Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital

Kanamori, Hajime; Tokuda, Koichi; Ikeda, Shinobu; Endo, Shiro; Ishizawa, Chiyuki; Hirai, Yukari; Takahashi, Masami; Aoyagi, Tetsuji; Hatta, Mochammad; Gu, Yoshiaki; Yano, Hisakazu; Weber, David J.; Kaku, Mitsuo

doi:10.1620/tjem.234.111

Cited by 10 publications

(6 citation statements)

References 9 publications

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“…Compared with the international literature, we found similar rates of seropositivity for measles, mumps, VZV and HBV. However, the rates of seropositivity for rubella were considerably lower in our studied population of HCWs (78%) than have been reported with other recent Australian 11,13 and international 7–10 studies (seropositivity rates range from 83% to 91%). Vagholkar and colleagues found 91% of HCWs were seropositive to measles, 89% for mumps, 91% for rubella, 89% to VZV and only 64% for HBV 11 .…”

Section: Discussioncontrasting

confidence: 79%

“…Previous studies both internationally and in Australia over the past decade have described the seroepidemiology of some or all of these VPDs among HCWs. Overall, the average seroprotection to measles has been shown to be 92% (range 54–100%); 88% for mumps (69–97%); 91% for rubella (83–98%); 92% for VZV (71–99%); and 80% for HBV (58–96%) 7–14 . However, the results of these studies are not necessarily generalisable to other contexts and only a minority included analysis of other potential predictive factors of immunity such as self‐reported disease and vaccination history or demographic factors such as year of birth and country of origin.…”

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confidence: 99%

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Seroprotection to vaccine‐preventable diseases among workers at a Victorian tertiary hospital

Andrew¹,

Gibney²,

Denholm³

et al. 2016

Australian and New Zealand Journal of Public Health

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Objective: To determine seroprotection for the vaccine‐preventable diseases (VPDs) measles, mumps, rubella, varicella and hepatitis B among new employees seen at a Victorian tertiary hospital staff clinic. Methods: Employees who presented to the staff clinic for immunisation assessment between 1 January 2012 and 31 December 2013 were included. Demographic data, self‐reported disease history and previous vaccination status were reviewed retrospectively to determine impact on serological results. Results: A total of 1,901 new employees were included, 83% of whom were at risk of direct contact with blood or body substances. Overall, the proportion of workers seropositive to measles was 88%, mumps 90%, rubella 78%, varicella 93% and hepatitis B 80%. Staff born before 1966 were more likely to have positive measles or mumps serology but negative rubella or hepatitis B serology (p<0.05 for each). Staff who self‐reported measles (99% vs. 93%, p=0.03) or varicella infection (98% vs. 92%, p<0.001) were more likely to be seropositive, but those reporting previous vaccination to measles, mumps or rubella were no more likely to be seropositive. Conclusions and implications: This study demonstrated levels of seropositivity of 78–93% for the five VPDs. Despite recognised limitations of serological testing, 10–20% of new employees to a healthcare institution lacking seroprotection represents a potentially unacceptable risk of nosocomial transmission of these VPDs. Our findings support ongoing serological testing of new healthcare staff at risk of direct contact with blood or body substances.

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Section: Discussioncontrasting

confidence: 79%

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confidence: 99%

Seroprotection to vaccine‐preventable diseases among workers at a Victorian tertiary hospital

Andrew¹,

Gibney²,

Denholm³

et al. 2016

Australian and New Zealand Journal of Public Health

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“…Our consolidated hospital-wide seroprevalence of 92.8 % (95 % CI 92.1–93.5) in 2014 was comparable. Still, we were not able to achieve the rates reported in Japanese healthcare institutions which can range between 94.7 and 97.4 % [ 10 – 12 ]. Data on HCWs in the wider Southeast Asian region are not available for comparison, save for a small sample studied in Malaysia, which showed a seroprevalence of 84.4 % [ 13 ].…”

