Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

Hossen, Md. Amjad; Reza, A. S. M. Ali; Ahmed, Ayaz; Islam, Md. Kamrul; Jahan, Israt; Hossain, Rahni; Khan, Mohammad Firoz; Maruf, Mohammad Rifat Alam; Haque, Md. Areeful; Ma, Rahman

doi:10.1016/j.biopha.2020.111211

Cited by 47 publications

(32 citation statements)

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“…Moreover, a study demonstrated an elevated level of ROS produces many known mechanisms like mitochondrial deregulations, lipid cellular structures, neurotransmitter deregulations, and cellular respiration, which correlates with anxiety and depression (Rammal et al, 2010 (Griebel et al, 2000). Our results revealed that the ad- In computer-aided drug design, in silico molecular docking study is a pivotal tool that predicts the binding activity of compounds against particular proteins (Hossen et al, 2021;S. Khan et al, 2019).…”

Section: Discussionsmentioning

confidence: 71%

“…In computer‐aided drug design, in silico molecular docking study is a pivotal tool that predicts the binding activity of compounds against particular proteins (Hossen et al., 2021; S. Khan et al., 2019). Besides, the possible molecular mechanism of actions of different pharmacological activities is determined comprehensively through molecular docking.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the filtrate was evaporated by a rotary evaporator (RE200, Bibby Sterling, UK) under reduced pressure and temperature below 50℃. The methanol extract (Me‐BLL) yield value was noted as 16 g, and until the experiment was conducted, Me‐BLL was stored at 4℃ (Hossen et al., 2021).…”

Section: Methodsmentioning

confidence: 99%

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Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer‐aided model

Hossen¹,

Reza²,

Amin³

et al. 2021

Food Science & Nutrition

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Blumea lacera is an edible plant with imperative medicinal values. However, the anxiolytic and antidepressant roles of B. lacera have not been well‐explained. Therefore, the current study aims to explore the impending bioactive metabolites and roles of B. lacera methanol leaf extract (Me‐BLL) in attenuating anxiety and depression through several experimental and computer‐aided approaches. The chemical characterization of Me‐BLL was performed through standard phytochemical and GC‐MS analyses. To explore the neuropharmacological insights, Swiss albino mice were treated with Me‐BLL at doses of 200–400 mg/kg, p.o. The anxiolytic effects were observed employing elevated plus maze (EPM), light–dark box (LDB), and hole‐board (HBT) tests, while antidepressant effects were evaluated using forced swimming (FST) and tail suspension tests (TST). Diazepam (1 mg/kg, i.p.) and fluoxetine HCl (20 mg/kg, p.o.) were used as the reference standard. The phytochemical analyses revealed several bioactive metabolites, including higher contents of total phenolics and flavonoids. The EPM and LDB tests demonstrated an increased time spent in open arms and light box, and the HBT showed an increased number of head dipping, indicating the anxiolytic effects of Me‐BLL. The TST and FST revealed a decrease in immobility time, meaning the persuasive antidepressant effects. The antioxidative effects of Me‐BLL have also been observed prominently. Correspondingly, the computer‐aided investigation confirmed several bioactive lead molecules. Specifically, thymol and cuminol revealed potential anxiolytic and antioxidant effects, while stigmast‐5‐en‐3.beta.‐ol and gamma‐sitosterol possessed promising antidepressant effects. Taken these results as a base, the plant has imperative potentials in managing anxiety and depression‐like disorders.

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Section: Discussionsmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer‐aided model

Hossen¹,

Reza²,

Amin³

et al. 2021

Food Science & Nutrition

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“…Values are representing as mean ± SEM (n = 3). Plants containing flavonoids are responsible for a variety of pharmacological activities including anti-inflammatory and anti-nociceptive activity [23]. Also, the presence of alkaloids in plant extract blocks the metabolic pathway of arachidonic acid to prevent inflammation [24].…”

Section: Resultsmentioning

confidence: 99%

Xylia xylocarpa (Roxb.) Taub. Leaves Ameliorates Inflammation and Pain in Experimental Mice and Computer-Aided Model

