Pretreatment With Pro- and Synbiotics Reduces Peritonitis-Induced Acute Lung Injury in Rats

Tok, Demet; İlkgül, Özer; Bengmark, S; Aydede, Hasan; Erhan, Yamaç; Taneli, Fatma; Ulman, Cevval; Vatansever, Seda; Köse, Can; Ok, Gülay

doi:10.1097/01.ta.0000236019.00650.00

Cited by 25 publications

(24 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tok and et al showed that symbiotic treatment reduced pulmonary tissue injury in intra-abdominal sepsis [31]. In the present study, it was observed that probiotic treatment reduced both pancreatic and pulmonary tissue damage in ANP.…”

Section: Discussionmentioning

confidence: 53%

Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

Karen

Yüksel

Akyürek

et al. 2010

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 53%

Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

Karen

Yüksel

Akyürek

et al. 2010

Journal of Surgical Research

View full text Add to dashboard Cite

“…In this study the serum endotoxin level in alcohol-treated rats was 190.0 ± 140.7 pg ml -1 , which was over 19-fold higher than in the LAB-fed group (10.5 ± 9.3 pg ml -1 , P = 0.01). In our previous study [16,17], and also in various other studies [18][19][20], LAB was shown to be able to effectively preserve gut barrier integrity and prevent endotoxemia through cellular immunity, to stimulate production of suppressive cytokines (TGF-b, IL-10), to suppress CD4 ? T-cells and Th2 activity, and to decrease specific IgE and IgG 1 .…”

Section: Discussionmentioning

confidence: 98%

Lactic acid bacteria prevent alcohol-induced steatohepatitis in rats by acting on the pathways of alcohol metabolism

Liu

Wang

2008

Clin Exp Med

View full text Add to dashboard Cite

The objective is to study the possible mechanism by which lactic acid bacteria (LAB) prevent alcohol-induced steatohepatitis in rats. A total of 25 Wistar rats were divided into three groups: a LAB-fed group, an alcohol-treated group and a control group. Both the LAB-fed group and the alcohol-treated group received alcohol (10 g kg(-1) per day) orally for up to 5 days (125 h). Before exposure to alcohol, the LAB-fed group were first treated daily with 1.5 ml/100 g of a mixture comprising 4 x 10(10) ml(-1) of Lactobacillus acidophilus and 2.5 x 10(7) ml(-1) of Bifidobacterium longum, while the control group was treated with normal saline only. Biochemical data, alcohol dehydrogenase (ADH) activity and histology of the liver and stomach were evaluated. The ADH activity in the LAB mixture was 3.52 +/- 0.45 mumol mg(-1) protein (10(9) CFU ml(-1)), and was dose-dependent. By 30 min after taking alcohol, serum alcohol concentrations were 514.24 +/- 80.21 microg ml(-1) in the LAB-fed group and 795.15 +/- 203.45 microg ml(-1) in the alcohol-treated group (P < 0.005). Serum alcohol concentrations were reduced by 48% (P < 0.01) in the LAB-fed group, but by only 4% in the alcohol-treated group (P > 0.05) 120 min after oral intake of alcohol. The blood levels of endotoxin, AST and ALT were improved in the LAB-fed group compared to the alcohol-fed group (P < 0.01). All alcohol-treated rats showed moderate to severe steatohepatitis, but the LAB-fed rats showed almost normal histology or very slight lesions only. In conclusion, LAB decreased the alcohol concentration in the blood by increasing the first-pass metabolism in both the stomach and the liver, and effectively protected against alcohol-induced gastric and liver injury. It is interesting to note that the protection was more effective in the liver.

show abstract

“…(74) Further studies in animal models and humans, using Lc. mesenteroides strains alone should be done in order to confirm and understand the behavior of this microorganism in the host GIT.…”