Section: Discussionmentioning

confidence: 78%

Varicella seroprevalence in healthcare workers in a tertiary hospital: an audit of cross-sectional data

et al. 2015

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BackgroundThe seroprevalence of varicella in Southeast Asia is not well described especially in healthcare workers (HCW) in the region. We report the varicella seroprevalence among healthcare workers from a diverse range of countries working in a tertiary care hospital in Singapore.MethodsWe audited the results of annual HCW health screening, which included a varicella assay, from the years 2009 to 2014. During this period, there was a change in hospital policy mandating varicella immunity for all newly employed healthcare workers. The serological data were reviewed with employment records on occupation and nationality. Seroprevalence rates were determined by standard commercial enzyme linked immunosorbent assays for each year of testing. Odds of being immune in 2014 were compared by means of multiple logistic regression.ResultsA total of 10,585 samples were obtained from 6668 unique individuals over four separate cross-sections of the hospital workforce. A peak seroprevalence of 92.8 % (95 % CI 92.0–93.5) was recorded in 2014. Younger employees had a lower seroprevalence than their older colleagues. In a consolidated sample of 4875 members of the active workforce in October 2014, we identified that Indian nationals were less likely to be immune than their Singaporean national colleagues, odds ratio (OR) 0.26 (95 % CI 0.17–0.43, p < 0.001), while Chinese nationals were more likely to be immune, OR 4.34 (95 % CI 1.61–12.2, p = 0.004), after controlling for year of screening, gender, age-group and vocation. In 2014, being employed as administrative staff, OR 0.43 (95 % CI 0.29–0.64, p < 0.001) or contract service provider, OR 0.30 (95 % CI 0.19–0.47, p < 0.001), was also associated with a lower odds of being immune than being employed as a nurse.ConclusionsThere remain a small number of healthcare workers who are non-immune to varicella in our tertiary hospital. A new pre-employment policy of mandatory screening and vaccination may have increased rates of immunity but more needs to be done to ensure that all of our employees are immune to varicella to protect our vulnerable patients.

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“…In Japan, there are two opportunities to receive measles and rubella vaccinations for individuals born after 1990 according to Japan's vaccination policy [17]. All students analyzed in the present study were born after 1990 except for five in the measles analysis and three in the rubella analysis.…”

Section: Discussionmentioning

confidence: 94%

Relationship between Self-Reported Vaccination History and Measles and Rubella Antibody Titers in Medical and Nursing Students

Ogawa¹,

Ae²,

Sasahara³

2017

AID

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In hospitals, infection control for measles and rubella is important. Medical and nursing students as well as healthcare workers must have immunity against these diseases. Many countries have adopted requirements for healthcare workers' documented vaccination history or laboratory tests as evidence of their immunity. Evaluating a written vaccination history is difficult in many cases. Therefore, we compared measles and rubella antibody titers with self-reported vaccination history and we evaluated the association between the history and measles and rubella antibody titers, using the medical and nursing students' data. We analyzed 564 data for measles and 558 data for rubella. Vaccination history was requested to be completed as accurately as possible. Students with one or more measles or rubella vaccinations had high positive ratios of titer, and the ratio was significantly higher than that of the students without vaccinations. The positive ratio between the two-dose and one-dose vaccination groups was not significantly different for measles or rubella (measles: p = 0.534, rubella: p = 0.452). Although it should be requested that the history is complete by using other resources, such as referring to maternity passbooks or proof of vaccination, self-reported history may be useful to confirm immunity, even if there is a possibility that the history is not accurate.

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Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital

Cited by 10 publications

References 9 publications

Seroprotection to vaccine‐preventable diseases among workers at a Victorian tertiary hospital

Seroprotection to vaccine‐preventable diseases among workers at a Victorian tertiary hospital

Varicella seroprevalence in healthcare workers in a tertiary hospital: an audit of cross-sectional data

Relationship between Self-Reported Vaccination History and Measles and Rubella Antibody Titers in Medical and Nursing Students

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