Prevalence and 20-year epidemiological trends of glomerular diseases in the adult Saudi population: a multicenter study

Alfaadhel, Talal; Alsuwaida, Abdulkareem; Alsaad, Khaled O.; Ahmed, Noura; AlHamad, Mahmoud Yassin; Bakheet, Ammar; Wadera, Junaid J.; Mokhtar, Ghadeer; Alsuwaida, Feras A.; Siddiqui, Rabia; Kechrid, M; Abdelrehman, Ashraf; Husain, Sufia; Kfoury, Hala; Alabdulsalam, Abdulrahaman; Alanazi, Majed; Oudah, Noura Al; Alhozali, Hanadi

doi:10.5144/0256-4947.2019.155

Cited by 10 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In South America, a Brazilian study found focal segmental glomerulosclerosis to be the most frequent aetiology (28.8%) and only 18.3% were IgA nephropathy [24]. Finally, epidemiological studies in the Middle East reported that focal segmental glomerulosclerosis was the most commonly diagnosed glomerulonephritis (35% of cases) in Iraq, whereas IgA nephropathy accounted for only 7% of cases [25] and in Saudi Arabia focal segmental glomerulosclerosis accounted for 39.8% of cases [26].…”

Section: Discussionmentioning

confidence: 98%

Incidence of glomerulonephritis in the western part of Switzerland over the last decade

et al. 2020

View full text Add to dashboard Cite

BACKGROUND: Glomerulonephritis is a rare yet serious group of diseases with a high risk of progression to endstage renal disease. For optimal healthcare planning, detailed epidemiological and demographic data are essential. Despite their clinical relevance, these data are largely lacking in Switzerland.OBJECTIVE: The objective of this study was to assess the incidence of the different forms of glomerulonephritis in the western part of Switzerland and its changes over the last 10 years, compared with international data.METHODS: We listed all renal biopsy reports analysed between 2007 and 2016 at the University hospital of Lausanne, the renal pathology reference centre of all hospitals in the cantons of Vaud, Fribourg, Valais and Neuchâtel. Biopsies with a first diagnosis of primary glomerulonephritis were included in the analysis. The incidence was calculated as the number of patients newly diagnosed with glomerulonephritis divided by the number of inhabitants of all the above-mentioned cantons during the year under review, as retrieved from the federal statistical office of Switzerland.RESULTS: We collected biopsy reports from 864 patients between 2007 and 2016; 168 biopsies met the inclusion criteria. The most common primary glomerulonephritis was IgA nephropathy at 32.7% of cases, followed by lupus nephritis (29.8%) and pauci-immune glomerulonephritis (11.9%). Overall, the mean incidence of glomerulonephritis was 1.3/100,000/year. Between 2007 and 2016, the incidence of all glomerulonephritis taken together remained stable. The same was true for the incidence of IgA nephropathy, lupus nephritis and pauci-immune glomerulonephritis. In contrast, we observed a trend towards higher creatinine levels, proteinuria and degree of interstitial fibrosis at diagnosis. CONCLUSION:The incidence of glomerulonephritis in the western part of Switzerland was low and remained stable over time, in line with European data.

show abstract

Section: Discussionmentioning

confidence: 98%

Incidence of glomerulonephritis in the western part of Switzerland over the last decade

et al. 2020

View full text Add to dashboard Cite

show abstract

“…14 In contrast to a previous 20-year-long study, we found a higher prevalence of FSGS in the pediatric population in our study. 15 The multicenter study from Saudi Arabia reported that among the several glomerulonephrites, FSGS was most frequent, with an average prevalence of 21.2 in the last 20 years. 15 In a similar study by Mubarak et al mean age of 9.79±4.59 years was reported, which WAS greater than the current study.…”

Section: Discussionmentioning

confidence: 99%

“…15 The multicenter study from Saudi Arabia reported that among the several glomerulonephrites, FSGS was most frequent, with an average prevalence of 21.2 in the last 20 years. 15 In a similar study by Mubarak et al mean age of 9.79±4.59 years was reported, which WAS greater than the current study. A much higher occurrence of minimal change disease, i.e., 43.8, was observed compared to the 12.32 occurrence in our study.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Analysis of Biopsy-Proven Glomerulonephritis in the Pediatric Patients : A Study from Tertiary Care Centre