Section: Metabolic Activitymentioning

confidence: 99%

“…(73) Further, a reduction of acute induced-peritonitis lung injury in rats was shown with preoperative enteral administration of symbiotic composition (10 9 CFU/g of each A c c e p t e d M a n u s c r i p t 16 edema (wet-to-dry lung weight ratio) was significantly reduced in the symbiotic-treated group (4.92 ± 0.13 vs. 5.07 ± 0.08 and 5.39 ± 0.10, respectively). (74) Further studies in animal models and humans, using Lc. mesenteroides strains alone should be done in order to confirm and understand the behavior of this microorganism in the host GIT.…”

Section: Metabolic Activitymentioning

confidence: 99%

The Two Faces ofLeuconostoc mesenteroidesin Food Systems

Paula

Jeronymo-Ceneviva

Todorov³

et al. 2014

Food Reviews International

View full text Add to dashboard Cite

Leuconostoc mesenteroides is a lactic acid bacterium (LAB) that has been isolated from differentsources. Some of its strains are able to produce bacteriocins, and most of them belong to class IIa and shows anti-Listeria activity. Additionally, Lc. mesenteroides specie can be a probiotic candidate; promising studies have shown the potential of this specie to survive and grow under various stress conditions present in the gastrointestinal tract (GIT). On the other hand, this microorganism can cause spoilage in some types of food matrices and scarce reports have shown the pathogenic potential of this specie. In this review, we focus on an overview of Lc. mesenteroides bacteriocins-producing strains and its probiotic potential, in contrast with Lc. mesenteroides the spoilage and pathogenic cases reported in the literature. IntroductionLeuconostoc genus belongs to Firmicutes phylum, which includes Gram positive, heterofermentative (fermenting glucose to D-lactic acid, ethanol/acetic acid, and CO 2 from phosphoketolase pathway) microorganisms, and presents coccoid or rod-like shape. These bacteria are usually presented in pairs or short chains, nonmotile, nonspore forming, catalase negative, anaerobic facultative, mesophilic and do not produce ammonia from arginine. They display complex nutritional requirements, including different amino acids. Furthermore, they exhibit absence of H 2 S formation, growth in presence of 7% NaCl and low guanine-cytosine (GC) content on the DNA molecule (31-49%). These microorganisms have mesophilic characteristics with optimal growth between 20 and 30 °C . Species belonging to genus Leuconostoc (Lc. argentinum, Lc. carnosum, Lc. citreum, Lc. fallax, Lc. ficulneum, Lc. fructosum, Lc. gasicomitatum,Lc. gelidum, Lc. inhae, Lc. kimchii, Lc. lactis, Lc.mesenteroides, Lc.pseudomesenteroides) can be found mainly in vegetables, cereals, silage, fruits, wine, fish, meat and dairy products. (1-9) A significant review published by Hemme and FoucaudScheunemann (3) presents an overview about Leuconostoc species, their habitat, taxonomy, metabolism and genetics, their implications in health and safety, and their potential use in dairy technology and functional foods.Despite the recent studies that show many benefits attributed to LAB, only a few reports about probiotic potential and bacteriocin applications using Lc. mesenteroides species have been found in the literature. Moreover, Leuconostoc spp. has a promising future for application in dairy foods as bacteriocinogenic and/or probiotic microorganism through enhancement of Downloaded by [University of Otago] at 04:40 14 March 2015A c c e p t e d M a n u s c r i p t 3 physicochemical characteristics of these products, mainly due to the production of organic acids, CO 2 and volatile compounds, which contribute to the flavor and texture of butter, cream and cheeses. In this paper, we review the potential of Lc. mesenteroides for application as a probiotic and bacteriocin-producing culture, in contrast with its relationship to spoilage process an...

show abstract

Pretreatment With Pro- and Synbiotics Reduces Peritonitis-Induced Acute Lung Injury in Rats

Abstract: Three weeks of preoperative enteral administration of a synbiotic composition reduced peritonitis-induced acute lung injury in rats in a CLP model.

Cited by 25 publications

References 38 publications

Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

Lactic acid bacteria prevent alcohol-induced steatohepatitis in rats by acting on the pathways of alcohol metabolism

The Two Faces ofLeuconostoc mesenteroidesin Food Systems

Contact Info

Product

Resources

About