Pretreatment Glasgow Prognostic Score Correlated with Serum Histidine Level and Three-Year Mortality of Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma and Optimal Performance Status

Yeh, Kun‐Yun; Wang, Chao-Hung; Ling, Hang; Peng, Chia-Lin; Chen, Zih-Syuan; Hsia, Simon

doi:10.3390/nu14173475

Cited by 5 publications

(7 citation statements)

References 104 publications

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“…Therefore, future prospective multicenter studies are required to corroborate our findings. Second, numerous predictive biomarkers have been validated in many malignancies, such as the controlling nutritional status (CONUT) score [ 50 ], Glasgow prognostic score (GPS) [ 51 ], and prognostic nutritional index (PNI) [ 52 ], which could be further evaluated in the future study. Third, because of the histopathologic diversity, especially for the diverse heterogeneous subtypes of HNSTS, our cohort did not allow us to stratify the analysis of histopathologic subtypes.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Utility of Nutritional Risk Index in Patients with Head and Neck Soft Tissue Sarcoma

et al. 2023

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Background: The nutritional risk index (NRI) is an excellent indicator of nutritional status and a significant prognostic factor in several malignancies, but the relationship between NRI and the prognosis of head and neck soft tissue sarcoma (HNSTS) patients remains unclear. The aim of this study was to investigate the role of NRI in patients with HNSTS. Methods: We retrospectively reviewed patients with HNSTS between 1990 and 2021. In order to determine the optimal cut-off value of NRI, the Maximally selected log-rank statistic was performed. We evaluated the effect of NRI on overall survival (OS) and progression-free survival (PFS) by using the Kaplan–Meier method and Cox regression analysis. Then, OS and PFS nomograms based on NRI were constructed. Results: In total, 436 HNSTS patients were included in this study. The optimal cut-off value of NRI was 99.34. Patients with low-NRI showed significantly worse OS and PFS than patients with high-NRI, respectively (5-year OS rate of 43.0 vs. 70.8%, 5-year PFS rate of 29.0 vs. 45.0%, all p < 0.05). In the multivariate analysis, distant metastasis, deep tumor depth, tumor grade, and NRI were prognostic factors for both PFS and OS, and treatment modality was associated with OS but not PFS. The concordance indexes (C-indexes) of OS and PFS nomograms were 0.794 (95% CI, 0.759–0.829) and 0.663 (95% CI, 0.626–0.700), respectively, which also performed well in the validation set. Conclusions: NRI is an independent predictor of OS and PFS in HNSTS patients. The validated nomograms based on NRI provide useful predictions of OS and PFS for patients with HNSTS.

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Section: Discussionmentioning

confidence: 99%

Prognostic Utility of Nutritional Risk Index in Patients with Head and Neck Soft Tissue Sarcoma

et al. 2023

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“…Several studies, including a meta‐analysis, have reported the prognostic utility of the NLR, LMR, PLR, PNI, and HS‐mGPS in head and neck cancers 9–20,22–29 . Regarding previous reports on a systematic review and meta‐analysis, Yang et al 22 investigated a total of 25 studies and demonstrated that higher pretreatment NLR was associated with poorer prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…GPS is a useful systemic inflammatory index that presents the status of cancer cachexia, and the modified GPS (mGPS) is a more sensitive systemic inflammatory index than GPS for head and neck cancers 14 . Furthermore, recent studies have shown that high‐sensitivity mGPS (HS‐mGPS) is more sensitive than mGPS for prognostic utility in head and neck cancers 15,16 . However, limited information is available concerning SINBPI for OPC.…”

Section: Introductionmentioning

confidence: 99%

“… 14 Furthermore, recent studies have shown that high‐sensitivity mGPS (HS‐mGPS) is more sensitive than mGPS for prognostic utility in head and neck cancers. 15 , 16 However, limited information is available concerning SINBPI for OPC. Regarding the prognostic role of pretreatment SINBPI in OPC, a few studies have shown that NLR is an independent and prognostic predictor.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic values of systemic inflammation and nutrition‐based prognostic indices in oropharyngeal carcinoma

