Pretreatment Effect of Alcoholic Olive Leaf Extract on Oxidative and Antioxidative Enzymes Status in Ovariectomized Rats

Nasirzadeh, Mohammadreza; Rasouli, A

doi:10.15296/ijwhr.2016.18

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…However, we did not find any cell degeneration and necrosis. Our result confirmed the protective effect of OLE in improving renal histopathological alterations as shown by previous studies (45,52,53). It might be related to its antioxidant property (54,55).…”

Section: Discussionsupporting

confidence: 91%

Protective effect of olive leaf (Olea europaea L.) extract against chronic exposure of liver and kidney tissues of Wistar rats to aluminum chloride

Meliana,

Ratnani,

Hasanatuludhhiyah

et al. 2024

J Herbmed Pharmacol

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Introduction: The liver and kidney are the main sites of aluminum (Al) accumulation. Lifetime exposure to significant amounts of Al is inevitable, hence its toxicity on the liver and kidney should be a health concern. Natural antioxidants have been proven to alleviate pathologies in various liver and kidney injuries. However, the effect of olive leaf extract (OLE) on Al-exposed animals is yet to be confirmed. This study aimed to investigate the OLE effect against AlCl3 chronic exposure in rats’ liver and kidneys. Methods:Thirty-two male Wistar rats were divided into four groups (n=8), including the control group, the AlCl3 group treated with 128 mg/kg AlCl3 solution, as well as AlCl3 +OLE50, and AlCl3 +OLE100 groups (Other than AlCl3 they received 50 and 100 mg/kg of OLE, respectively, 2 hours after AlCl3 administration). All treatments were given orally for 12 weeks. All groups were evaluated for liver and kidney histopathological features, then scoring was performed. Results: AlCl3 administrations produced histopathological lesions in the liver and kidney, indicated by increased liver necro-inflammatory grades, ballooning scores, and renal inflammatory cell infiltration (P<0.05). OLE100 mg/kg significantly reduced liver necroinflammatory grade, ballooning score, and kidney inflammatory cell infiltrations. The dose of 50 mg/kg also reduced these parameters (P<0.05), except for the liver necro-inflammatory grade. There was a significant correlation between OLE dose and liver necro-inflammatory grade and ballooning score amelioration. Conclusion: OLE ameliorates liver and kidney histopathological features induced by oral Al chronic exposure in a dose-dependent manner.

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Section: Discussionsupporting

confidence: 91%

Protective effect of olive leaf (Olea europaea L.) extract against chronic exposure of liver and kidney tissues of Wistar rats to aluminum chloride

Meliana,

Ratnani,

Hasanatuludhhiyah

et al. 2024

J Herbmed Pharmacol

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“…Another study proposed that treatment with OLE reduced MDA level in doxorubicin-induced cardiac, hepatic, and renal toxicity in rats (33). Nasirzadeh and Rasouli reported that oral administration of OLE 100 mg/kg for 30 days decreased MDA level in ovariectomized rats (34).…”

Section: Discussionmentioning

confidence: 99%

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

2017

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“…The content of MDA as a lipid peroxidation index was determined spectrophotometrically in 10% homogenates of liver and pancreas tissues (prepared in 0.9% NaCl) according to manufacturer's protocol(MDA assay kit; ZellBio, Germany) [17].…”

Section: Measurement Of Mdamentioning

confidence: 99%

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

Hosseini

Amani

Moshrefi

et al. 2020

IJT

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Background: Zinc Oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were divided into eight experimental, control and sham groups. They received ZnO nanoparticles at 4, 8, 25, 50, 100, or 200 mg/kg, or normal saline intraperitoneally for 30 days twice a week. Then, the blood samples of the rats were collected by heart puncture for biochemical analyses, and then sacrificed. Finally, the liver and pancreas tissues were harvested for histopathological examinations. Results: Significant amounts of nanoparticles were accumulated in the liver and pancreas of the rats, causing tissue and cellular damages. The ZnO nanoparticles reduced the levels of serum triglyceride, glucose, cholesterol, albumin, and increased the bilirubin and liver enzymes, such as ALT, AST, ALP, amylase and lipase at high doses. In addition, the evidence of histopathological lesions, hyperemia, inflammatory cell infiltration, and necrosis were noted in the liver and pancreas tissue slides upon microscopic examinations. Finally, the body and liver weights decreased in the rat groups receiving ZnO nanoparticle dose dependently. Conclusion: ZnO nanoparticles had toxic effects on the liver and pancreas, leading to destructive tissue and cellular changes in the rats.

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Pretreatment Effect of Alcoholic Olive Leaf Extract on Oxidative and Antioxidative Enzymes Status in Ovariectomized Rats

Cited by 7 publications

References 18 publications

Protective effect of olive leaf (Olea europaea L.) extract against chronic exposure of liver and kidney tissues of Wistar rats to aluminum chloride

Protective effect of olive leaf (Olea europaea L.) extract against chronic exposure of liver and kidney tissues of Wistar rats to aluminum chloride

Olive Leaves Extract Improved Sperm Quality and Antioxidant Status in the Testis of Rat Exposed to Rotenone

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

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