Prevalence and Antibiotic Resistance Profiles of Carbapenem-Resistant Klebsiella Pneumoniae Isolated from Tertiary Care Hospital, Egypt

Abstract

Background: Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) dissemination is a major healthcare problem due to its limited treatment options.Objective: This study aimed to determine the prevalence and antimicrobial resistance profile of hospital infections caused by CR-Kp in Al-Ahrar Teaching Hospital. The study was conducted through the period from January 1, 2021 to December 31, 2021. Patients and Methods: 650 clinical samples were collected from different ICU departments. Klebsiella pneumoniae isolates were identified by conventional methods. Susceptibility to carbapenems and other antibiotics was determined by disk diffusion method. Results: Out of 650 clinical specimens, 142 K. pneumoniae were isolated with an isolation rate of 21.8%. K. pneumoniae showed that the majority (60.6%) of isolates were extensively-drug resistant (XDR), while 30.3% were multidrug resistant (MDR) and only 9.2% were susceptible. By disk diffusion method, the incidence of CR-Kp was 25.4% (36/142). Antibiotic susceptibility test showed that 100% of CR-Kp isolates were resistant to Amoxicillin/Clavulanic acid, Ampicillin/Sulbactam, Pipracillin/Tazobactam, cefepime, ceftriaxone, cefotaxime, cefoxitin, ceftazidime and nitrofurantoin. High rate of resistance was also evident to aztreonam, norfloxacin (88.9%, for each) and amikacin (61.1%). Levofloxacin owned the lowest resistance rate (30.6%), followed by ciprofloxacin (44.4%) and gentamycin (47.2%). Antibiotic resistance pattern of isolated CR-Kp showed that the majority of the isolates (97.2%) were XDR, while only 2.8% were MDR. Conclusion: About quarter of K. pneumoniae isolates were carbapenem-resistant with predominance of XDR isolates which represents a warning sign for which application of antibiotic stewardship is mandatory as well as strict infection control policies for prevention of development of pan-drug resistant bacteria.

Ceftazidime-Avibactam plus aztreonam synergistic combination tested against carbapenem-resistant Enterobacterales characterized phenotypically and genotypically: a glimmer of hope

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Prevalence of Antibiotic Resistance in Pediatric Malignancy Patients: A Two-Year Retrospective Study in Basra City

“…(9) , Febrile neutropenia only 29 (5.8%) because our retrospective study and the data of patients taken from the hospital information department and laboratory department, not all data were written in the patient's medical reports. In contrast with a study conducted (10) where 172 episodes of FN in 77 patients were evaluated 54.7% of the FN episodes were in male patients and 45.3% of the FN were female.…”

Genotyping and molecular investigation of plasmid-mediated carbapenem resistant clinical <i>Klebsiella pneumoniae</i> isolates in Egypt

“…These carbapenemases are plasmid-mediated and can be easily disseminated in the community as well as in hospital wards conferring a great impact on public health [13] . In Egypt, many studies showed a high level of carbapenem resistance among hospital K. pneumoniae isolates [14] , [15] .…”