Chowdhury

Chowdhur

Hasan

et al. 2021

Walailak J Sci & Tech

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Xylia xylocarpa (Roxb.) Taub. is traditionally used to treat several diseases, including leprosy, wound healing, gonorrhea, rheumatism, anemia, diarrhea and ulcer. This study evaluated the anti-inflammatory and anti-nociceptive activities of methanolic extract of Xylia xylocarpa leaves (MEXX) via in vitro, in vivo as well as in silico models. In vitro anti-inflammatory activity was determined by human red blood cell membrane stabilization study and protein denaturation while in vivo anti-nociceptive activity was examined by the acetic acid-induced writhing test (AAWT) and formalin-induced paw licking test (FIPLT). Additionally, trans-5-hydroxypipecolic acid was an identified compound of MEXX which was subjected to molecular docking analysis followed by ADME/T and toxicity analysis. Qualitative phytochemical screening revealed that MEXX was enriched with carbohydrates, flavonoids, alkaloids, proteins, tannins and showed significant total phenolic (1222.66 ± 0.66 mg GAE/g dried extract) and flavonoids contents (325.33 ± 1.76 mg QE/g dried extract) in quantitative phytochemical screening. Inflammatory studies unveiled that; MEXX significantly (p < 0.05) inhibited the hemolysis of membrane and protein at different concentrations (31.25 - 1000 μg/mL). The extract also displayed statistically significant analgesic responses in the acetic acid and formalin-induced test at several doses (200 and 400 mg/kg b.w). In AAWT, the extract exhibited 13.67 and 51.37 % inhibition of writhing at the doses 200 and 400 mg/kg body weight respectively. In formalin-induced paw licking test, the early phase pain inhibition was 54.64 % at the concentration of 400 mg/kg while during the latter phase at 400 mg/kg, the inhibition of pain was 43.82 %. According to molecular docking analysis, trans-5-hydroxypipecolic acid demonstrated a promising docking score against PDE4, COX-1, and COX-2 along with satisfied pharmacokinetic and toxicological properties. Finally, from the results it could be concluded that MEXX has potential anti-inflammatory and an-nociceptive effects that should require further investigation. HIGHLIGHTS Xylia xylocarpa minimizes the inflamation and pain Xylia xylocarpa showed significant analgesic activity Xylia xylocarpa revealed polyphenolic compounds including phenol, and flavonoid In in silico, trans-5-hydroxypipecolic acid possessed significant analgesic activity against COX-1 and COX-2 GRAPHICAL ABSTRACT

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“…CAM covers products obtained from nature (herbs and probiotics), mind, and body practices (acupuncture, chiropractic, massage therapy, hypnosis, spiritual healing, meditation, etc.) and other traditional medical practices such as African Corresponding author: A. S. M. Ali Reza, E-mail:alirezaru@gmail.com DOI: https://doi.org/10.3329/bpj.v24i2.54714 traditional medicine, Chinese traditional medicine, and Indian Ayurvedic medicine (Babar et al, 2019;Bellah et al, 2017;Haque et al, 2020;Hossen et al, 2021;Rahman et al, 2021;Uddin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude, Perception of Biological Science and Healthcare Professional Students to Complementary and Alternative Medicine Health Belief and Practice in Southeastern Region of Bangladesh: A Comparative Study

et al. 2021

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The health professionals require scientific knowledge to advise their patients on complementary and alternative medicines (CAM). Previously, several studies were conducted regarding the CAM perception, attitude and use on health care professionals only; in contrast, our study encompasses both students of health care professionals and other disciplines. The aim of this study was to compare the attitudes and perception about CAM practices between students of biological sciences (Biochemistry and Molecular Biology, Microbiology and Botany) and health care professionals (Pharmacy and medical students) in public and private universities located in the southeastern region in Bangladesh. The questionnaire-based study conducted on 332 systematically sampled students (four private and one public universities) located in the southeastern region in Bangladesh. The cross-sectional study was conducted from March to July, 2018. All students showed a positive attitude towards CAM use. Herbal medicine, homeopathy, nutritional supplements followed by hypnosis, massage, spiritual healing, and meditation were the most commonly known and used CAM modalities. Most of the students (40.7%) believed that the integration of CAM and conventional medicine should be essential in health care setting. The major obstacles for CAM use are patient interest (48.2%) and lack of physician interest (43.4%). In addition, 36.7% students believed that CAM practices should be included in their school’s curriculum. Moreover, 39.5% students assumed that CAM knowledge is important to their daily life. Biological sciences and healthcare professional students of Bangladesh showed positive perception on CAM uses. Bangladesh Pharmaceutical Journal 24(2): 159-167, 2021

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Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction

Cited by 47 publications

References 42 publications

Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer‐aided model

Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer‐aided model

Xylia xylocarpa (Roxb.) Taub. Leaves Ameliorates Inflammation and Pain in Experimental Mice and Computer-Aided Model

Knowledge, Attitude, Perception of Biological Science and Healthcare Professional Students to Complementary and Alternative Medicine Health Belief and Practice in Southeastern Region of Bangladesh: A Comparative Study

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