Pretreatment with Lornoxicam, a Cyclooxygenase Inhibitor, Relieves Postoperative Immuno-Suppression after Total Abdominal Hysterectomy

Intravenous Lornoxicam Is More Effective than Paracetamol as a Supplemental Analgesic After Lower Abdominal Surgery: A Randomized Controlled Trial

“…The proven effectiveness of lornoxicam as a suitable adjuvant for postoperative pain relief was clinically evident by lower pain scores at rest and during coughing, as well as by a reduction in morphine consumption during the first 12 and 24 h. Our results agree with several studies that have shown that lornoxicam was highly effective in alleviating postoperative pain and reduced the need for rescue analgesics following different abdominal surgeries [6,[17][18][19]. In postoperative pain management, lornoxicam has been demonstrated to have potency similar to morphine [20] and meperidine [21].…”

“…The dose of IV lornoxicam selected in the present study (16 mg) was based on several previous reports [7, 27–30]. Although the lower dose provided effective pain relief, lornoxicam 16 mg may produce a more potent and longer analgesic effect [7, 17, 27, 28]. In addition, pretreatment with lornoxicam 16 mg relieved postoperative immunosuppression more effectively than the 8 mg dose administered by other investigators in patients undergoing total abdominal hysterectomy [17].…”