Prevailing Effects of Ibutilide on Fast Delayed Rectifier K+ Channel

Kodirov, Sodikdjon A.; Zhuravlev, V. L.; Brachmann, Johannes

doi:10.1007/s00232-019-00098-x

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…The electrophysiological mechanisms of cardioversion are mainly as follows: By inhibiting potassium channels, it speci cally inhibits potassium currents, but the difference is that ibutilide also promotes sodium and calcium in ux in the plateau phase and plays a role in prolonging the plateau phase of action potential in cardiomyocytes; it causes prolongation of action potential duration and prolongation of QTc in cardiomyocytes, and then exerts its antiarrhythmic effect [10][11] . Ibutilide is more effective in inhibiting atrial myocardium than sinus node, atrioventricular node and ventricular myocardium, so it is more effective in inhibiting atrial arrhythmia than ventricular arrhythmia [12] . At present, many domestic and foreign scholars have studied the rational use of ibutilide in atrial brillation ablation.…”

Section: Of Postoperative Maintenance Time Of Normal Sinus Rhythm In ...mentioning

confidence: 99%

Analysis of the success rate of conversion using ibutilide administration in radiofrequency catheter ablation of persistent atrial fibrillation and its effects on postoperative recurrence

Liu

Zhou³

et al. 2023

Preprint

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OBJECTIVE To assess the efficacy of ibutilide administration during radiofrequency catheter ablation of persistent atrial fibrillation (AF), to explore the success rate of conversion and related influential factors, and to analyze the effects of ibutilide on postoperative recurrence. METHODS A total of 192 patients with persistent AF who underwent catheter ablation from January 1, 2019, to December 31, 2021. These patients failed in conversion of AF to normal sinus rhythm by intraoperative catheter ablation. Patients were assigned into effective ibutilide (115 patients) and ineffective ibutilide (77 patients) groups. RESULTS The overall success rate of conversion using ibutilide administration was 59.9%. The success rate was associated with the duration of AF (P = 0.008), diameter of left atrium (LAD) (P = 0.002), and N-terminal pro-brain natriuretic peptide (NT-proBNP) level (P = 0.030). The results showed the duration of AF was associated with early recurrence, while early recurrence was not a risk factor for late recurrence. And duration of AF was associated with postoperative maintenance time of normal sinus rhythm, whereas successful conversion into normal sinus rhythm using ibutilide administration had no influence on postoperative maintenance time of normal sinus rhythm. CONCLUSION Ibutilide showed to be effective in catheter ablation of AF, the success rate of conversion was correlated with the duration of AF, LA diameter, and NT-proBNP level. Besides, the duration of AF was found as a risk factor for early postoperative recurrence, while ibutilide administration for successful conversion had no influence on predicting postoperative recurrence and had no influence on postoperative maintenance time of sinus rhythm.

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Section: Of Postoperative Maintenance Time Of Normal Sinus Rhythm In ...mentioning

confidence: 99%

Analysis of the success rate of conversion using ibutilide administration in radiofrequency catheter ablation of persistent atrial fibrillation and its effects on postoperative recurrence

Liu

Zhou³

et al. 2023

Preprint

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“…For instance, amiodarone (anti-arrhythmic drug, VGPC channel blocker) can also block L-type calcium, potassium and sodium currents; prolong phase 3 of the cardiac action potential; and reduce pulse rate in humans [174][175][176]. It was also shown that ibutilide (anti-arrhythmic drug, VGPC blocker) inhibited the activity of hERG potassium channels and delayed inward rectifier potassium and L-type calcium channels in Guinea pig cardiomyocytes [177]. The other antiarrhythmic drugs flecainide and quinidine work mainly by blocking the Nav1.5 sodium channel [178,179].…”

Section: Complex Activity Of Ion Channel Regulatorsmentioning

confidence: 99%

Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels

Vaiciuleviciute

Bironaitė

Uzielienè

et al. 2021

Cells

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Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features, including similar risk factors and molecular mechanisms. A great number of cardiovascular drugs act via different ion channels and change ion balance, thus modulating cell metabolism, osmotic responses, turnover of cartilage extracellular matrix and inflammation. These drugs are consumed by patients with CVD for many years; however, information about their effects on the joint tissues has not been fully clarified. Nevertheless, it is becoming increasingly likely that different cardiovascular drugs may have an impact on articular tissues in OA. Here, we discuss the potential effects of direct and indirect ion channel modulating drugs, including inhibitors of voltage gated calcium and sodium channels, hyperpolarization-activated cyclic nucleotide-gated channels, β-adrenoreceptor inhibitors and angiotensin-aldosterone system affecting drugs. The aim of this review was to summarize the information about activities of cardiovascular drugs on cartilage and subchondral bone and to discuss their possible consequences on the progression of OA, focusing on the modulation of ion channels in chondrocytes and other joint cells, pain control and regulation of inflammation. The implication of cardiovascular drug consumption in aetiopathogenesis of OA should be considered when prescribing ion channel modulators, particularly in long-term therapy protocols.

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Cardiac hERG K+ Channel as Safety and Pharmacological Target

Sun

Wang

et al. 2021

Handbook of Experimental Pharmacology

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Prevailing Effects of Ibutilide on Fast Delayed Rectifier K+ Channel

Cited by 6 publications

References 45 publications

Analysis of the success rate of conversion using ibutilide administration in radiofrequency catheter ablation of persistent atrial fibrillation and its effects on postoperative recurrence

Analysis of the success rate of conversion using ibutilide administration in radiofrequency catheter ablation of persistent atrial fibrillation and its effects on postoperative recurrence

Cardiovascular Drugs and Osteoarthritis: Effects of Targeting Ion Channels

Cardiac hERG K+ Channel as Safety and Pharmacological Target

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