Safdar

Khan²,

Mehar³

et al. 2022

PAFMJ

View full text Add to dashboard Cite

Objective: To evaluate the clinic-pathological characteristics and their association with biopsy-proven glomerulonephritis in pediatric patients. Study Design: Prospective longitudinal study. Place and Duration of Study: Pediatric Department Nishtar Medical University, Multan Pakistan, from Jan 2014 to Dec 2019. Methodology: During the study, a total of 211 renal biopsy reports of different age groups were studied and analyzed for clinic-pathological features and patterns of direct immunofluorescence. Results: The mean age of 8.6±3.25 years was observed. The most common pathology was focal segmental glomerulo-sclerosis in 86 (40.76) of the patients, followed by mesangio-proliferative glomerulonephritis in 41 (19.43) of the patients. Minimal change disease was seen in 26 (12.32) cases. It was observed that the majority of the patients with diffuse proliferative glomerulonephritis were younger than 11 years old, whereas; 10 (11.2), patients with lupus nephritis, 11 (15.1) and membranous nephropathy, 10 (12.2) were comparatively older. Conclusion: Glomerulonephritis presents a diversified group of diseases with overlapping clinic-pathological features. The present study has reported many significant characteristics which could help diagnose a particular disorder among the pediatric population.

show abstract

“…Among the sequale of diabetes mellitus that occur after long time is the progressive development of the some complications like retinopathy with possibility of development of blindness, nephropathy with possibility of development of renal failure, and/or neuropathy (4). A recent study conducted by AlFaadhel et al in Saudi Arabia (5). They found that the most common secondary types of glomerular diseases was the systemic lupus erythematosus-associated lupus nephritis followed by diabetic nephropathy.…”

Section: Introductionmentioning

confidence: 97%

Renoprotective Effect of Ocimum Basilicum (Basil) Against Diabetes-induced Renal Affection in Albino Rats

Almalki

2019

Mater Sociomed

View full text Add to dashboard Cite

Introduction: Diabetic nephropathy is the second most common secondary type of glomerular diseases among Saudi patients after systemic lupus erythematosus. Ocimum basilicum (O. basilicum) was reported to have anti-diabetic and antioxidants effects. Aim: This study aimed to evaluate the efficacy of O. basilicum in controlling STZ-induced diabetes mellitus in rats and preserving the structure of kidney against diabetes-induced nephropathy. Methods: This study utilized forty adult male Spraque-Dawley rats assigned into four groups (n=10 each); control, streptozotocin-induced diabetic, metformin-treated and O. Basilicum-treated groups. The blood glucose level (BGL), total antioxidant capacity (TAC), serum creatinine and BUN levels were assessed. Kidneys were dissected out and processed for histopathological and immunohistochemical assessment. Results: The BGL significantly decreased in Metformin-and O. basilicumtreated (p=0.02, p=0.01) rats while TAC significantly increased (p=0.01, p=0.003) respectively, compared to the untreated diabetic rats. In addition, O. basilicum significantly reduced (p=0.004, p=0.02) both creatinine and BUN levels compared to the untreated diabetic group, respectively. Examination of kidney of O. basilicum-treated diabetic rats revealed few degenerated renal tubules, with no inflammatory cell infiltrates, peritubular capillaries congestion and minimal peritubular collagen fibers deposition. It also reduced immunoexpression of desmin and αsmooth muscle actin in glomeruli of O. basilicum-treated diabetic rats. Conclusion: Glucose lowering and antioxidant effects of O. basilicum was evident biochemically in this study. O. basilicum could protect the kidney against diabetesinduced nephropathy as revealed biochemically and histopathologically. Further exploration of the mechanism and assessment of efficacy in human through clinical study are recommended.

show abstract

Prevalence and 20-year epidemiological trends of glomerular diseases in the adult Saudi population: a multicenter study

Cited by 10 publications

References 22 publications

Incidence of glomerulonephritis in the western part of Switzerland over the last decade

Incidence of glomerulonephritis in the western part of Switzerland over the last decade

Clinicopathological Analysis of Biopsy-Proven Glomerulonephritis in the Pediatric Patients : A Study from Tertiary Care Centre

Renoprotective Effect of Ocimum Basilicum (Basil) Against Diabetes-induced Renal Affection in Albino Rats

Contact Info

Product

Resources

About