Pretreatment Neutrophil–Lymphocyte Ratio

Gao, Fangyuan; Li, Xiaoshu; Geng, Mingfan; Ye, Xieqiong; Liu, Huimin; Liu, Yao; Wu, Gang; Wang, Xianbo

doi:10.1097/md.0000000000000639

Cited by 50 publications

(24 citation statements)

References 25 publications

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“…Recently, NLRs have also been used to help differentiate primary breast carcinoma from benign proliferative breast disease [97]. NLR has also recently been applied for early detection and as a prognostic marker in gastric cancer [98], early diagnosis of ovarian cancer [99], and prognosis and survival prediction in colon cancer [100] and HCC [101], among others. The use of NLRs and other systemic inflammation markers could help not only aid in treatment choices and prognostic predictions, but also potentially enhance early detection of cancer.…”

Section: Targeting Neutrophil-mediated Inflammation In the Tumor Micrmentioning

confidence: 99%

Neutrophils in the Tumor Microenvironment

Powell

Huttenlocher

2016

Trends in Immunology

483

413

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Neutrophils are the first responders to sites of acute tissue damage and infection. Recent studies suggest that in addition to neutrophil apoptosis, resolution of neutrophil inflammation at wounds can be mediated by reverse migration from tissues and transmigration back into the vasculature. In settings of chronic inflammation, neutrophils persist in tissues, and this persistence has been associated with cancer progression. However, the role of neutrophils in the tumor microenvironment remains controversial, with evidence for both pro- and anti-tumor roles. Here we review the mechanisms that regulate neutrophil recruitment and resolution at sites of tissue damage, with a specific focus on the tumor microenvironment. We discuss the current understanding as to how neutrophils alter the tumor microenvironment to support or hinder cancer progression, and in this context outline gaps in understanding and important areas of inquiry.

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Section: Targeting Neutrophil-mediated Inflammation In the Tumor Micrmentioning

confidence: 99%

Neutrophils in the Tumor Microenvironment

Powell

Huttenlocher

2016

Trends in Immunology

483

413

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“…Moreover, 70-90 % of HCCs are a result of cirrhosis [ 6 , 7 ]. In recent studies, inflammation-based prognostic scores, such as the combination of albumin and lymphocyte counts used in the prognostic nutritional index (PNI) [ 5 , 8 ], the combination of neutrophil and lymphocyte counts in the neutrophil/ lymphocyte ratio (NLR) [ 9 – 11 ], and the combination of platelet (PLT) and lymphocyte counts in the PLT/lymphocyte ratio (PLR) [ 12 ], have proved valuable in HCC prediction. In addition, recent studies [ 13 – 15 ] suggest that a simple and accurate biochemical marker of liver fibrosis and cirrhosis, i.e., the aspartate aminotransferase (AST)/ PLT count ratio index (APRI), may be 1) an indicator of postoperative prognosis in early stage hepatitis B (HBV)-related HCC patients, or 2) a marker of HCC risk in HBV patients,.…”

Section: Introductionmentioning

confidence: 99%

A novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI)

Liang

et al. 2016

BMC Cancer

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BackgroundThe occurrence and development of hepatocellular carcinoma (HCC) depends largely on such non-tumor factors as inflammatory condition, immune state, viral infection and liver fibrosis. Various inflammation-based prognostic scores have been associated with survival in patients with HCC, such as the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR) and the prognostic nutritional index (PNI). The aspartate aminotransferase/platelet count ratio index (APRI) is thought to be a biomarker of liver fibrosis and cirrhosis. This study aims to evaluate the ability of these indices to predict survival in HCC patients after curative hepatectomy, and probe the increased prognostic accuracy of APRI combined with established inflammation-based prognostic scores.MethodsData were collected retrospectively from 321 patients who underwent curative resection for HCC. Preoperative NLR, PLR, PNI, APRI and clinico-pathological variables were analyzed. Univariate and multivariate analyses were performed to identify the predictive value of the above factors for disease-free survival (DFS) and overall survival (OS).ResultsUnivariate analysis showed that NLR, PLR, PNI and APRI were significantly associated with DFS and OS in HCC patients with curative resection. Multivariate analysis showed that NLR and APRI were superior to PLR and PNI, and both were independently correlated with DFS and OS. Preoperative NLR >2 or APRI >1.68 predicted poor prognosis of patients with HCC after hepatectomy. Furthermore, the predictive range of NLR combined with APRI was more sensitive than that of either measure alone.ConclusionsPreoperative NLR and APRI are independent predictors of DFS and OS in patients with HCC after surgical resection. Higher levels of NLR or APRI predict poorer outcomes in HCC patients. Intriguingly, combining NLR and APRI increases the prognostic accuracy of testing.

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“…Recent data have shown that inflammation is a critical component of tumor progression, and it is associated with a poor prognosis in various tumors, as an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. 7 – 11 Studies have shown that a high level of neutrophils is associated with angiogenesis, which plays an important role in the growth and metastasis of malignancy. Furthermore, DNA damage and tumor metastasis suppress lymphocyte activity through the upregulation of cytokines that counteract the antitumor immune response.…”

Section: Introductionmentioning

confidence: 99%