2021
DOI: 10.12659/msm.930478
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Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway

Abstract: Background Propofol improves rodent pulmonary injury after intestinal ischemia-reperfusion (IIR). However, its effect and underlying mechanisms in large animals remain unclear. Here, we examined whether pretreatment with propofol could relieve lung injury during IIR in pigs, then investigated the underlying mechanism. Material/Methods A porcine model of IIR-induced lung injury was built by clamping the super mesenteric artery for 2 h and loosening the clamp for 4 h. Ran… Show more

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Cited by 3 publications
(4 citation statements)
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“…Moreover, the interplay between HMGB1-TLR4-MyD88 and ischemia-reperfusion signaling pathways has been studied [ 53 , 54 ]. Propofol pretreatment alleviated IRI-induced lung injury in pigs by inhibiting the HMGB1-TLR4-PKR signaling pathway [ 55 ]. Given the interactions among HMGB1, TLR4, and MyD88 identified in previous research, this study analyzed the effects of butyrate intervention on their proteins.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the interplay between HMGB1-TLR4-MyD88 and ischemia-reperfusion signaling pathways has been studied [ 53 , 54 ]. Propofol pretreatment alleviated IRI-induced lung injury in pigs by inhibiting the HMGB1-TLR4-PKR signaling pathway [ 55 ]. Given the interactions among HMGB1, TLR4, and MyD88 identified in previous research, this study analyzed the effects of butyrate intervention on their proteins.…”
Section: Discussionmentioning
confidence: 99%
“…Some studies proved mucosal mast cell (IMMC) activation is critical in intestinal IRI by secreting many mediators to induce intestinal epithelial injury and integrity disruption. Propofol preconditioning can suppress IMMC activation, and it can explain why propofol can attenuate Intestinal IRI, restore intestinal epithelial cell integrity, and prevent intestinal IRI-induced lung injury in rodents and even pigs from other perspectives ( Zhao et al, 2014 ; Gan et al, 2015 ; Bian et al, 2021 ; Li et al, 2022a ). The above findings showed propofol may provide a meaningful anesthetic management regimen for preventing intestinal IRI and organ injury following major surgery and is worthy of a further clinical study to examine the clinical significance.…”
Section: Propofolmentioning
confidence: 99%
“…Researchers have employed various animal species to establish II/R models in order to fulfil the requirements for detecting corresponding indicators. For example, Li et al ( 9 ) utilized C57BL/6J mice, Chen et al ( 10 ) employed Sprague-Dawley rats, Bian et al ( 11 ) utilized pigs, and Anderson et al ( 12 ) utilized horses. Moreover, the timing of sample collection for intestinal tissue ischemia and reperfusion varies.…”
Section: Animal Models and Indicators For Lung Injury Assessmentmentioning
confidence: 99%
“…Blocking HMGB1 reverses these effects, protecting lung tissue from inflammation ( 6 ). In a porcine II/R model, propofol pretreatment decreased inflammatory factor and oxidative stress-related substance levels in lung tissue, improved II/R-induced hypoxemia and acidemia, reduced airway resistance, and protected lung function by inhibiting the expression of the HMGB1/TLR4/PKR signaling pathway ( 11 ). In the oxygen and glucose deprivation/reoxygenation (OGD/R) model of mouse lung epithelial cells, silencing Nrf2 increased OGD/R-induced upregulation of TLR4 and MyD88, and exacerbated apoptosis and autophagy, revealing the role of the Nrf2/TLR4/MyD88 axis in inflammation-related lung injury ( 25 ).…”
Section: The Mechanism Of Intestinal Ischemia/reperfusion-induced Acu...mentioning
confidence: 99%