Pretreatment neutrophil/lymphocyte ratio but not platelet/lymphocyte ratio has a prognostic impact in multiple myeloma

Abstract

Our study suggests that NLR not PLR can be acted as an independent prognostic factor for analyzing the clinical outcome of MM patients.

Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs

“…Increased NLR is a recently identified independent negative prognostic factor in people with MM, with a high NLR associated with shorter overall survival and progression‐ or event‐free survival times . Similarly, we identified an association between increased NLR and shorter OST, PFS, DFI, and SFR in dogs.…”

“…Increased NLR is a recently identified independent negative prognostic factor in people with MM, with a high NLR associated with shorter overall survival and progression-or event-free survival times. [19][20][21][22][23][24] Similarly, we identified an association between increased NLR and shorter OST, PFS, DFI, and SFR in dogs. In neoplastic processes such as MM, an increased NLR may reflect a decreased antitumor immune response by lymphocytes with concurrent protumor activity by neutrophils, particularly an IL-6-mediated neutrophilia.…”

“…2 In contrast, studies of MM in humans have not consistently found hypercalcemia, osteolytic lesions, and Bence-Jones proteinuria to be prognostic, 7,8 and instead use risk stratification models that primarily rely on cytogenetics, gene expression profiling, the International Staging System, and serum lactate dehydrogenase activity as prognostic markers. [9][10][11] Other studies have evaluated factors such as renal disease, 7,8,[12][13][14][15][16][17][18] neutrophil-tolymphocyte ratio (NLR), [19][20][21][22][23][24] platelet-to-lymphocyte ratio (PLR), 23,24 and anemia, [25][26][27] which have negatively affected outcome. Several studies in veterinary oncology have evaluated NLR as a prognostic factor in dog, [28][29][30][31] but no studies, to the authors' knowledge, have evaluated NLR or PLR in dogs with MM.…”

Can Neutrophil‐to‐Lymphocyte Ratio, Monocyte‐to‐Lymphocyte Ratio, and Platelet‐to‐Lymphocyte Ratio at Day +100 be used as a prognostic marker in Multiple Myeloma patients with autologous transplantation?

“…The studies have examined its impact on MM as well. High NLRs in patients with MM are associated with negative prognosis in these studies . The specific mechanism involved in the interaction between increased NLR and poor prognosis of multiple myeloma patients is incompletely understood.…”

“…Lihui and Shi calculated the cutoff value of NLR as 4. In other studies, NLR cutoff values were given as 2, 2.25, and it was obtained as 2.78 . The cutoff values for NLR were calculated as 3.19 on day −5 prior ASCT and 1.46 on day +100 after ASCT in our study.…”