Pretreatment serum lactate dehydrogenase as additional staging parameter in patients with small-cell lung carcinoma

Stokkel, Marcel P. M.; Eck-Smit, Berthe L. F. van; Zwinderman, A. H.; Willems, L. N. A.; Pauwels, E. K. J.

doi:10.1007/s004320050157

Cited by 14 publications

(7 citation statements)

References 15 publications

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“…Previous studies have reported that PS score, disease extent, LDH level, CEA and NSE significantly correlates with overall survival benefit in patients with SCLC8242526. These findings are consistent with the results of our studies, which demonstrated that better PS, limited staging, and normal serum levels of LDH were significantly associated with a longer survival than those with patients with a poor PS, extensive staging, and elevated serum LDH levels (Table 1).…”

Section: Discussionsupporting

confidence: 92%

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Ratio of C-Reactive Protein/Albumin is An Inflammatory Prognostic Score for Predicting Overall Survival of Patients with Small-cell Lung Cancer

Zhou

Zhan

Hong

et al. 2015

Sci Rep

138

117

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Recent studies have indicated that the C-reactive protein/ albumin (CRP/Alb) ratio is associated with clinical outcomes in patients with hepatocellular carcinoma (HCC). We examined the prognostic value of this ratio in patients with small-cell lung cancer (SCLC). In this retrospective study, a total of 367 eligible SCLC patients were analyzed and the correlation between the pretreatment CRP/Alb ratio and overall survival (OS) was investigated. The optimal cutoff level of CRP/Alb ratio was at 0.441. A low and high CRP/Alb ratio was assigned to 65.1% and 34.9% of patients, respectively. The median OS of patients with a high CRP/Alb ratio was worse than those in the low group (13.70 vs 18.90 months HR, 1.34; p = 0.005). Disease stage (p < 0.001), performance status (PS) (p < 0.001) and pretreatment LDH (p < 0.001) were also significant predictors of OS. Multivariate analyses showed that the CRP/Alb ratio is an independent prognostic factor (p = 0.025). This study demonstrated that the CRP/Alb ratio could independently predict OS in patients with SCLC, and had comparable prognostic value to other known prognostic markers. Therefore, the CRP/Alb ratio could have prognostic value and be a measurable biomarker in patients with SCLC.

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Section: Discussionsupporting

confidence: 92%

“…These prognostic markers are associated with overall survival (OS) in SCLC8910. Of the prognostic factors, PS and disease stage are important prognostic indicators for SCLC1112.…”

mentioning

confidence: 99%

Ratio of C-Reactive Protein/Albumin is An Inflammatory Prognostic Score for Predicting Overall Survival of Patients with Small-cell Lung Cancer

Zhou

Zhan

Hong

et al. 2015

Sci Rep

138

117

View full text Add to dashboard Cite

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“…We have found that elevated LDH was an independent poor prognostic factor for survival, as was found in other studies [2,7,8,10,12,13]. Elevated LDH levels may reflect occult disease which cannot be detected with current imaging techniques, tumor burden, metabolic activity of malignancy, or increased risk of tumor recurrence [13]. Serum LDH is also known to play an important role in the prediction of the metastatic pattern.…”

Section: Discussionmentioning

confidence: 75%

Prognostic factors in patients with small cell lung carcinoma

et al. 2009

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“…Under these conditions, tumor cells characteristically show rapid anaerobic glycolysis,23 a process in which LDH plays a central role 24. Not surprisingly, then, various malignant tumors have been reported to express higher levels of LDH isoforms than healthy cells, and S-LDH levels in these patients are higher than in healthy controls 9,10,25. The elevated S-LDH may reflect, at least in part, release of the enzyme from malignant cells 16,26.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of pretreatment serum levels of lactate dehydrogenase in nonmetastatic nasopharyngeal carcinoma: single-site analysis of 601 patients in a highly endemic area

Wei

Zeng

et al. 2014

OTT

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BackgroundNumerous studies have generated promising but incomplete evidence for the prognostic value of pretreatment serum levels of lactate dehydrogenase (S-LDH) in nasopharyngeal carcinoma (NPC).MethodsPretreatment serum levels of S-LDH in 601 patients with NPC were measured before treatment, and their associations with overall survival and tumor-free survival were studied. Univariate and multivariate analysis of subgroups was used to evaluate the prognostic value of S-LDH in early-stage and late-stage NPC separately.ResultsPretreatment S-LDH levels were significantly lower in T1+2 patients than in T3+4 patients, lower in N0+1 patients than in N2+3 ones, and lower in stage I + II patients than in III + IV ones. Multivariate analysis showed that among patients with late-stage NPC, high pretreatment S-LDH levels >225 U/L were an independent predictor of poor overall survival and tumor-free survival. Among patients with early-stage NPC, pretreatment S-LDH levels >171 U/L, which overlap with the normal range, were an independent predictor of shorter overall survival and tumor-free survival.ConclusionPretreatment S-LDH levels may be a reliable biomarker for predicting the long-term prognosis of patients with early-stage or late-stage NPC.

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Pretreatment serum lactate dehydrogenase as additional staging parameter in patients with small-cell lung carcinoma

Abstract: These results suggest that pretreatment LDH may be used as an additional staging parameter in SCLC, which can identify prognostic subgroups before treatment.

Cited by 14 publications

References 15 publications

Ratio of C-Reactive Protein/Albumin is An Inflammatory Prognostic Score for Predicting Overall Survival of Patients with Small-cell Lung Cancer

Ratio of C-Reactive Protein/Albumin is An Inflammatory Prognostic Score for Predicting Overall Survival of Patients with Small-cell Lung Cancer

Prognostic factors in patients with small cell lung carcinoma

Prognostic value of pretreatment serum levels of lactate dehydrogenase in nonmetastatic nasopharyngeal carcinoma: single-site analysis of 601 patients in a highly endemic area

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