Pretreatment tumour-antigen Ta-4 in serum of patients with squamous cell carcinoma of the uterine cervix

Kenter, G.G.; Bonfrèr, J. M. G.; Heintz, A.P.M.

doi:10.1038/bjc.1987.176

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…TA-4 or its subfraction of SCCA can be found in a variety of squamous cell malignancies, including those from uterine cervix (13)(14)(15)(16)(17)(18)(19), lung (20), esophagus (21), head and neck (22), anal canal (23), skin (24), and oral cavity (20). Previous studies demonstrated that the pre-treatment serum TA-4 or SCCA levels are positively related to the clinical stages of the cancers (14)(15)(16)(20)(21)(22)(23)(24). This indicates that the serum concentration of TA-4 or SCCA can reflect the extent of the cancers and is proportional to the tumor burden.…”

Section: Discussionmentioning

confidence: 99%

“…The pre-treatment serum TA-4 levels are positively related to the clinical stages of cervical SCC (14) and can be used to predict the extent of the cervical SCC (15,16) or the prognosis of the cervical SCC (17). In addition, serial serum TA-4 determinations can provide a potential means for monitoring the effects of individual therapy for cervical SCC (14,18) and for evaluating the regression or progression of cervical SCC (18,19).…”

Section: The Chinese Medicinal Herbs Radix Astragale Fructus Lycii Andmentioning

confidence: 99%

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Levamisole and/or Chinese medicinal herbs can modulate the serum level of squamous cell carcinoma associated antigen in patients with erosive oral lichen planus

Sun¹,

Chiang²

2001

J Oral Pathology Medicine

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The serum levels of squamous cell carcinoma associated antigen (SCCA) were determined by a microparticle enzyme immunoassay in a group of patients with stage I oral squamous cell carcinoma (OSCC), major or minor type erosive oral lichen planus (EOLP), recurrent aphthous stomatitis (RAS), Behçet's disease (BD), oral leukoplakia (OL), or oral submucous fibrosis (OSF), and in normal control subjects. About 97% of the normal control subjects and the patients with minor type EOLP, RAS, BD, OL or OSF had a serum level of SCCA within the normal limit of 1.2 ng/ml. However, 6 of the 12 (50%) patients with stage I OSCC and 14 of the 31 (45.2%) patients with major type EOLP had a serum level of SCCA greater than 1.2 ng/ml. The mean serum level of SCCA in stage I OSCC patients (1.38+/-1.16 ng/ml) or in major type EOLP patients (1.32+/-1.23 ng/ml) was significantly higher than that in normal control subjects (P<0.001) and that in the patients with minor type EOLP (P<0.001), RAS (P<0.001), BD (P<0.05), OL (P<0.05), or OSF (P<0.05). Either major or minor type EOLP patients could obtain a significant mean reduction of the serum SCCA level of 0.34-0.63 ng/ml after treatment with levamisole and/or Chinese medicinal herbs for 1-30 months. Combination therapy with levamisole plus Chinese medicinal herbs could achieve a shorter duration of treatment to get complete remission than the single therapy with either levamisole only or Chinese medicinal herbs only. We conclude that levamisole and/or Chinese medicinal herbs can modulate the serum SCCA level in EOLP patients. SCCA may be a useful marker in evaluating therapeutic effects and in monitoring the disease status of EOLP. For EOLP patients, the combination therapy is superior to the single therapy of levamisole or of Chinese medicinal herbs.

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Section: Discussionmentioning

confidence: 99%

Section: The Chinese Medicinal Herbs Radix Astragale Fructus Lycii Andmentioning

confidence: 99%

Levamisole and/or Chinese medicinal herbs can modulate the serum level of squamous cell carcinoma associated antigen in patients with erosive oral lichen planus

Sun¹,

Chiang²

2001

J Oral Pathology Medicine

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Bedeutung von SCC als Tumormarker bei Plattenepithelkarzinomen

Elling

Pink

1992

Tumormarker Und Immunszintigraphie in Der Gynäkologischen Onkologie

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Prognostic significance of serum concentration of squamous cell carcinoma antigen in anal epidermoid carcinoma

et al. 1993

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The prognostic significance of pre-treatment serum concentration of squamous cell carcinoma antigen (SCCAg) was investigated in a population of 60 patients with anal epidermoid cancer. Serum concentration was determined during the period 1985-90. The patients were followed until December 1991. An antigen level above 2.0 ng/ml was classified as elevated. Thirty-eight patients had T1-2 tumours, while 22 had T3-4 tumours. Sixteen of the 20 patients (80%) with an elevated SCCAg concentration relapsed or had residual tumour after conclusion of primary therapy, compared to 8 of 40 (20%) with a normal concentration (P = 0.00001). Six patients of 40 (15%) with a normal SCCAg had died at the end of follow-up compared to 10 of 20 (50%) with an elevated value (P = 0.006). For patients with T1-2 tumours 2 of 29 (7%) with a normal SCCAg had died with or from their cancer compared to 3 of 9 (33%) with an elevated value (P = 0.14); for T3-4 tumours these figures were 3 of 11 (P = 0.14); for T3-4 tumours these figures were 3 of 11 (27%) and 7 of 11 (64%) respectively (P = 0.009). Actuarial survival analyses for patients with normal vs elevated SCCAg concentration showed that the projected five year overall survival was 81% for those with a normal level and 43% for those with an elevated level (P = 0.004). For tumour specific survival the figures were 83% vs 45% (P = 0.004).(ABSTRACT TRUNCATED AT 250 WORDS)

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Pretreatment tumour-antigen Ta-4 in serum of patients with squamous cell carcinoma of the uterine cervix

Cited by 5 publications

References 9 publications

Levamisole and/or Chinese medicinal herbs can modulate the serum level of squamous cell carcinoma associated antigen in patients with erosive oral lichen planus

Levamisole and/or Chinese medicinal herbs can modulate the serum level of squamous cell carcinoma associated antigen in patients with erosive oral lichen planus

Bedeutung von SCC als Tumormarker bei Plattenepithelkarzinomen

Prognostic significance of serum concentration of squamous cell carcinoma antigen in anal epidermoid carcinoma

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