Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia

Abstract

Disseminated intravascular coagulation (DIC) is a lethal situation in severe infections, characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. Current clinical trials are not promising. In this study, we investigated the protective effect of curcumin in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by sustained infusion of LPS (10 mg/kg body weight) for 4 h through the tail vein. Curcumin (60 mg/kg body weight) was given intraperitoneally 3 h before LPS infusion. Results showed that, in vivo, curcumin reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-alpha levels and the consumption of peripheral platelets and plasma fibrinogen. Furthermore, in vivo curcumin also has the effect of preventing the formation of fibrin deposition in the glomeruli of kidney. These results reveal the therapeutic potential of curcumin in infection-related coagulopathy of DIC.

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

“…A dose of curcumin of 50-500 mg·kg -1 ·day -1 was used for most of these studies. Endotoxin has been shown to induce septic shock in animals, in part, through the production of TNF, and this condition has been shown to be reversed by curcumin (Siddiqui et al, 2006;Chen et al, 2007;2008;Huang et al, 2008;Nishida et al, 2010). Decreased TNF-a levels have also been noted in tumour-bearing animals treated with this polyphenol (Leyon and Kuttan, 2003).…”

“…• Reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-a levels and the consumption of peripheral platelets and plasma fibrinogen (Chen et al, 2007).…”

Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture

“…The potential therapeutic benefits of nature diet compound are receiving more and more attention. Curcumin, a diferuloylmethane, is a major active component of the food flavor turmeric (Curcuma longa) that has been shown to have anti-oxidation [14][15][16] and antiinflammation effects [17][18][19][20]. Besides, several reports documented that curcumin was protective to 6-OHDA-, MPP + -and MPTP-induced neurotoxicity through its antioxidation effect [21][22][23].…”

Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products

“…Curcumin decreased the levels of TNF-and interleukin-6 in mouse plasma after endotoxin-induced hepatic dysfunction and oxidative stress (Kaur et al, 2006) and also inhibited the increase of both IL-1 and TNF-in a chronic model of inflammation in rats (Banerjee et al, 2003). Systemic pretreatment with curcumin abrogates the rise in circulating proinflammatory cytokines and body temperature and prevents the onset of disseminated intravascular coagulation (Chen et al, 2007). The effects of EGCG on the inflammatory cytokine production are thought to be cell typedependent.…”