Prevalence and Antibiotic Resistance Pattern of Methicillin-ResistantStaphylococcus aureusfrom an Orthopaedic Hospital in Nigeria

Abstract

Patients with surgical wounds have been reported to be at high risk of MRSA carriage and infection. The prevalence and antibiotic resistance pattern of this organism in the orthopaedic ward of Ahmadu Bello University Teaching Hospital (ABUTH), Zaria-Nigeria, a 547-bed Nigerian hospital, were thus studied. A total of 185 isolates of Staphylococcus aureus were confirmed from 217 samples taken from the orthopaedic wards of the hospital using standard isolation methods. Out of these, 44 (23.8%) were from the wounds of patients and 70 (37.8%) from the skin. The remaining 65 (35.1%) and 6 (3.2%) were from their beds and the atmospheric air, respectively. Out of these, 33 (75%), 36 (51.4%), and 48 (73.8%) from wounds, skin, and bed, respectively, were found to be methicillin-resistant Staphylococcus aureus (MRSA) using the disc-sensitive test methods. None was detected from the atmosphere. The antibiotic susceptibility pattern results showed the level of resistance to be ampicillin 100% in all the three sites, pefloxacin 90.9%, 72.2%, 66.7%, ceftriaxone 69.7%, 72.2%, 70.8%, gentamicin 54.5%, 52.8%, 37.5%, and ciprofloxacin 51.5%, 47.2%, 35.4% at the wound, skin, and bed sites, respectively. Results confirm that MRSA continues to pose a threat to the hospitalized patients, especially those with bone and wound infections.

Antibiotic Susceptibility Pattern of Methicillin Sensitive and Resistant Staphylococcus aureus from Clinical Isolates in a Tertiary Care Hospital at Mathura, Western Uttar Pradesh

“…Data on the prevalence of MRSA is not uniform. Literature has documented a significant variation in the prevalence rate from different parts of India and between countries [1][2][3][4][5][6][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Studies from India report MRSA prevalence ranging from 6.9% to 87% 9 .…”

Prevalence and Antibiotic Susceptibility Patterns of Methicillin Resistant Staphylococcus Aureus in Patients Attending the Laquintinie Hospital Douala, Cameroon

“…MRSA strains exhibit resistance to oxacillin or methicillin and other antimicrobial agents and this has been used in the diagnosis of these strains [4,5]. The emergence of resistance in these strains of S. aureus is mediated by a change in penicillin binding protein (PBP2a) which is encoded by the Mec A gene, resulting to strains with multiple resistance to various antibiotics [1,6].…”

Frequency of methicillin-resistant Staphylococcus aureus (MRSA) in nose and cellular phone of medical and non-medical personnel of emergency departments of Ghaem hospital in Mashhad city

“…21 Investigation of Prevalence and antibiotic resistance pattern of methicillin-resistant Staphylococcus aureus in the Orthopaedic Hospital in Nigeria by Udobi et al showed resistance pattern of: ampicillin 100%, pefloxacin 90.9%, ceftriaxone 69.7%, gentamicin 54.5%, and ciprofloxacin 51.5%. 30 The study by Anupriya et al revealed that microbial contamination of mobile phones in a tertiary care hospital was 87.3% and 56.4% among health care workers versus non-health care workers, but there was no MRSA. 31 A Study by Nirmal et al among health-care workers, explained that HA-MRSA carriage was seen in 47 individuals in their nasal vestibules; the colonization rate was 15.1%.…”