreatment neutrophil-lymphocyte ratio in patients with diffuse large B-cell lymphoma treated with RCHOP

Primary Adrenal Lymphoma: Two Case Series From China

Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor

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