Oka

Satô

Ono

et al. 2023

Laryngoscope Investig Oto

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Objective: Pretreatment systemic inflammation and nutrition-based prognostic indices (SINBPI) have demonstrated significance. This study investigated the prognostic value of pretreatment SINBPI for patients with oropharyngeal cancer and identified unfavorable prognostic markers. Methods:We retrospectively reviewed the data of 124 patients with oropharyngeal squamous cell carcinoma (OPSCC) who received definitive treatment between January 2010 and December 2018. The prognostic utility of the neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index, and high-sensitivity modified Glasgow prognostic score (HS-mGPS) was assessed for disease-free survival (DFS), diseasespecific survival (DSS), and overall survival (OS) using univariate and multivariate analyses.Results: Multivariate analyses revealed that human papillomavirus (HPV) status and HS-mGPS were significantly associated with DFS, DSS, and OS. Patients with a HS-mGPS of 2 had a significantly higher rate of treatment-related deaths than those with a HS-mGPS of 0 or 1. The combination of the HS-mGPS and PLR had more accurate predictive ability in DFS and OS compared with the HS-mGPS alone, and the combination of the HS-mGPS and LMR had more accurate predictive ability in DSS and OS. Conclusion:Our results indicated that the HS-mGPS was a useful prognostic marker for patients with OPSCC, and combined markers consisting of the HS-mGPS and PLR or LMR may provide more accurate prognostic predictions.

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“…The GPS value is a parameter created by considering CRP and albumin values. Studies examining the connection between GPS and various cancers have been conducted in the literature, and the importance of GPS value has been demonstrated [22,23]. Recent studies have also investigated the relationship between cardiovascular diseases and GPS.…”

Section: "#$"=')"0"and>($() ?And=$8"#$"=')"0"and>($() !"#$"%And'(! "!...mentioning

confidence: 99%

Investigation of the relationship between prolonged ventilation and the Glasgow Prognostic Score after elective isolated coronary bypass surgeries in advanced-age patients

Guvenc

Engin

Kan

et al. 2023

The European Research Journal

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Objectives: Coronary artery bypass graft (CABG) surgeries are the most beneficial treatment method for atherosclerotic heart disease. Prolonged ventilation is a significant condition that poses risks such as infection, renal failure, prolongs hospital stays, and increases treatment costs. In this current study, we aimed to reveal the relationship between prolonged mechanical ventilation and Glasgow Prognostic Score (GPS), in patients aged 65 years and older who underwent isolated CABG. Methods: Patients aged 65 years and over who underwent elective isolated coronary bypass surgery with cardiopulmonary bypass in our clinic, between June 2017 and June 2022, were included in the study retrospectively. The patients who were extubated within eight hours of the surgeries were determined as Group 1, whereas those who were extubated after 8 hours were determined as Group 2. Results: Prolonged ventilation occurred in 101 (20.7%) patients (Group 2). The median age of the 385 patients included in Group 1 and 101 patients in Group 2 was 68 (66 to 91) and 71 (66 to 88) years, respectively (p = 0.216). The two groups were similar in regards to gender, hypertension, smoking, diabetes mellitus, body mass index, history of cerebrovascular accident and left ventricular ejection fraction rates. In the multivariate analysis, left ventricular ejection fraction <35% (OR: 1.136, 95% CI: 1.065-1.652, p = 0.029), total perfusion time (OR: 1.190, 95% CI: 1.040-1.659, p = 0.012), and GPS = 2 (OR: 1.479, 95% CI: 1.130-2.169, p = 0.004) were determined as independent predictors for prolonged ventilation. Conclusions: GPS value calculated preoperatively in elderly patients is a parameter that indicates the increased ventilation need. With the GPS score evaluation, patient groups at risk for prolonged ventilation can be identified and necessary precautions can be undertaken.

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Pretreatment Glasgow Prognostic Score Correlated with Serum Histidine Level and Three-Year Mortality of Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma and Optimal Performance Status

Cited by 5 publications

References 104 publications

Prognostic Utility of Nutritional Risk Index in Patients with Head and Neck Soft Tissue Sarcoma

Prognostic Utility of Nutritional Risk Index in Patients with Head and Neck Soft Tissue Sarcoma

Prognostic values of systemic inflammation and nutrition‐based prognostic indices in oropharyngeal carcinoma

Investigation of the relationship between prolonged ventilation and the Glasgow Prognostic Score after elective isolated coronary bypass surgeries in advanced-age patients

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